A trans-synaptic IgLON adhesion molecular complex directly contacts and clusters a nicotinic receptor.
Mialon M, Patrash L, Weinreb A, Özkan E, Bessereau JL, Pinan-Lucarre B.
Biorxiv 2024.09.05.611427 (2024).
Nematode extracellular protein interactome expands connections between signaling pathways.
Nawrocka WI*, Cheng S*, Hao B*, Rosen MC, Cortés E, Baltrusaitis EE, Aziz Z, Kovács IA, Özkan E.
Biorxiv 2024.07.08.602367 (2024). (* equal contribution)
Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development.
Carmona-Rosas G*, Li J*, Smith JJ*, Cheng S, Baltrusaitis E, Nawrocka WI, Zhao M, Kratsios P, Araç D, Özkan E.
Biorxiv 2023.05.04.539414 (2023). (* equal contribution)
WFIKKN2 is a bifunctional axon guidance cue that signals through divergent DCC family receptors.
Nickerson KR, Tom I, Cortés E, Abolafia JR, Özkan E, Gonzalez LC, Jaworski A.
Biorxiv 2023.06.15.544950 (2023).
2014-2024
Structural insights into the formation of repulsive Netrin guidance complexes.
Priest JM, Nichols EL, Smock RG, Hopkins JB, Mendoza JL, Meijers R, Shen K, Özkan E.
Sci. Adv. 10, eadj8083 (2024).
Neuronal wiring receptors Dprs and DIPs are GPI anchored and this modification contributes to their cell surface organization.
Lobb-Rabe M*, Nawrocka WI*, Zhang R, Ashley J, Carrillo RA†, Özkan E†.
eNeuro 11, ENEURO.0184-23.2023 (2024). (* equal contribution, † corresponding authors)
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis.
Wong S, Tan YX, Loh AYT, Tan KY, Lee H, Aziz Z, Nelson SF, Özkan E, Kayserili H, Escande-Beillard N, Reversade B.
EMBO Mol. Med. 15, e17078 (2023).
Endocytosis in the axon initial segment maintains neuronal polarity.
Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K.
Nature 609, 128–135 (2022).
Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel Receptors.
Wang J*, Vaddadi N*, Pak JS*, Park Y, Quilez S, Roman CA, Dumontier E, Thornton JW, Cloutier JF†, Özkan E†.
Cell Rep. 37, 109940 (2021). (* equal contribution, † corresponding authors)
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
Pak JS*, DeLoughery ZJ*, Wang J, Acharya N, Park Y, Jaworski A†, Özkan E†.
Nat. Commun. 11, 1489 (2020). (* equal contribution, † corresponding authors)
Finally on track: Interactions of Off-Track with Plex-Sema pathway and glycosaminoglycans.
Cheng S, Özkan E.
Structure 28, 492 (2020).
Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
Cheng S*, Park Y*, Kurleto JD*, Jeon M, Zinn K, Thornton JW, Özkan E.
Proc. Natl. Acad. Sci. U. S. A. 116, 9837 (2019). (* equal contribution)
Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.
Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Özkan E.
eLife 8, e41028 (2019).
Planar-polarized Semaphorin-5c and Plexin A promote the collective migration of epithelial cells in Drosophila.
Stedden CG, Menegas W, Zajac AL, Williams AM, Cheng S, Özkan E, Horne-Badovinac S.
Curr. Biol. 29, 908 (2019).
A proteomic screen of neuronal cell-surface molecules reveals IgLONs as structurally conserved interaction modules at the synapse.
Ranaivoson FM, Turk LS, Ozgul S, Kakehi S, von Daake S, Lopez N, Trobiani L, De Jaco A, Denissova N, Demeler B, Özkan E, Montelione GT, Comoletti D.
Structure 27, 893 (2019).
Neural immunoglobulin superfamily interaction networks.
Zinn K, Özkan E.
Curr. Opin. Neurobiol. 45, 99 (2017).
Deconstruction of the Beaten Path-Sidestep interaction network provides insights into neuromuscular system development.
Li H, Watson A, Olechwier A, Anaya M, Sorooshyari SK, Harnett DP, Lee HKP, Vielmetter J, Fares MA, Garcia KC, Özkan E, Labrador JP, Zinn K.
eLife 6, e28111 (2017).
Interview: Journey into the heart of the Purkinje cell synapse.
Kostic M.
Cell Press (2017).
Conformational plasticity in the transsynaptic Neurexin-Cerebellin-Glutamate Receptor adhesion complex.
Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E.
Structure 24, 2163 (2016).
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
Dong X, Chiu H, Park YJ, Zou W, Zou Y, Özkan E, Chang C, Shen K.
eLife 5, e11008 (2016).
Control of synaptic connectivity by an interacting network of Drosophila IgSF cell surface proteins.
Carrillo RA*, Özkan E*†, Menon K*, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K†.
Cell 163, 1770 (2015). (* equal contribution, † corresponding authors)
MADD-4/Punctin and Neurexin organize C. elegans GABAergic postsynapses through Neuroligin.
Maro GS, Gao S, Olechwier AM, Hung WL, Liu M, Özkan E, Zhen M, Shen K.
Neuron 86, 1420 (2015).
“Velcro” engineering of high affinity CD47 ectodomain as Signal Regulatory Protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis.
Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman LI, Garcia KC.
J. Biol. Chem. 290, 12650 (2015).
Structure of an intermediate conformer of the Spindle Checkpoint protein Mad2.
Hara M*, Özkan E*, Sun H, Yu H, Luo X.
Proc. Natl. Acad. Sci. U. S. A. 112, 11252 (2015). (* equal contribution)
2006-2014
Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.
Özkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC.
Cell 156, 482 (2014). (See the cover on the right sidebar.)
Deconstructing the peptide-MHC specificity of T cell recognition.
Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Özkan E, Davis MM, Wucherpfennig KW, Garcia KC.
Cell 157, 1073 (2014).
An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks.
Özkan E, Carrillo RA, Eastman CL, Weiszmann R, Waghray D, Johnson KG, Zinn K, Celniker SE, Garcia KC.
Cell 154, 228 (2013).
Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.
Weiskopf, K, Ring AM, Ho CCM, Levin AM, Volkmer J-P, Volkmer AK, Özkan E, van de Rijn M, Weissman IL, Garcia KC.
Science 341, 88 (2013).
Plum, an Immunoglobulin Superfamily protein, regulates axon pruning by facilitating TGF-β signaling.
Yu XM, Gutman I, Mosca TJ, Iram T, Özkan E, Garcia KC, Luo L, Schuldiner O.
Neuron 78, 456 (2013).
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande V, Li P, Moraga I, Spolski R, Özkan E, Leonard WJ, Garcia KC.
Nat. Immunol. 13, 1187 (2012).
Molecular and structural insight into proNGF engagement of p75NTR and sortilin.
Feng D, Kim T, Özkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC.
J. Mol. Biol. 396, 967 (2010).
Gabapentin receptor α2δ-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
Eroglu C, Allen NJ, Susman MW, O’Rourke NA, Park CY, Özkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA.
Cell 139, 380 (2009).
Structures of neuroligin-1 and the neuroligin-1/neurexin-1β complex reveal specific protein-protein and protein-Ca2+ interactions.
Araç D, Boucard AA, Özkan E, Strop P, Newell E, Südhof TC, Brunger AT.
Neuron 56, 992 (2007).
Before 2006
Mechanistic insight into the allosteric activation of a Ubiquitin-conjugating enzyme by RING-type Ubiquitin ligases.
Özkan E, Yu H, Deisenhofer J.
Proc. Natl. Acad. Sci. U. S. A. 102, 18890 (2005).
APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.
Tang Z, Li B, Bharadwaj R, Zhu H, Özkan E, Hakala K, Deisenhofer J, Yu H.
Mol. Biol. Cell 12, 3839 (2001).
The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain.
Usher KC, Özkan E, Gardner KH, Deisenhofer J.
Proc. Natl. Acad. Sci. U. S. A. 98, 10676 (2001).
See PubMed for full publication list, or visit Engin’s Google Scholar page.
