Deep vein thrombosis is a debilitating condition that can require rapid intervention to prevent amputation of the affected limb or death. The current interventional approaches are not effective for older, chronic thrombi, characteristic of those found in deep vein thrombosis. Histotripsy is a novel form of therapeutic ultrasound that employs the mechanical action of oscillating cavitation bubbles to ablate thrombi. Preliminary data from Dr. Bader demonstrate that the thrombolytic recombinant tissue plasminogen activator acts synergistically with histotripsy pulses to provide enhanced thrombolysis in highly retracted venous clots. Further studies will elucidate the efficacy and potential risks of histotripsy to ablate venous thrombosis, and provide new information to assist the development of targeted ablation methods to improve thrombolysis in the treatment of currently intractable deep vein thrombosis.