PUBLICATIONS
2024
Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis. Gupta A , Thirunavukkarasu S , Rangel-Moreno J , Ahmed M , Swanson RV, Mbandi SK , Smrcka AV , Kaushal D , Scriba TJ, Khader SA. mBio.2024 Apr 9;92(4):e0049523.doi: 10.1128/iai.00495-23. Epub 2024 Mar 7.
Lung type 3 innate lymphoid cells respond early following Mycobacterium tuberculosis infection . Das S, Chauhan KS, Ahmed M, Akter S, Lu L , Rosa BA, Colonna M, Khader SA. mBio.2024 Apr 10;15(4):e0329923. doi: 10.1128/mbio.03299-23. Epub 2024 Feb 26. PMID: 38407132
NF-κb signaling deficiency in CD11c-expressing phagocytes mediates early inflammatory responses and enhances Mycobacterium tuberculosis control . Chauhan KS, Dunlap M, Akter S, Gupta A Ahmed M, Rosa BA, Dela Pena NB, Mitreva M, Khader SA. The Journal of Infectious Diseases. 2024, jiae060.
Saponin TQL1055 adjuvant-containing vaccine confers protection upon Mycobacterium tuberculosis challenge in mice. Ahmed M, Farris E, , Swanson RV, Das S, Yang Y, Martin T, Khader SA. Hum Vaccin Immunother. 2024 Dec 31; 20(1):2302070. doi: 10.1080/21645515.2024.2302070. Epub 2024 Jan 8. PMID: 38190806
2023
Elevated level of circulating but not urine S100A8/A9 identifies poor COVID-19 outcomes. Mellet L, Amarsinghe G, Farnsworth CF, Khader SA. ACS Infect Dis.2023 Oct 13;9(10):1815-1820. doi: 10.1021/acsinfecdis.3c00249. Epub 2023 Oct 3. PMID: 37787461
Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells. Bobba S, Howard NC, Das S, Ahmed M, Khan N, Marchante I, Barreiro LB, Sanz J, Divangahi M, Khader SA. Infect Immun. 2023 Sep 27:e0020123. doi: 10.1128/iai.00201-23. Epub ahead of print. PMID: 37754680
Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye. Trends Immunol. 2023 Sep;44(9):712-723. doi: 10.1016/j.it.2023.07.003. Epub 2023 Aug 3. PMID: 37543504 Review.
A protocol to analyze single-cell RNA-seq data from Mycobacterium tuberculosis-infected mice lung. STAR Protoc. 2023 Aug 31;4(3):102544. doi: 10.1016/j.xpro.2023.102544. Online ahead of print. PMID: 37659083
Poly(ADP)ribose polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production. Thirunavukkarasu S, Ahmed M, Rosa BA, Boothby M, Cho SH, Rangel-Moreno J, Mbandi SK, Schreiber V, Gupta A, Zúñiga J, Mitreva M, Kaushal D, Scriba TJ, Khader SA. J Clin Invest. 2023 May 18:e158630. doi: 10.1172/JCI158630. PMID: 37200107
Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control. Swanson RV, Gupta A, Foreman TW, Lu L, Choreno-Parra JA, Mbandi SK, Rosa BA, Akter S, Das S, Ahmed M, Garcia-Hernandez ML, Singh DK, Esaulova E, Artyomov MN, Gommerman J, Mehra S, Zuniga J, Mitreva M, Scriba TJ, Rangel-Moreno J, Kaushal D, Khader SA. Nat Immunol. 2023 May;24(5):855-868. doi: 10.1038/s41590-023-01476-3. Epub 2023 Apr 3. PMID: 37012543
2022
Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity. Bucşan AN, Veatch A, Singh DK, Akter S, Golden NA, Kirkpatrick M, Threeton B, Moodley C, Ahmed M, Doyle LA, Russell-Lodrigue K, Norton EB, Didier PJ, Roy CJ, Abramovitch RB, Mehra S, Khader SA, Kaushal D. Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts Mycobacterium tuberculosis Pathogenicity. Am J Respir Crit Care Med. 2022 Jul 1;206(1):94-104. doi: 10.1164/rccm.202112-2747OC. PMID: 35412961.
Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report. Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD. Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 Jul;67(1):e1-18. doi: 10.1165/rcmb.2022-0167ST. PMID: 35776495; PMCID: PMC9273224.
Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Downey J, Randolph HE, Pernet E, Tran KA, Khader SA, King IL, Barreiro LB, Divangahi M. Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Cell Rep. 2022 Jun 21;39(12):110974. doi: 10.1016/j.celrep.2022.110974. PMID: 35732121.
Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes. Akter S, Chauhan KS, Dunlap MD, Choreño-Parra JA, Lu L, Esaulova E, Zúñiga J, Artyomov MN, Kaushal D, Khader SA. Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes. Cell Rep. 2022 Jun 21;39(12):110983. doi: 10.1016/j.celrep.2022.110983. PMID: 35732116.
Inflammatory comorbidities: to train or not to train? Suhas Bobba, Shabaana A. Khader, Inflammatory comorbidities: to train or not to train?, Trends in Immunology, ISSN 1471-4906, https://doi.org/10.1016/j.it.2022.04.005. Available online, 8 May, 2022.
The immunoregulatory landscape of human tuberculosis granulomas. McCaffrey EF, Donato M, Keren L, Chen Z, Delmastro A, Fitzpatrick MB, Gupta S, Greenwald NF, Baranski A, Graf W, Kumar R, Bosse M, Fullaway CC, Ramdial PK, Forgó E, Jojic V, Van Valen D, Mehra S, Khader SA, Bendall SC, van de Rijn M, Kalman D, Kaushal D, Hunter RL, Banaei N, Steyn AJC, Khatri P, Angelo M. Author Correction: The immunoregulatory landscape of human tuberculosis granulomas. Nat Immunol. 2022 Mar 11. doi: 10.1038/s41590-022-01178-2. Epub ahead of print. Erratum for: Nat Immunol. 2022 Feb;23(2):318-329. PMID: 35277696.
Corrigendum to “Rifampicin resistance mutations in the rpoB gene of Enterococcus faecalis affect the production of cytokines by host macrophages” Urusova DV, Merriman JA, Gupta A, Chen L, Mathema B, Caparon MG, Khader SA. Corrigendum to “Rifampicin resistance mutations in the rpoB gene of Enterococcus faecalis affect the production of cytokines by host macrophages” Cytokine 151 (2022) 155788. Cytokine. 2022 Apr;152:155845. doi: 10.1016/j.cyto.2022.155845. Epub 2022 Mar 4. Erratum for: Cytokine. 2022 Mar;151:155788. PMID: 35256256.
Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model. Gomez M, Ahmed M, Das S, McCollum J, Mellett L, Swanson R, Gupta A, Carrigy NB, Wang H, Barona D, Bachchhav S, Gerhardt A, Press C, Archer MC, Liang H, Seydoux E, Kramer RM, Kuehl PJ, Vehring R, Khader SA, Fox CB. Development and Testing of a Spray-Dried Tuberculosis Vaccine Candidate in a Mouse Model. Front Pharmacol. 2022 Jan 21;12:799034. doi: 10.3389/fphar.2021.799034. PMID: 35126135; PMCID: PMC8814656.
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2. Singh DK, Aladyeva E, Das S, Singh B, Esaulova E, Swain A, Ahmed M, Cole J, Moodley C, Mehra S, Schlesinger LS, Artyomov MN, Khader SA, Kaushal D. Myeloid cell interferon responses correlate with clearance of SARS-CoV-2. Nat Commun. 2022 Feb 3;13(1):679. doi: 10.1038/s41467-022-28315-7. PMID: 35115549; PMCID: PMC8814034.
The immunoregulatory landscape of human tuberculosis granulomas. McCaffrey EF, Donato M, Keren L, Chen Z, Delmastro A, Fitzpatrick MB, Gupta S, Greenwald NF, Baranski A, Graf W, Kumar R, Bosse M, Fullaway CC, Ramdial PK, Forgó E, Jojic V, Van Valen D, Mehra S, Khader SA, Bendall SC, van de Rijn M, Kalman D, Kaushal D, Hunter RL, Banaei N, Steyn AJC, Khatri P, Angelo M. The immunoregulatory landscape of human tuberculosis granulomas. Nat Immunol. 2022 Feb;23(2):318-329. doi: 10.1038/s41590-021-01121-x. Epub 2022 Jan 20. PMID: 35058616; PMCID: PMC8810384.
Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production Urusova DV, Merriman JA, Gupta A, Chen L, Mathema B, Caparon MG, Khader SA. Rifampin resistance mutations in the rpoB gene of Enterococcus faecalis impact host macrophage cytokine production. Cytokine. 2022 Mar;151:155788. doi: 10.1016/j.cyto.2021.155788. Epub 2022 Jan 11. Erratum in: Cytokine. 2022 Mar 4;:155845. PMID: 35030469.
2021
Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas Singh B, Singh DK, Ganatra SR, Escobedo RA, Khader S, Schlesinger LS, Kaushal D, Mehra S. mBio. 2021 Dec 21;12(6):e0318921. doi: 10.1128/mbio.03189-21. Epub 2021 Dec 14. PMID: 34903057; PMCID: PMC8669465.
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a tuberculosis/simian immunodeficiency virus coinfection model Sharan R, Ganatra SR, Bucsan AN, Cole J, Singh DK, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick EJ Jr, Hall-Ursone S, Khader SA, Mehra S, Rengarajan J, Kaushal D. J Clin Invest. 2021 Dec 2:e153090. doi: 10.1172/JCI153090. Epub ahead of print. PMID: 34855621.
NIAID workshop on secondary vaccine effects Secondary Vaccine Effects Workshop Planning Committee: Aaron M. Joffe, Eun-Chung Park, Alison Augustine, Chao Jiang, Mercy PrabhusDas, Nancy Vazquez-Maldonado, Peter Aaby, Galit Alter, Maziar Divangahi, Peter Hotez, Shabaana Khader, Mihai G. Netea, William A Petri Jr., Stanley Plotkin, Kimberly M Thompson. Nat Immunol. 2021 Nov;22(11):1363-1366. doi: 10.1038/s41590-021-01054-5. PMID: 34686866.
S100A8/A9 in COVID-19 pathogenesis: Impact on clinical outcomes Leah Mellett, Shabaana A. Khader. Elsevier, October 17, 2021. Cytokine & Growth Factor Reviews, ISSN 1359-6101,
https://doi.org/10.1016/j.cytogfr.2021.10.004.
CXCL17 Is Dispensable during Hypervirulent Mycobacterium tuberculosis HN878 Infection in Mice José Alberto Choreño-Parra, Micah D. Dunlap, Rosemary Swanson, Luis A. Jiménez-Álvarez, Marcela Muñoz-Torrico, Silvia Guzmán-Beltrán, Joaquín Zúñiga, Shabaana A. Khader. ImmunoHorizons September 1, 2021, 5 (9) 752-759; DOI: 10.4049/immunohorizons.2100048
Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4 + T Cell Activation and Mycobacterium tuberculosis Control Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA. Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4+ T Cell Activation and Mycobacterium tuberculosis Control. mBio. 2021 Jul 13:e0146821. doi: 10.1128/mBio.01468-21. Epub ahead of print. PMID: 34253059.
Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis Choreño-Parra JA, Jiménez-Álvarez LA, Maldonado-Díaz ED, Cárdenas G, Fernández-Lopez LA, Soto-Hernandez JL, Muñoz-Torrico M, Ramírez-Martínez G, Cruz-Lagunas A, Vega-López A, Domínguez-López ML, Sánchez-Garibay C, Guadarrama-Ortíz P, Giono S, Jiménez-Zamudio LA, Khader SA, García-Latorre EA, Salinas-Lara C, Zúñiga J. Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis. J Immunol Res. 2021 Apr 27;2021:5517856. doi: 10.1155/2021/5517856. PMID: 34007850; PMCID: PMC8100419.
Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics Chumakov K, Avidan MS, Benn CS, Bertozzi SM, Blatt L, Chang AY, Jamison DT, Khader SA, Kottilil S, Netea MG, Sparrow A, Gallo RC. Old vaccines for new infections: Exploiting innate immunity to control COVID-19 and prevent future pandemics. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2101718118. doi: 10.1073/pnas.2101718118. PMID: 34006644; PMCID: PMC8166166.
Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1) Choreño-Parra JA, Jiménez-Álvarez LA, Cruz-Lagunas A, Rodríguez-Reyna TS, Ramírez-Martínez G, Sandoval-Vega M, Hernández-García DL, Choreño-Parra EM, Balderas-Martínez YI, Martinez-Sánchez ME, Márquez-García E, Sciutto E, Moreno-Rodríguez J, Barreto-Rodríguez JO, Vázquez-Rojas H, Centeno-Sáenz GI, Alvarado-Peña N, Salinas-Lara C, Sánchez-Garibay C, Galeana-Cadena D, Hernández G, Mendoza-Milla C, Domínguez A, Granados J, Mena-Hernández L, Pérez-Buenfil LÁ, Domínguez-Cheritt G, Cabello-Gutiérrez C, Luna-Rivero C, Salas-Hernández J, Santillán-Doherty P, Regalado J, Hernández-Martínez A, Orozco L, Ávila-Moreno F, García-Latorre EA, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1). Front Immunol. 2021 Apr 21;12:593595. doi: 10.3389/fimmu.2021.593595. PMID: 33995342; PMCID: PMC8115405.
Monocyte progenitors give rise to multinucleated giant cells Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P. Nat Commun. 2021 Apr 1;12(1):2027. doi: 10.1038/s41467-021-22103-5. PMID: 33795674; PMCID: PMC8016882.
IFN signaling and neutrophil degranulation transcriptional signatures are induced durings SARS-CoV-2 infection Rosa BA, Ahmed M, Singh DK, Choreño-Parra JA, Cole J, Jiménez-Álvarez LA, Rodríguez-Reyna TS, Singh B, Gonzalez O, Carrion R Jr, Schlesinger LS, Martin J, Zúñiga J, Mitreva M, Kaushal D, Khader SA. Commun Biol. 2021 Mar 5;4(1):290. doi: 10.1038/s42003-021-01829-4. PMID: 33674719; PMCID: PMC7935909.
Expression of Surfactant protein D (SP-D) distinguishes severe pandemic influenza A(H1N1) from COVID-19 Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Cruz-Lagunas A, Thapa M, Fernández-López LA, Carnalla-Cortés M, Choreño-Parra EM, Mena-Hernández L, Sandoval-Vega M, Hernández-Montiel EM, Hernández-García DL, Ramírez-Noyola JA, Reyes-López CE, Domínguez-Faure A, Zamudio-López GY, Márquez-García E, Moncada-Morales A, Mendoza-Milla C, Cervántes-Rosete D, Muñoz-Torrico M, Luna-Rivero C, García-Latorre EA, Guadarrama-Ortíz P, Ávila-Moreno F, Domínguez-Cherit G, Rodríguez-Reyna TS, Mudd PA, Hernández-Cárdenas CM, Khader SA, Zúñiga J. J Infect Dis. 2021 Mar 1:jiab113. doi: 10.1093/infdis/jiab113. Epub ahead of print. PMID: 33668070; PMCID: PMC7989215.
CXCL17 is a Specific Diagnostic Biomarker for Severe Pandemic Influenza A(H1N1) That Predicts Poor Clinical Outcome Choreño-Parra JA, Jiménez-Álvarez LA, Ramírez-Martínez G, Sandoval-Vega M, Salinas-Lara C, Sánchez-Garibay C, Luna-Rivero C, Hernández-Montiel EM, Fernández-López LA, Cabrera-Cornejo MF, Choreño-Parra EM, Cruz-Lagunas A, Domínguez A, Márquez-García E, Cabello-Gutiérrez C, Bolaños-Morales FV, Mena-Hernández L, Delgado-Zaldivar D, Rebolledo-García D, Guadarrama-Ortiz P, Regino-Zamarripa NE, Mendoza-Milla C, García-Latorre EA, Rodiguez-Reyna TS, Cervántes-Rosete D, Hernández-Cárdenas CM, Khader SA, Zlotnik A, Zúñiga J. Front Immunol. 2021 Feb 26;12:633297. doi: 10.3389/fimmu.2021.633297. PMID: 33717172; PMCID: PMC7953906.
Trained immunity, tolerance, priming and differentiation: distinct immunological processes Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenwoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. Nat Immunol. 2021 Jan;22(1):2-6. doi: 10.1038/s41590-020-00845-6. PMID: 33293712.
2020
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets Singh DK, Singh B, Ganatra SR, Gazi M, Cole J, Thippeshappa R, Alfson KJ, Clemmons E, Gonzalez O, Escobedo R, Lee TH, Chatterjee A, Goez-Gazi Y, Sharan R, Gough M, Alvarez C, Blakley A, Ferdin J, Bartley C, Staples H, Parodi L, Callery J, Mannino A, Klaffke B, Escareno P, Platt RN 2nd, Hodara V, Scordo J, Gautam S, Vilanova AG, Olmo-Fontanez A, Schami A, Oyejide A, Ajithdoss DK, Copin R, Baum A, Kyratsous C, Alvarez X, Ahmed M, Rosa B, Goodroe A, Dutton J, Hall-Ursone S, Frost PA, Voges AK, Ross CN, Sayers K, Chen C, Hallam C, Khader SA, Mitreva M, Anderson TJC, Martinez-Sobrido L, Patterson JL, Turner J, Torrelles JB, Dick EJ Jr, Brasky K, Schlesinger LS, Giavedoni LD, Carrion R Jr, Kaushal D. Nat Microbiol. 2021 Jan;6(1):73-86. doi: 10.1038/s41564-020-00841-4. Epub 2020 Dec 18. PMID: 33340034.
The immune landscape in tuberculosis reveals populations linked to disease and latency E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA. Cell Host Microbe. 2020 Dec 16:S1931-3128(20)30635-1. doi: 10.1016/j.chom.2020.11.013. Epub ahead of print. PMID: 33340449.
Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model
Ganatra SR, Bucsan AN, Alvarez X, Kumar S, Chatterjee A, Quezada M, et al. The Journal of clinical investigation. 2020.
Targeting unconventional host components for vaccination-induced protection against TB Elisa Nemes, Shabaana A Khader, Rosemary V Swanson, Willem A Hanekom. Frontiers in Immunology, section Vaccines and Molecular Therapeutics
Formation of lung inducible Bronchus Associated Lymphoid Tissue is regulated by Mycobacterium tuberculosis expressed
Micah Dunlap, Oliver A Prince, Javier Rangel-Moreno, Kimberly Thomas, Julia Scordo, Jordi B Torrelles, Jeffery Cox, Adrie JC Steyn, Joaquín Zúñiga, Deepak Kaushal, Shabaana Khader
Frontiers in Immunology, section Microbial Immunology
The protective and pathogenic roles of CXCL17 in human health and disease: potential in respiratory medicine
Choreño-Parra JA, Thirunavukkarasu S, Zúñiga J, Khader SA.Cytokine Growth Factor Rev. 2020 Apr 23:S1359-6101(20)30044-7. doi: 10.1016/j.cytogfr.2020.04.004. Online ahead of print. PMID: 32345516
Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus
Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N.J Clin Invest. 2020 Jun 1;130(6):2789-2799. doi: 10.1172/JCI136288.PMID: 32420917
Immunometabolism during Mycobacterium tuberculosis infection
Howard NC, Khader SA Trends Microbiol. 2020 May 11:S0966-842X(20)30103-7. doi: 10.1016/j.tim.2020.04.010. Online ahead of print.PMID: 32409147
Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport
Li LX, Hole CR, Rangel-Moreno J, Khader SA, Doering TL.Infect Immun. 2020 May 18:IAI.00288-20. doi: 10.1128/IAI.00288-20. Online ahead of print.PMID: 32423915
Immune correlates of tuberculosis disease and risk translate across species.
Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA. Sci Transl Med. 2020 Jan 29;12(528). pii: eaay0233. doi: 10.1126/scitranslmed.aay0233.PMID: 31996462
2019
Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles in mice.
Alberto Choreño-Parra J,Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zúñiga J, Khader SA. J Infect Dis. 2019 Dec 13. pii: jiz663. doi: 10.1093/infdis/jiz663.PMID: 31832640
Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection.
Bucşan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D. J Clin Invest. 2019 Oct 28. pii: 125810. doi: 10.1172/JCI125810.PMID: 31479428
Targeting innate immunity for tuberculosis vaccination.
Khader SA, Divangahi M, Hanekom W, Hill PC, Maeurer M, Makar KW, Mayer-Barber KD, Mhlanga MM, Nemes E, Schlesinger LS, van Crevel R, Vankalayapati R, Xavier RJ, Netea MG; Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18. J Clin Invest. 2019 Sep 3;129(9):3482-3491. doi: 10.1172/JCI128877. Review.PMID: 31478909
The current state of animal models and genomic approaches towards identifying and validating molecular determinants of Mycobacterium tuberculosis infection and tuberculosis disease.
Bucsan AN, Mehra S, Khader SA, Kaushal D. Pathog Dis. 2019 Jun 1;77(4). pii: ftz037. doi: 10.1093/femspd/ftz037.PMID: 31381766
Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.
Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung’u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA. Nature. 2019 Jun;570(7762):528-532. doi: 10.1038/s41586-019-1276-2. Epub 2019 Jun 5. Erratum in: Nature. 2019 Jul 24.PMID: 31168092
Mucosal-activated invariant T cells do not exhibit significant lung recruitment and proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551.
Bucsan AN, Rout N, Foreman TW, Khader SA, Rengarajan J, Kaushal D. Tuberculosis (Edinb). 2019 May;116S:S11-S18. doi: 10.1016/j.tube.2019.04.006. Epub 2019 Apr 26.PMID: 31072689
Advances in Cardiovascular Disease Lipid Research Can Provide Novel Insights Into Mycobacterial Pathogenesis.
Thirunavukkarasu S, Khader SA. Front Cell Infect Microbiol. 2019 Apr 18;9:116. doi: 10.3389/fcimb.2019.00116. eCollection 2019. Review.PMID: 31058102
Friend or Foe: The Protective and Pathological Roles of Inducible Bronchus-Associated Lymphoid Tissue in Pulmonary Diseases.
Marin ND, Dunlap MD, Kaushal D, Khader SA. J Immunol. 2019 May 1;202(9):2519-2526. doi: 10.4049/jimmunol.1801135. Review.PMID: 31010841
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.
Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS. Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021.PMID: 30726727
The Tale of IL-12 and IL-23: A Paradigm Shift.
Khader SA, Thirunavukkarasu S. J Immunol. 2019 Feb 1;202(3):629-630. doi: 10.4049/jimmunol.1801603. No abstract available.PMID: 30670577
2018
Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA. Nat Microbiol. 2018 Oct;3(10):1099-1108. doi: 10.1038/s41564-018-0245-0. Epub 2018 Sep 17. Erratum in: Nat Microbiol. 2018 Nov;3(11):1327.PMID: 30224802
A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.
Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA. Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub 2018 Aug 16.PMID: 30115997
Aspergillus fumigatus Preexposure Worsens Pathology and Improves Control of Mycobacterium abscessus Pulmonary Infection in Mice.
Monin L, Mehta S, Elsegeiny W, Gopal R, McAleer JP, Oury TD, Kolls J, Khader SA. Infect Immun. 2018 Feb 20;86(3). pii: e00859-17. doi: 10.1128/IAI.00859-17. Print 2018 Mar.PMID: 29263106
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis.
Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi: 10.1073/pnas.1711373114. Epub 2017 Dec 18.PMID: 29255022
2017
Interleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA. JCI Insight. 2017 Oct 5;2(19). pii: 92973. doi: 10.1172/jci.insight.92973.PMID: 28978810
RNA Interference Screening Reveals Host CaMK4 as a Regulator of Cryptococcal Uptake and Pathogenesis.
Srikanta D, Hole CR, Williams M, Khader SA, Doering TL. Infect Immun. 2017 Nov 17;85(12). pii: e00195-17. doi: 10.1128/IAI.00195-17. Print 2017 Dec.PMID: 28970273
Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is Not Reactivated in the Setting of HIV Co-Infection.
Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S. Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19.PMID: 28935575
Dancing with the Stars: Phenolic Glycolipids Partners with Macrophages.
Dunlap MD, Khader SA. Cell Host Microbe. 2017 Sep 13;22(3):249-251. doi: 10.1016/j.chom.2017.08.016.PMID: 28910627
A novel nanoemulsion vaccine induces mucosal Interleukin-17 responses and confers protection upon Mycobacterium tuberculosis challenge in mice.
Ahmed M, Smith DM, Hamouda T, Rangel-Moreno J, Fattom A, Khader SA. Vaccine. 2017 Sep 5;35(37):4983-4989. doi: 10.1016/j.vaccine.2017.07.073. Epub 2017 Jul 31.PMID: 28774560
Yin and yang of interleukin-17 in host immunity to infection.
Das S, Khader S. F1000Res. 2017 May 23;6:741. doi: 10.12688/f1000research.10862.1. eCollection 2017. Review.PMID: 28713557
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.
García-Hernández ML, Uribe-Uribe NO, Espinosa-González R, Kast WM, Khader SA, Rangel-Moreno J. Front Immunol. 2017 May 17;8:563. doi: 10.3389/fimmu.2017.00563. eCollection 2017.PMID: 28567040
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK. Cell Rep. 2017 Mar 28;18(13):3078-3090. doi: 10.1016/j.celrep.2017.03.016.PMID: 28355561
Rationalized design of a mucosal vaccine protects against Mycobacterium tuberculosis challenge in mice.
Ahmed M, Jiao H, Domingo-Gonzalez R, Das S, Griffiths KL, Rangel-Moreno J, Nagarajan UM, Khader SA. J Leukoc Biol. 2017 Jun;101(6):1373-1381. doi: 10.1189/jlb.4A0616-270R. Epub 2017 Mar 3.PMID: 28258153
2016
Cytokines and Chemokines in Mycobacterium tuberculosis Infection.
Racquel Domingo-Gonzalez, Oliver Prince, Andrea Cooper, and SA. Khader. Microbiol Spectr. 2016 Oct;4(5). doi: 10.1128/microbiolspec.TBTB2-0018-2016 PMID: 27763255
Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy.
Kristin L. Griffiths, Mushtaq Ahmed, Shibali Das, Radha Gopal, William Horne, Terry D. Connell,Kelly D. Moynihan, Jay K. Kolls, Darrell J. Irvine, Maxim N. Artyomov, Javier Rangel-Moreno & Shabaana A. Khader. Published 22 Dec 2016 doi: 10.1038/ncomms13894.PMID: 28004802
Computational analysis reveals a key regulator of cryptococcal virulence and determinant of host response.
S.R. Gish, E.J.Maier, B.C.Haynes, F.H.Santiago-Tirado, D.L. Srikanta, C.Z. Ma, L.X. Li, M.Williams, E.C. Crouch, S.A. Khader, M.R. Brent, and T. L. Doering. mBio, 2016 Apr 19;7(2). pii: e00313-16. doi: 10.1128/mBio.00313-16.PMID: 27094327
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
V.Lampropoulou, A.Sergushichev, M.Bambouskova, S.Nair, E.Vincent, E.Loginicheva, L.Cervantes-Barragan, X.Ma, S.Ching-Cheng Huang, C.J. Weinheimer, S.Khader, G.J. Randolph, E.J.Pearce, R.G.Jones, A.Diwan, M.S. Diamond, M.N. Artyomov. Cell Metabolism, 2016 Jul 12;24(1):158-66. doi: 10.1016/j.cmet.2016.06.004.PMID: 27374498
A novel multivalent tuberculosis vaccine confers protection in a mouse model of tuberculosis.
K.L.Griffiths, D.O.Villarreal, D.B. Weiner, S.A. Khader. Hum Vaccin Immunother. 2016 Oct 2;12(10):2649-2653. doi: 10.1080/21645515.2016.1197454.PMID: 27322875