Join the adventure! Let’s craft the very first manuscript of the Zhou Lab!

Research before Independence

Zhou, J., Le, LQ., Zhang, Y., Wells, JA., 2024 A general approach for selection of epitope-directed binders to proteins. Proc. Natl. Acad. Sci. U.S.A. 121 (19) e2317307121.

Lim, AS.*, Zhou, J.*, Martinko, JA., Wang, Y., Filippova, E., Remesh, GS, Liu, J., Leung, KK., Kossiakoff, AA., Evans, JM., Wells AJ. 2022 Targeting a proteolytic neo-epitope for RAS-driven cancer. J. Clin. Investig. 132(4) e154604. (* contributed equally, cover & highlighted)

Zhou, J., Li, S., O’Donovanc, B., Zhou, JY., d, DeRisi, J., Wells, J. 2020 Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. Proc. Natl. Acad. Sci. U.S.A. 117 (41) 25464-25475.

Zhao, N., Chopra, S., Trepka, K., Wang, YH., Sakhamuri, S., Hooshdaran, N., Kim, H., Zhou, J., Lim, SA., Leung, KK., Egusa, EA., Zhu, J., Zhang, L., Foye, A., Sriram, R., Chan, E., Seo, Y., Feng, FY., Small, EJ., Chou, J., Wells, JA., Aggarwal, R., Evans. MJ. 2022 CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, Clin. Cancer Res. 28(14):3066-3075.

Schaefer, K., Lui, I. Byrnes, J., Kang, E., Zhou, J., Weeks, A., Wells, AJ., 2022 Direct identification of proteolytic cleavages on living cells using a glycan tethered peptide ligase. ACS Cent. Sci. 8(10):1447-1456

Zhou, XX., Bracken, CJ., Zhang, KH., Zhou, J., Mou, Y., Wang, L., Chen YF., Leung, KK., Wells, AJ. 2020 Targeting phosphotyrosine in native proteins with conditional, bi-specific antibody traps. J. Am. Chem. Soc. 142, 41, 17703–17713.

Bracken, CJ., Shion, AL., Solomon, P., Rettko, NJ., Nguyen, DP., Zha, BS., Byrnes, JR., Zhou, J., Lui, L., Liu, J., Pance, K., Rosenberg, OS, Zhou, XX., Leung, KK., Wells, JA. 2020 Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat. Chem. Biol. 17: 113-121.

Moroz A., Wang YH., Sharib JM., Wei J., Zhao N., Huang Y., Chen Z., Martinko AJ., Zhou J., Lim SA., Zhang LH., Seo Y., Carlin S., Leung KK., Collisson EA., Kirkwood KS., Wells JA., Evans MJ. 2020 Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer. Clin Cancer Res: PMID: 32341034.

Zhou, J., Du, X., Chen, X., Wang, J., Zhou, N., Wu, D., Xu, B. 2018 Enzymatic Self-Assembly Confers Exceptionally Strong Synergism with NF-kB Targeting for Selective Necroptosis of Cancer Cells. J. Am. Chem. Soc. 140: 2301-2308.

Zhou, J., Du, X., Chen, X., Xu, B. 2018 Adaptive Multifunctional Supramolecular Assemblies of Glycopeptides Rapidly Enable Morphogenesis. Biochemistry 32: 4867-4879.

Zhou, J., Du, X., Berciu, C., Signore, S., Yamagata, N., Rodal, A., Nicastro, D., Xu, B. 2017 Cellular Uptake of A Taurine Modified, Ester Bond Decorated D-Peptide Derivative via Dynamin Dependent Endocytosis and Macropinocytosis. Mol. Ther. 26: 648-658.

Zhou, J., Du X., Wang, J., Yamagata, N., Xu, B. 2016. Enzyme-Instructed Self-Assembly of Peptides Containing Phosphoserine to Form Supramolecular Hydrogels as Potential Soft Biomaterials. Front. Chem. Sci. Eng. 4:509-515

Zhou, J., Li, J., Du, X., Xu, B. 2016. Supramolecular Biofunctional Materials. Biomaterials. 129: 1-27

Zhou, J., Du, X., Gao, Y., Shi, J., and Xu, B. 2014. Aromatic-Aromatic Interactions Enhance Interfiber Contacts for Enzymatic Formation of a Spontaneously Aligned Supramolecular Hydrogel. J. Am. Chem. Soc.136: 2970-2973

Zhou, J., Du, X., Berciu, C., He, H., Shi, J., Nicastro, D., and Xu, B. 2016. Enzyme-Instructed Self-Assembly for Spatiotemporal Profiling of the Activities of Alkaline Phosphatases on Live Cells. CHEM1: 246-263

Zhou, J., Du, X., Li, J., Yamagata, N., and Xu, B. 2015. Taurine Boosts Cellular Uptake of Small D-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly. J. Am. Chem. Soc.137: 10040-10043

Zhou, J., Du, X.W., and Xu, B. 2016. Regulating the Rate of Molecular Self-Assembly for Targeting Cancer Cells. Angew. Chem., Int. Ed.55: 5770-5775

Zhou, J., Du, X., Yamagata, N., and Xu, B. 2016. Enzyme-Instructed Self-Assembly of Small D-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells. J. Am. Chem. Soc.138: 3813-3823

Zhou, J., Du, X., and Xu, B. 2015. Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology. Prion9: 110-118

Zhou, J., O’Keeffe, M., Liao, G., Zhao, F., Terhorst, C., and Xu, B. 2016. Design and synthesis of nanofibers of self-assembled de novo glycoconjugates towards mucosal lining restoration and anti-inflammatory drug delivery. Tetrahedron72: 6078-6083

Zhou, J., and Xu, B. 2015. Enzyme-Instructed Self-Assembly: A Multistep Process for Potential Cancer Therapy. Bioconjugate Chem.26: 987-999

Du, X., Zhou, J., Wang, H., Shi, J., Kuang Y., Zeng, W., Yang, Z., Xu, B. 2017 In Situ Generated D‐Peptidic Nanofibrils as Multifaceted Apoptotic Inducers to Target Cancer Cells. Cell Death Dis. (in press)

Du, X., Zhou, J., Guvench, O., Sangiorgi, F.O., Li, X., Zhou, N., and Xu, B. 2014. Supramolecular Assemblies of a Conjugate of Nucleobase, Amino Acids, and Saccharide Act as Agonists for Proliferation of Embryonic Stem Cells and Development of Zygotes. Bioconjugate Chem.25: 1031-1035

Du, X., Zhou, J., Shi, J., and Xu, B. 2015. Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials. Chem. Rev.115: 13165-13307

Du, X., Zhou, J., Wu, L., Sun, S., and Xu, B. 2014. Enzymatic Transformation of Phosphate Decorated Magnetic Nanoparticles for Selectively Sorting and Inhibiting Cancer Cells. Bioconjugate Chem.25: 2129-2133

Du, X., Zhou, J., and Xu, B. 2014. Supramolecular Hydrogels Made of Basic Biological Building Blocks. Chem. Asian J.9: 1446-1472

Du, X., Zhou, J., and Xu, B. 2015. Ectoenzyme switches the surface of magnetic nanoparticles for selective binding of cancer cells. J. Colloid Interface Sci.447: 273-277

Du, X., Zhou, J., Zhou, R., and Xu, B. 2016. Chirality Controls Reaction-Diffusion of Nanoparticles for Inhibiting Cancer Cells. ChemNanoMat : 17-21

Zhou, R., Kuang, Y., Zhou, J., Du, X.W., Li, J., Shi, J.F., Haburcak, R., and Xu, B. 2016. Nanonets Collect Cancer Secretome from Pericellular Space. Plos One11

Yuan, D., Du, X., Shi, J., Zhou, N., Zhou, J., and Xu, B. 2015. Mixing Biomimetic Heterodimers of Nucleopeptides to Generate Biocompatible and Biostable Supramolecular Hydrogels. Angew. Chem., Int. Ed.54: 5705-5708

Wu, D.-D., He, M.-T., Liu, Q.-D., Wang, W., Zhou, J., Wang, L., Fun, H.-K., Xu, J.-H., and Zhang, Y. 2012. Photoinduced reactions of bicycloalkylidenes with isatin and isoquinolinetrione. Org. Biomol. Chem.10: 3626-3635

Wu, D., Zhou, J., Shi, J., Du, X., and Xu, B. 2014. A naphthalene-containing amino acid enables hydrogelation of a conjugate of nucleobase-saccharide-amino acids. Chem. Commun.50: 1992-1994

Wu, D., Du, X., Shi, J., Zhou, J., Zhou, N., and Xu, B. 2015. The first CD73-instructed supramolecular hydrogel. J. Colloid Interface Sci.447: 269-272

Wu, D., Du, X., Shi, J., Zhou, J., and Xu, B. 2014. Supramolecular Nanofibers/Hydrogels of the Conjugates of Nucleobase, Saccharide, and Amino Acids. Chin. J. Chem.32: 313-318

Wang, H., Feng, Z., Wu, D., Fritzsching, K.J., Rigney, M., Zhou, J., Jiang, Y., Schmidt-Rohr, K., and Xu, B. 2016. Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells. J. Am. Chem. Soc.138: 10758-10761

Shi, J., Du, X., Yuan, D., Zhou, J., Zhou, N., Huang, Y., and Xu, B. 2014. D-Amino Acids Modulate the Cellular Response of Enzymatic-Instructed Supramolecular Nanofibers of Small Peptides. Biomacromolecules15: 3559-3568

Shi, J., Du, X., Huang, Y., Zhou, J., Yuan, D., Wu, D., Zhang, Y., Haburcak, R., Epstein, I.R., and Xu, B. 2015. Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules To Induce Cell Necroptosis. J. Am. Chem. Soc.137: 26-29

Li, J., Kuang, Y., Shi, J., Zhou, J., Medina, J.E., Zhou, R., Yuan, D., Yang, C., Wang, H., Yang, Z., et al. 2015. Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells. Angew. Chem. Int. Edit.54: 13307-13311

Li, J., Kuang, Y., Shi, J., Yuan, G., Zhou, J., and Xu, B. 2013. The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels. Beilstein J. Org. Chem.9: 908-917, No 104

Li, J., Gao, Y., Kuang, Y., Shi, J., Du, X., Zhou, J., Wang, H., Yang, Z., and Xu, B. 2013. Dephosphorylation of d-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy. J. Am. Chem. Soc.135: 9907-9914

Laverty, G., McCloskey, A.P., Gilmore, B.F., Jones, D.S., Zhou, J., and Xu, B. 2014. Ultrashort Cationic Naphthalene-Derived Self-Assembled Peptides as Antimicrobial Nanomaterials. Biomacromolecules 15: 3429-3439

Kuang, Y., Long, M.J.C., Zhou, J., Shi, J., Gao, Y., Xu, C., Hedstrom, L., and Xu, B. 2014. Prion-like Nanofibrils of Small Molecules (PriSM) Selectively Inhibit Cancer Cells by Impeding Cytoskeleton Dynamics. J. Biol. Chem.289: 29208-29218

Kuang, Y., Du, X., Zhou, J., and Xu, B. 2014. Supramolecular nanofibrils inhibit cancer progression in vitro and in vivo. Adv. Healthc. Mater.3: 1217-1221

Huang, C.M., Yu, H.T., Miao, Z.R., Zhou, J., Wang, S.A., Fun, H.K., Xu, J.H., and Zhang, Y. 2011. Facile synthesis of spiroisoquinolines based on photocycloaddition of isoquinoline-1,3,4-trione with oxazoles. Org. Biomol. Chem.9: 3629-3631

Gao, Y., Kuang, Y., Du, X., Zhou, J., Chandran, P., Horkay, F., and Xu, B. 2013. Imaging self-assembly dependent spatial distribution of small molecules in a cellular environment. Langmuir 29: 15191-15200

Yang, C., Ren, C., Zhou, J., Liu, J., Zhang, Y., Huang, F., Ding, D., Xu, B., Liu, J. 2017 Dual Fluorescent-Nuclear and Self-Assembling Vancomycin for in vivo Imaging of Bacterial Infections  Angew. Chem. Int. Ed. 56: 2356-2360

McCloskey, A., Gilmore S., Zhou, J., Draper, E., Porter S., Gilmore, B., Xu, B., Laverty, G. 2016 Self-assembling ultrashort NSAID-peptide nanosponges: multifunctional antimicrobial and anti-inflammatory materials. RSC Adv. 6: 114738-114749

Safavi, A., Ahmadi, R., Mohammadpour, Z., Zhou, J. 2016 Fluorescent pH nanosensor based on carbon nanodots for monitoring minor intracellular pH changes. RSC Adv. 6: 104657–104664