Recent Publications:

2018

Emmanuel A.O., Arnovitz S., Haghi L., Mathur P.S.,Mondal S., Quandt J., Okoreeh M.K., Maienschein-Cline M., Khazaie K., Dose M. and GounariF.Tcf-1 and HEB cooperate to establish the epigenetic and transcription profile of CD4⁺CD8⁺thymocytesNature Immunol. 19: 1366-1378. PDF

Khan M.W., Saadalla A., Ewida A.H., Al-Katranji K., Al-Saoudi G., Giaccone Z.T., Gounari F., Zhang M., Frank D.A. andKhazaie K. The Stat3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer Cancer Immunol. Immunother. 67 (1), 13-23. PDF

Saadala A., Osman A., Gurish M.F., Dennis K.L., Blatner N.R., Pezeshki A., McNagny K.M., Cheroutre H., Gounari F. and Khazaie K. Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proc. Natl. Acad. Sci. U S A.115 (7), 1588-1592. PDF

2019

MandalM., Okoreeh M.K., Kennedy D.E., Maienschein-ClineM., Ai J., McLeanK.C., Kaverina N., VeselitsM., Schlissel M.S., AifantisI., GounariF. and Clark M.R. CXCR4 signaling dictates the transcriptional and epigenetic landscape of late B lymphopoiesis. Nature Immunology 20, pages 1393–1403. PDF

Yoshida T., Snippert H.J., Hu Y., Emmanuel A.O, Zhang Z., Muhire B., Tolstorukov M., Gounari F. and Georgopoulos K. Pre-B cell differentiation requires functional interaction between the chromatin remodeler Mi-2β and B cell lineage transcription regulators Genes and Development, 33: 1–19. PDF

Yoshida T., Hu Y., Zhang Z., Emmanuel A.O., Galani K., Muhire B., Snippert H.J., Williams C.J., Tolstorukov M.Y., Gounari F. and Georgopoulos K. Chromatin restriction by the nucleosome remodeler Mi-2band functional interplay with lineage-specific transcription regulators control B cell differentiation. Genes & Development, 33: 763-781. PDF

Saadalla A., Lima M.M., Tsai F., Osman A., Singh M.P., Linden D., Dennis K.L., Haeryfar S.M.M., Gurish M.F., Gounari F. and Khazaie K. Cell intrinsic deregulated ß-catenin signaling promotes expansion of bone marrow derived connective tissue type mast cells, systemic inflammation, and colon cancer. Frontiers in Immunology, 10: 1-13. PDF

2020

Kong D., Wan Q., Li J., Zuo S., Liu G., Liu Q., Wang C., Bai P., Duan S-Z., Zhou B., Gounari F., Lyu A., Lazarus M., Breyer R.M. and Yu Y. DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells Circulation 141: 655-666. PDF

Gounari F. CRELD1 controls T cell homeostasis. Nature Immunology volume 21, pages1480–1482 (2020) PDF

2021

Quandt J., Arnovitz S., Haghi L., Woehlk J., Mohsin A., Okoreeh M., Mathur P.S., Emmanuel A.O., Osman A., Krishnan M., Morin S.B., Pearson A.T., Sweis R., Pekow J., Weber C.R., Khazaie K., Gounari F. Wnt/β-catenin activation epigenetically reprograms Regulatory T cells in IBD and progression to dysplasia.  Nature Immunology 22: 471-484. PDF. Commentary (PDF)