Kron Lab

Read more about our research efforts below:

Cancer Immunotherapy

Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells. Liu Y, Pagacz J, Wolfgeher DJ, Bromerg KD, Gorman JV, Kron SJ. J Immunother Cancer. 2023 Feb;11(2):e005862. doi: 10.1136/jitc-2022-005862.PMID: 36792123

Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization. Liu Y, Betori RC, Pagacz J, Frost GB, Efimova EV, Wu D, Wolfgeher DJ, Bryan TM, Cohen SB, Scheidt KA, Kron SJ. Cell Chem Biol. 2022 Oct 20;29(10):1517-1531.e7. doi: 10.1016/j.chembiol.2022.09.002. Epub 2022 Oct 6.PMID: 36206753

DNA damage response, metabolism, and cellular senescence in cancer

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons. Flor A, Wolfgeher D, Hanakahi LA, Kron SJ. Cell Chem Biol. 2021 Jun 17; 28(6):776-787.e8. doi: 10.1016/j.chembiol.2020.11.011. Epub 2020 Dec 21. PMID: 33352117.

Mevalonate pathway activity as a determinant of radiation sensitivity in head and neck cancer. Ricco N, Flor A, Wolfgeher D, Efimova EV, Ramamurthy A, Appelbe OK, Brinkman J, Truman AW, Spiotto MT, Kron SJ. Mol Oncol. 2019 Sep;13(9):1927-1943. doi: 10.1002/1878-0261.12535. PMID: 31225926

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. Liu Y, Efimova EV, Ramamurthy A, Kron SJ. J Cell Sci. 2019 Jul 1;132(13). pii: jcs229385. doi: 10.1242/jcs.229385. PMID: 31189537

O-GlcNAcylation enhances double-strand break repair, promotes cancer cell proliferation, and prevents therapy-induced senescence in irradiated tumors. Efimova EV, Appelbe OK, Ricco N, Lee SS, Liu Y, Wolfgeher DJ, Collins TN, Flor AC, Ramamurthy A, Warrington S, Bindokas VP, Kron SJ. Mol Cancer Res. 2019 Jun;17(6):1338-1350. doi: 10.1158/1541-7786.MCR-18-1025. PMID: 30885991

A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence. Wu D, Pepowski B, Takahashi S, Kron SJ. BMC Genomics. 2019 Apr 15;20(1):290. doi: 10.1186/s12864-019-5653-x. PMID: 30987592

HMG-CoA reductase inhibition delays DNA Repair and promotes senescence after tumor irradiation. Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ. Mol Cancer Ther. 2018 Feb;17(2):407-418. doi: 10.1158/1535-7163.MCT-17-0288. Epub 2017 Oct 13. PMID: 29030460

A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence. Flor AC, Wolfgeher D, Wu D, Kron SJ. Cell Death Discov. 2017 Oct 30;3:17075. doi: 10.1038/cddiscovery.2017.75. eCollection 2017. PMID: 29090099

Modulation of therapy-induced senescence by reactive lipid aldehydes. Flor AC, Doshi AP, Kron SJ. Cell Death Discov. 2016;2. pii: 16045. PMID: 27453792

Novel Imaging Approaches

TdT-dUTP DSB End Labeling (TUDEL), for Specific, Direct In Situ Labeling of DNA Double Strand Breaks. Lutze J, Warrington SE, Kron SJ. Methods Mol Biol. 2022;2394:299-317. doi: 10.1007/978-1-0716-1811-0_18. PMID: 35094335

UltraPlex Hapten-Based Multiplexed Fluorescent Immunohistochemistry. Levin M, Flor AC, Snyder H, Kron SJ, Schwartz D.Methods Mol Biol. 2021;2350:267-287. doi: 10.1007/978-1-0716-1593-5_17. PMID: 34331291

Multiplexed Tissue Tomography. Phillips EH, Scholten D, Flor AC, Kron SJ, Lee SS.Methods Mol Biol. 2021;2350:77-93. doi: 10.1007/978-1-0716-1593-5_6. PMID: 34331280

Nondestructive, multiplex three-dimensional mapping of immune infiltrates in core needle biopsy. Lee SS, Bindokas VP, Lingen MW, Kron SJ. Lab Invest. 2019 Sep;99(9):1400-1413. doi: 10.1038/s41374-018-0156-y. PMID: 30401959

Multiplex Three-Dimensional Mapping of Macromolecular Drug Distribution in the Tumor Microenvironment. Lee SS, Bindokas VP, Kron SJ. Mol Cancer Ther. 2019 Jan;18(1):213-226. doi: 10.1158/1535-7163.MCT-18-0554. PMID: 30322947

Multiplex three-dimensional optical mapping of tumor immune microenvironment. Lee SS, Bindokas VP, Kron SJ. Sci Rep. 2017 Dec 5;7(1):17031. doi: 10.1038/s41598-017-16987-x. PMID: 29208908