(773) 702-6795 nelson@uchicago.edu


 Kinetic Separation of Oxidative and Non-oxidative Metabolism in Single Phagosomes from Alveolar Macrophages: Impact on Bacterial Killing. Riazanski V, Sui Z, Nelson DJ. iScience. 2020 Nov 1;23(11):101759. doi: 10.1016/j.isci.2020.101759. eCollection 2020 Nov 20.PMID: 33251491 

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Phylogeny and chemistry of biological mineral transport. Schlesinger PH, Braddock DT, Larrouture QC, Ray EC, Riazanski V, Nelson DJ, Tourkova IL, Blair HC. Bone. 2020 Dec;141:115621. doi: 10.1016/j.bone.2020.115621. Epub 2020 Aug 26.PMID: 32858255 Review.

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Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport. Schlesinger PH, Blair HC, Beer Stolz D, Riazanski V, Ray EC, Tourkova IL, Nelson DJ. Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C111-C124. doi: 10.1152/ajpcell.00120.2019. Epub 2019 Sep 18.PMID: 31532718 Free PMC article. Review.

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Support of bone mineral deposition by regulation of pH. Blair HC, Larrouture QC, Tourkova IL, Liu L, Bian JH, Stolz DB, Nelson DJ, Schlesinger PH. Am JPhysiol Cell Physiol. 2018 Oct 1;315(4):C587-C597. doi:10.1152/ajpcell.00056.2018. Epub 2018 Jul 25. PubMed PMID: 30044661; PubMed Central PMCID: PMC6230682.

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Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro. Blair HC, Larrouture QC, Li Y, Lin H, Beer-Stoltz D, Liu L, Tuan RS, RobinsonLJ, Schlesinger PH, Nelson DJ. Tissue Eng Part B Rev. 2017 Jun;23(3):268-280. doi: 10.1089/ten.TEB.2016.0454. Epub 2016 Dec 27. PubMed PMID: 27846781; PubMed
Central PMCID: PMC5467150.

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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis. Meijer L, Nelson DJ, Riazanski V, Gabdoulkhakova AG, Hery-Arnaud G, Le Berre R, Loaëc N, Oumata N, Galons H, Nowak E, Gueganton L, Dorothée G, Prochazkova M, Hall B, Kulkarni AB, Gray RD, Rossi AG, Witko-Sarsat V, Norez C, Becq F, Ravel D, Mottier D, Rault G. Journal of innate immunity. 2016; 8(4):330-49. NIHMSID: NIHMS755621
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TRPC6 channel translocation into phagosomal membrane augments phagosomal function. Riazanski V, Gabdoulkhakova AG, Boynton LS, Eguchi RR, Deriy LV, Hogarth DK, Loaëc N, Oumata N, Galons H, Brown ME, Shevchenko P, Gallan AJ, Yoo SG, Naren AP, Villereal ML, Beacham DW, Bindokas VP, Birnbaumer L, Meijer L, Nelson DJ. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(47):E6486-95.
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Claudin-2-dependent paracellular channels are dynamically gated.
Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR.
eLife. 2015; 4:e09906.
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Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro.
Larrouture QC, Nelson DJ, Robinson LJ, Liu L, Tourkova I, Schlesinger PH, Blair HC.
Physiological reports. 2015; 3(11).
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HEK-293 cells expressing the cystic fibrosis transmembrane conductance regulator (CFTR): a model for studying regulation of Cl- transport.
Domingue JC, Ao M, Sarathy J, George A, Alrefai WA, Nelson DJ, Rao MC.
Physiological reports. 2014; 2(9).
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Quantifying insulin sensitivity and entero-insular responsiveness to hyper- and hypoglycemia in ferrets.
Sui H, Yi Y, Yao J, Liang B, Sun X, Hu S, Uc A, Nelson DJ, Ode KL, Philipson LH, Engelhardt JF, Norris AW.
PloS one. 2014; 9(3):e90519.
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CLC-3 chloride channels moderate long-term potentiation at Schaffer collateral-CA1 synapses.
Farmer LM, Le BN, Nelson DJ.
The Journal of Physiology. 2013; 591(4):1001-15.
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Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus.
Riazanski V, Deriy LV, Shevchenko PD, Le B, Gomez EA, Nelson DJ.
Nat Neurosci. 2011 Apr;14(4):487-94. Epub 2011 Mar 6.
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Compartmentalized cyclic adenosine 3′,5′-monophosphate at the plasma membrane clusters PDE3A and cystic fibrosis transmembrane conductance regulator into microdomains.
Penmatsa H, Zhang W, Yarlagadda S, Li C, Conoley VG, Yue J, Bahouth SW, Buddington RK, Zhang G, Nelson DJ, Sonecha MD, Manganiello V, Wine JJ, Naren AP.
Mol Biol Cell. 2010 Mar;21(6):1097-110. Epub 2010 Jan 20.
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Bepridil and amiodarone simultaneously target the Alzheimer’s disease beta- and gamma-secretase via distinct mechanisms.

Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF.
J Neurosci. 2010 Jun 30;30(26):8974-83.
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Disease-causing mutations in the cystic fibrosis transmembrane conductance regulator determine the functional responses of alveolar macrophages.
Deriy LV, Gomez EA, Zhang G, Beacham DW, Hopson JA, Gallan AJ, Shevchenko PD, Bindokas VP, Nelson DJ.
J Biol Chem. 2009 Dec 18;284(51):35926-38. Epub .


The granular chloride channel ClC-3 is permissive for insulin secretion.  Deriy, L.V., Gomez, E.A.,  Jacobson, D.A., Wang, X..,  Hopson, J.A., Liu, X.Y., Zhang, G., Bindokas, V.P.,  Philipson, L.H., and  Nelson,, D.J.  2009.  Cell Metabolism.


An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function.
Mitchell J, Wang X, Zhang G, Gentzsch M, Nelson DJ, Shears SB.
Curr Biol. 2008 Oct 28;18(20):1600-5.
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Platel-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.
Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, Nelson DJ, Marks J, Jilling T.
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1191-200. Epub 2008 Mar 13.


Spatiotemporal coupling of cAMP transporter to CTFR chloride channel function in the gut epithelia.
Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, Nelson DJ, Marks J, Jilling T.
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1191-200. Epub 2008 Mar 13.
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  CFTR surface expression and chloride currents are decreased by inhibitors of N-WASP and actin polymerization.

 Ganeshan R, Nowotarski K, Di A, Nelson DJ, Kirk KL.

Biochim Biophys Acta. 2007 Feb;1773(2):192-200. Epub 2006 Oct 3.
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CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons.
Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD, Nelson DJ.
Neuron. 2006 Oct 19;52(2):321-33.
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  CFTR regulates phagosome acidification in macrophages and alerts bacterial activity.

Di A, Brown ME, Deriy LV, Li C, Szeto FL, Chen Y, Huang P, Tong J, Naren AP, Bindokas V, Palfrey HC, Nelson DJ.
Nat Cell Biol. 2006 Sep;8(9):933-44. Epub 2006 Aug 20.
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Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions.
Li C, Dandridge KS, Di A, Marrs KL, Harris EL, Roy K, Jackson JS, Makarova NV, Fujiwara Y, Farrar PL, Nelson DJ, Tigyi GJ, Naren AP.
J Exp Med. 2005 October 3; 202(7): 975–986.
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5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Wang CZ, Wang Y, Di A, Magnuson MA, Ye H, Roe MW, Nelson DJ, Bell GI, Philipson LH.
Biochem Biophys Res Commun. 2005 May 20;330(4):1073-9.
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Mutation of critical GIRK subunit residues disrupts N- and C-termini association and channel function.
Sarac R, Hou P, Hurley KM, Hriciste D, Cohen NA, Nelson DJ.
J Neurosci. 2005 Feb 16;25(7):1836-46.
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A process for controlling intracellular bacterial infections induced by membrane injury.
Roy D, Liston DR, Idone VJ, Di A, Nelson DJ, Pujol C, Bliska JB, Chakrabarti S, Andrews NW.
Science. 2004 Jun 4;304(5676):1515-8.
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Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current.
Robinson NC, Huang P, Kaetzel MA, Lamb FS, Nelson DJ.
J Physiol. 2004 Apr 15;556(Pt 2):353-68. Epub 2004 Jan 30.
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Dynamin regulates focal exocytosis in phagocytosing macrophages.
Di A, Nelson DJ, Bindokas V, Brown ME, Libunao F, Palfrey HC.
Mol Biol Cell. 2003 May;14(5):2016-28. Epub 2003 Feb 21.
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  The interaction between syntaxin 1A and cystic fibrosis transmembrane conductance regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions.

Ganeshan R, Di A, Nelson DJ, Quick MW, Kirk KL.
J Biol Chem. 2003 Jan 31;278(5):2876-85. Epub 2002 Nov 22.
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  CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex.

Cormet-Boyaka E, Di A, Chang SY, Naren AP, Tousson A, Nelson DJ, Kirk KL.
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12477-82. Epub 2002 Sep 3.
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  Quantal release of free radicals during exocytosis of phagosomes.

 Di A, Krupa B, Bindokas VP, Chen Y, Brown ME, Palfrey HC, Naren AP, Kirk KL, Nelson DJ.

Nat Cell Biol. 2002 Apr;4(4):279-85.
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Mechanisms of CFTR regulation by syntaxin 1A and PKA.
Chang SY, Di A, Naren AP, Palfrey HC, Kirk KL, Nelson DJ.
J Cell Sci. 2002 Feb 15;115(Pt 4):783-91.
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Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.
Barg S, Huang P, Eliasson L, Nelson DJ, Obermüller S, Rorsman P, Thévenod F, Renström E.
J Cell Sci. 2001 Jun;114(Pt 11):2145-54.
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Calcium-G protein interactions in the regulation of macrophage secretion.
Di A, Krupa B, Nelson DJ.
J Biol Chem. 2001 Oct 5;276(40):37124-32. Epub 2001 Jul 30.
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Oxidants potentiate Ca++ and c-AMP stimulated Cl- secretion in intestinal epithelial T84 cells.
Sugi K, Musch MW, Nelson DJ, and Chang EB.
Gastroenterology.  2001. 120: 89-98
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Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase.
Huang P, Liu J, Di A, Robinson NC, Musch MW, Kaetzel MA, Nelson DJ.
J Biol Chem. 2001 Jun 8;276(23):20093-100. Epub 2001 Mar 26.
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Impermeability of the GIRK2 weaver channel to divalent cations.
Hou P, Di A, Huang P, Hansen CB, Nelson DJ.
Am J Physiol Cell Physiol. 2000 May;278(5):C1038-46.
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Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents.
Naren AP, Di A, Cormet-Boyaka E, Boyaka PN, McGhee JR, Zhou W, Akagawa K, Fujiwara T, Thome U, Engelhardt JF, Nelson DJ, Kirk KL.
J Clin Invest. 2000 Feb;105(3):377-86.
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The inwardly rectifying K(+) channel subunit GIRK1 rescues the GIRK2 weaver phenotype.
Hou P, Yan S, Tang W, Nelson DJ.
J Neurosci. 1999 Oct 1;19(19):8327-36.
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Membrane capacitance changes associated with particle uptake during phagocytosis in macrophages.
Holevinsky KO, Nelson DJ.
Biophys J. 1998 Nov;75(5):2577-86.
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Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatases.
Xie W, Solomons KR, Freeman S, Kaetzel MA, Bruzik KS, Nelson DJ, Shears SB.
J Physiol. 1998 Aug 1;510 ( Pt 3):661-73.








Cytoskeletal actin gates a Cl- channel in neocortical astrocytes.
Lascola CD, Nelson DJ, Kraig RP.
J Neurosci. 1998 Mar 1;18(5):1679-92.]
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Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.
Naren PP, Quick MW, Collawn JF, Nelson DJ, and Kirk KL.
Physiology.1998 September; pp. 10972-10977
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Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms.
Naren AP, Nelson DJ, Xie W, Jovov B, Pevsner J, Bennett MK, Benos DJ, Quick MW, Kirk KL.
Nature. 1997 Nov 20;390(6657):302-5.
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N-type Inactivation in the Mamalian shaker K+ channel Kv1.4
Lee TE, Philipson LH, Nelson DJ
J. Membrane Biol. 1996 Febr; 151, 225-235
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