Projects (Internal/non-NIH Funding):

  • Proliferation and Nano-particle sensitizing agents. Chin-Tu Chen, Ph.D., PI. (18F-FLT)
  • Total bone marrow irradiation in addition to fludarabine/melphalan conditioning. Hongtau Liu, M.D., PI. (18F-FLT, human use under a UC held IND).
  • Image-Guided Precision Radiotherapy of Hypoxic Tumors. Howard Halpern, M.D. & Chin-Tu Chen, Ph.D., co-PIs. (18F-Miso)
  • Pin 1 Marker for Pancreatic Cancer (with UIC).
  • Development of 18F – NaBF(with UIC).
  • Multiple Sclerosis Imaging Marker. Pedro Brugarolas, Ph.D., PI. (18F-3F4AP)
  • Development of 11C-PIB for clinical research use, Richard Freifelder, Ph.D., PI (11C-PIB)
  • Investigation of 48V labeled VO(acac)2 for Cancer Imaging, Chin-Tu Chen, Ph.D., PI (48VO(acac)2).
  • Nose to Brain Delivery of Insulin Growth Factor 1, Richard Kraig, Ph.D., PI.
  • Development of a novel glucocorticoid radiotracer as a predictive and pharmacodynamic biomarker for glucocorticoid receptor expressing (GR-positive) malignancies, Russell Szmulewitz, M.D PI.

Grants (External Funding):

  • R01/S1 NS093908 (Carroll/Christoforidis). Development of Novel MR Imaging for Ischemia Stroke Evaluation.
  • R01 DA044760 (Green/Chen/Mukherjee). PET Imaging of α4β2 Nicotinic Receptor Upregulation and Smoking Cessation.
  • R01 DA044760-02S1 (Green/Chen/Mukherjee).  Supplemental grant for adding an Alzheimer’s imaging agent to the R01 grant above.
  • DP2 GM128199 (Moellering). Targeting Transcription with Synthetic Biologicals.
  • R01 CA098575 (Halpern). Radiation Biology of EPR Oxygen Images.
  • R01 CA236385 (Chen/Hapern/Karczmar). Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, & MR Imaging. Pending.

  • P. Brugarolas, R. Freifelder, S.-H. Cheng, O. de Jesus. Synthesis of 3-[18F]fluoro-4-aminopyridine from pyridine N-oxide precursors, Chem. Comm. 52 (2016) pp. 7150-7152.
  • P. Brugarolas, M.P.I. Bhuiyan, A. Kucharski, R. Freifelder. Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging De- myelinating Diseases, J. Vis.Exp. 123 (2017) e55537.
  • Brugarolas, P., Sánchez-Rodríguez, J.E., Tsai, H.-M., Basuli, F., Cheng, S.-H., Zhang, X., Caprariello, A.V., Lacroix, J.J., Freifelder, R., Murali, D., DeJesus, O., Miller,R.H., Swenson, R.E., Chen, C.-T., Herscovitch, P., Reich, D.S., Bezanilla, F., and Popko, B.: Development of a PET radioligand for potassium channels to image CNS demyelination. Scientific Reports, 8 (2018) 607.

Talks/Presentations (Invited):

  • Molecular imaging for intranasal drug development, L. Leoni, 2016 Midwest Preclinical Imaging Consortium University of Wisconsin – Madison, Madison, WI, May 15-17, 2016.
  • Molecular Imaging: At the Forefront of Medicine, But Firmly Rooted in Nuclear Physics, R. Freifelder, QCD Thermodynamics – Pressure and Passion, Schloss Waldthausen, Germany, Aug. 24-26, 2016.
  • Integrative Multi-Modality Molecular Imaging: Recent Progress at the UChicago, C.-T. Chen, Research Seminar, Gordon Center for Imaging Science, Massachusetts General Hospital/Harvard University Medical School, Boston MA, September 6, 2016.
  • Two Case Studies: Cyclotrons and cGMP Production Facilities for Two Universities, R, Freifelder, ISPE Annual Meeting, Atlanta, Sept. 18-21, 2016.
  • iSAIRR and Cyclotron Facilities. L. Leoni, 2017 Midwest Preclinical Consortium, Vanderbilt University, Nashville, TN, May 14-16, 2017.
  • Atoms for Peace in Medicine and Biology, C.-T. Chen, CP-1 Commemoration Event – The University of Chicago, Physics Colloquia, Chicago, IL Nov. 2, 2017.
  • Molecular Imaging & Theranostics with An Example of PRINT (Precision-RadioImmuno-NanoTheranostics), C.-T. Chen, Development Center for Biotechnology, Taipei, Taiwan, Dec. 12, 2017.
  • RadioTheranostic Strategies for Improving NSCLC Treatment Outcomes, C.-T. Chen, UChicago Comprehensive Cancer Center, Translational Seminar, Chicago, IL, Dec. 15, 2017.
  • Assessment of Photodynamic Therapy Efficacy of X-ray Activated Nanoscintillators Using 18F-FLT, H.-M. Tsai,  2018 Fourth Annual Invicro Software User Meeting, Boston MA, September 28, 2018.
  • Clinical Molecular Imaging – Firmly Rooted in Nuclear PhysicsR. Freifelder, Physics Colloquium, George Washington University, Washington DC, February 28, 2019. 
  • The University of Chicago Cyclotron Facility and cGMP Radiotracer Production, R. Freifelder, 2019 Molecular Imaging Instrumentation Conference, Hong Kong, April 24-25, 2019.

  • 48-V labeled VO(acac)2 for hybrid PET/MR imaging of cancer,  Brittany Broder,, 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.
  • Preliminary Investigation of Hypoxia within Tumors Using EPRI, DCE‑MRI, and PET‑CT with 18F‑FMISO to Improve Radiotherapy, Inna Gertsenshteyn,, 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Assessment of Photodynamic Therapy (PDT) Efficacy of X‑ray Activated Nanoscintillators Using 18-F FLT in PET,  Lara Leoni et. al.,  2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Investigation of the binding kinetics of nicotinic acetylcholine receptors by PET/CT using fluorine‑18 labeled Nifene and 2‑Fluoro‑3‑(2(S)‑azetidinylmethoxy)pyridine,  Hannah J Zhang, Samuel Mitchell, et. al., 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

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