Title: Prefrontal cortical representations associated with learning multiple tasks
Nan Zhou, doctoral student in the Yu Lab, Department of Psychology, University of Chicago
Abstract: Why are some tasks harder to learn than others? What neural mechanisms differentiate success from failure in task learning? Memory processes require interactions between the hippocampus (HPC) and prefrontal cortex (PFC). Theta rhythms and sharp wave ripples (SWR) are key physiological mechanisms thought to mediate this coordination. We designed a study where rats learn two maze tasks in an interleaved manner. Rats performed well in one task but poorly in another. In this talk, I will discuss how the hippocampal-prefrontal network supports learning of multiple tasks. Specifically, I will examine HPC-PFC coordination and PFC task representations across learning. First, I will show how HPC-PFC coordination dynamically changes during theta rhythms and SWRs. Next, I will show that PFC exhibits a dominant and stable task representation only in the well learned task. Our results suggest that successful task learning is linked to a dominant, and stable task representation.
Time: 12/10/25, 3:30 PM
Location: Biopsychological Sciences Building Room 122
If you have any questions, requests, or concerns, please contact Cambria Revsine (crevsine [at] uchicago [dot] edu) or Huiqin Chen (huiqinchen [at] uchicago [dot] edu).