Registry for Research on Hormonal Transplacental Carcinogenesis


Breast Cancer: Mortality in women given diethylstilbestrol during pregnancy.Titus-Ernstoff L, Troisi R, Hatch EE, Palmer JR, Wise LA, Ricker W, Hyer M, Kaufman R, Noller K, Strohsnitter W, Herbst AL, Hartge P, Hoover RN. Br J Cancer. 2006 Jul 3;95(1):107-11.

Due to the advanced age of the Mothers Cohort, they have not been actively followed since 1994, so survival was assessed through a search of the National Death Index. The results suggested a modest increase in death from breast cancer in the DES-exposed mothers, compared to the unexposed. We did not, however, see an excess of overall mortality in DES-exposed mothers, or an excess of death from any specific cause other than breast cancer. In particular, DES was not associated with an increased mortality from gynecologic cancers.