Publications

2022

Genomic and Transcriptional Mechanisms Governing Innate-like T Lymphocyte Development. Morgan RC, Kee BL. J Immunol. 2022 July 15;209(2):208-216.
E Protein Transcription factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia. Parriott G, Kee BL. Front Immunol. 2022 Apr 20;13:885144.
Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 in a Murine Model of T Acute Lymphoblastic Leukemia. Carr T, McGregor S, Dias S, Verykokakis M, LeBeau MM, Xue HH, Bartom ET, Kee BL. Front Immunol. 2022 Mar 18;13:845488.

2021

The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. Li ZY, Hegermiller E, Sun M, Bartom ET, Maienschein-Cline M, Sigvardson M, Kee BL. J Exp Med, 218(6):e2020032, 2021.

2020

It’s a Phase that EBF1 is going through. Kee BL. Immunity 53(6):1123-1125. (Preview of Wang & Grosschedl).
The transcription factor Bcl6 controls early development of innate-like T cells. Gioulbasani M, Galaras A, Grammenoudi S, Moulos P, Dent A, Sigvardsson M, Hatzis P, Kee BL*, Verykokakis M*. Nature Immunology, 21:1058-1069, 2020. *co-corresponding authors.
Combinatorial ETS1-dependent control of oncogenic NOTCH1 enhancers in T-cell leukemia. McCarter AC, Della Gatta G, Melnick A, Kim E, Sha C, Wang Q, Nalamolu JK, Liu Y, Keeley T, Yan R, Sun M, Kodgule R, Kunnath N, Ambesi-Impiombato A, Kuick R, Rao A, Ryan RJH, Kee BL, Samuelson LC, Ostraowski MC, Ferrando AA, Chiang MY. Blood Cancer Discovery, in press, published OnlineFirst July 14, 2020.
Transcriptional regulation of natural killer cell development and maturation. Kee BL, Morman RE, Sun M. Adv Immunol. 146:1-28, 2020.
Ezh2 Represses Transcription of Innate Lymphoid Genes in B lymphocyte progenitors and Maintains the B-2 Cell Fate. Jacobsen JA, Bartom ET, Sigvardsson M, Kee BL. J Immunol February 24, 2020.

2019

Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1. de Pooter RF, Dias S, Chowdhury M, Bartom ET, Okoreeh MK, Sigvardsson M, Kee BL. J Immunol. 2019 May 15;202(10):2837-2842.
Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. Nat Immunol. 2019 Sep;20(9):1161-1173.
Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf. Durai Pham D, Moseley CE, Gao M, Savic D, Winstead CJ, Sun M, Kee BL, Myers RM, Weaver CT, Hatton RD. Cell Rep. 2019 Oct 29:29(5):1203-1220.

2018

Transcription factor ID2 prevents E proteins from encoding a naïve T lymphocyte gene program during NK Cell Development Zook EC, Li ZY, Xu Y, de Pooter RF, Verykokakis M, Beaulieu A, Lasorella A, Maienschein-Cline M, Sun JC, Sigvardsson M, Kee BL. Sci Immunol. 2018 Apr 27;3(22). pii: eaao2139.
Transcriptional and epigenetic regulation of innate-like T lymphocyte development. Verykokakis M, Kee BL. Curr Opin Immunol. 2018 Apr;51:39-45.

2017

Lnc’ing Id2 to ILC1. Sun M, Kee BL. Immunity. 2017 Sep 19;47(3):389-390.
EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. J Immunol. 2017 Jun 15;198(12):4682-4691.
Applying the TOR(C)QUE in iNKT cells: A new twist in an old tale. Verykokakis M, Kee BL. Eur J Immunol. 2017 Mar;47(3):454-457.
Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. Gabrielli S, Sun M, Bell A, Zook EC, de Pooter RF, Zamai L, Kee BL. Eur J Immunol. 2017 May;47(5):800-805.

2016

Development of innate lymphoid cells. Zook EC, Kee BL. Nat Immunol. 2016 Jun 21;17(7):775-82.
The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2. Zook EC, Ramirez K, Guo X, van der Voort G, Sigvardsson M, Svensson EC, Fu YX, Kee BL. J Exp Med. 2016 May 2;213(5):687-96.
Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells. Block KE, Zheng Z, Dent AL, Kee BL, Huang H. J Immunol. 2016 Feb 15;196(4):1550-7.

2015

Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. Xu Y, Evaristo C, Alegre ML, Gurbuxani S, Kee BL. PLoS One. 2015 Apr 29;10(4):e0125211.
Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota. Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX. Immunity. 2015 Apr 21;42(4):731-43.
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector differentiation. Carr T, Krishnamoorthy V, Yu S, Xue HH, Kee BL, Verykokakis M. J Exp Med. 2015 May 4;212(5):793-807.
Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL. J Immunol. 2015 Apr 1;194(7):3191-200. doi: 10.4049/jimmunol.1402443. Epub 2015 Feb 20. Erratum in: J Immunol. 2015 Jun 15;194(12):6191.

2014

ID’ing innate and innate-like lymphoid cells. Verykokakis M, Zook EC, Kee BL. Immunol Rev. 2014 Sep;261(1):177-97.
Sox4 B-lymphocyte progenitors. Kee BL. Blood. 2014 Jun 26;123(26):4009-10.

2013

Essential functions for ID proteins at multiple checkpoints in invariant NKT cell development. Verykokakis M, Krishnamoorthy V, Iavarone A, Lasorella A, Sigvardsson M, Kee BL. J Immunol. 2013 Dec 15;191(12):5973-83.
Fingerprinting ikaros. Gounari F, Kee BL. Nat Immunol. 2013 Oct;14(10):1034-5.
E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment. Xu W, Carr T, Ramirez K, McGregor S, Sigvardsson M, Kee BL. Blood. 2013 Feb 28;121(9):1534-42.

2012

Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors. Pereira de Sousa A, Berthault C, Granato A, Dias S, Ramond C, Kee BL, Cumano A, Vieira P. J Immunol. 2012 Oct 15;189(8):3822-30.
Gene deregulation and chronic activation in natural killer cells deficient in the transcription factor ETS1. Ramirez K, Chandler KJ, Spaulding C, Zandi S, Sigvardsson M, Graves BJ, Kee BL. Immunity. 2012 Jun 29;36(6):921-32.

2011

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Mandal M, Powers SE, Maienschein-Cline M, Bartom ET, Hamel KM, Kee BL, Dinner AR, Clark MR. Nat Immunol. 2011 Oct 30;12(12):1212-20. .
A comprehensive transcriptional landscape of human hematopoiesis. Kee BL. Cell Stem Cell. 2011 Feb 4;8(2):122-4.

2010

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K. Immunity. 2010 Nov 24;33(5):685-98.
E proteins and the regulation of early lymphocyte development. de Pooter RF, Kee BL. Immunol Rev. 2010 Nov;238(1):93-109.
SAP protein-dependent natural killer T-like cells regulate the development of CD8(+) T cells with innate lymphocyte characteristics. Verykokakis M, Boos MD, Bendelac A, Kee BL. Immunity. 2010 Aug 27;33(2):203-15.
Multiple hats for natural killers. Ramirez K, Kee BL. Curr Opin Immunol. 2010 Apr;22(2):193-8.
Inhibitor of DNA binding 3 limits development of murine slam-associated adaptor protein-dependent “innate” gammadelta T cells. Verykokakis M, Boos MD, Bendelac A, Adams EJ, Pereira P, Kee BL. PLoS One. 2010 Feb 19;5(2):e9303.

2009

E and ID proteins branch out. Kee BL. Nat Rev Immunol. 2009 Mar;9(3):175-84.

2008

Transcriptional regulation of lymphocyte development. Dias S, Xu W, McGregor S, Kee B. Curr Opin Genet Dev. 2008 Oct;18(5):441-8.
E2A proteins promote development of lymphoid-primed multipotent progenitors. Dias S, Månsson R, Gurbuxani S, Sigvardsson M, Kee BL. Immunity. 2008 Aug 15;29(2):217-27.
Extrinsic and intrinsic regulation of early natural killer cell development. Boos MD, Ramirez K, Kee BL. Immunol Res. 2008;40(3):193-207.
Differential roles for the E2A activation domains in B lymphocytes and macrophages. Bhalla S, Spaulding C, Brumbaugh RL, Zagort DE, Massari ME, Murre C, Kee BL. J Immunol. 2008 Feb 1;180(3):1694-703.

2007

Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Spaulding C, Reschly EJ, Zagort DE, Yashiro-Ohtani Y, Beverly LJ, Capobianco A, Pear WS, Kee BL. Blood. 2007 Oct 1;110(7):2650-8.
The transcriptional regulation of B cell lineage commitment. Nutt SL, Kee BL. Immunity. 2007 Jun;26(6):715-25.
Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. Boos MD, Yokota Y, Eberl G, Kee BL. J Exp Med. 2007 May 14;204(5):1119-30.
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas. Xu W, Kee BL. Blood. 2007 May 15;109(10):4406-14.

2006

Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL. Blood. 2006 May 15;107(10):4115-21.

2005

Id3 induces growth arrest and caspase-2-dependent apoptosis in B lymphocyte progenitors. Kee BL. J Immunol. 2005 Oct 1;175(7):4518-27.
Lymphoid development: it’s not ‘all Greek to us’ any more. Osborne BA, Kee BL. Nat Immunol. 2005 Feb;6(2):119-23.

2004

Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. Seet CS, Brumbaugh RL, Kee BL. J Exp Med. 2004 Jun 21;199(12):1689-700.