The presence of B cell follicles in iBALT is associated with protection in TB, but the mechanism behind the functional role of B cells in TB is still lacking. Mice lacking B cells are more susceptible to Mtb infection, and show greater immunopathology, indicating that B cells have a protective role in Mtb infection. Our aim is to further elucidate and identify the roles B cells are playing in protection against Mtb infection. To accomplish our aim, we will use different Mtb-infected mouse strains lacking particular B cell subsets or functions, and characterize their response to Mtb infection. Ultimately, our objective is to understand the mechanisms through which B cells can protect against Mtb infection, and identify targets which we can utilize to combat TB.