Publications

1. Contreras, GF, Sheng R, Latorre, R, and Perozo E. Structural Basis of Voltage-Dependent Gating in BK Channels. Nature Comms. 2025; In press

2. Lin X, Haller P, Bavi N, Faruk N, Perozo E, Sosnick TR. Folding of Prestin’s Anion-Binding Site and the Mechanism of Outer Hair Cell Electromotility. eLife. 2023;12:RP89635.  https://doi.org/10.7554/eLife.89635.3 

3. Bavi N, Clark MD, Contreras GF, Shen R, Reddy BG, Milewski W, Perozo E. Prestin’s Conformational Cycle Underlies Outer Hair Cell Electromotility Nature. 2021;600(7889):553-558. http://doi.org/10.1038/s41586-021-04152-4 

4. Clark MD, Contreras GF, Sheng R and Perozo E. Electromechanical coupling in the hyperpolarization-activated K + channel KAT1. Nature. 2020;583(7814):145-149. http://doi.org/10.1038/s41586-020-2335-4 

5. Reddy, B, Bavi, N, Lu, A, Park, Y, Thornton, JW, Perozo, E. Structure of MscS in a lipid bilayer and the Mechanism of Force-from-Lipid Mechanotransduction. eLife, 2019;doi: 10.7554/eLife.50486. http://doi.org/10.7554/eLife.50486 

6. Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, et al. Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating. Cell. 2016;164(4):747–56. http://doi.org/10.1016/j.cell.2015.12.055 

7. Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E. Resting state of the human proton channel dimer in a lipid bilayer. Proc Natl Acad Sci U S A. 2015;112(44):E5926-35. http://doi.org/10.1073/pnas.1515043112 

8. Li Q, Sherry Wanderling, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea C, Hulse RE, Roux B, Schulten K, Kossiakoff A and Perozo E. Structural Mechanism of Voltage-Dependent Gating in an Isolated Voltage-Sensing Domain. Nature Structural & Molecular Biology, 2014; 21(3):244-52. http://doi.org/10.1038/nsmb.2768 

9. Dalmas O, Sompornpisut T., and Perozo E. Mg2+-dependent gating of CorA and its open channel conformation. Nature Comms. 2014;5:3590. https://doi.org/10.1038/ncomms4590 

10. Li Q, Wanderling S, Sompornpisut P, Perozo E. Structural Basis of Lipid-Driven Conformational Transitions in the KvAP Voltage Sensing Domain. Nature Structural & Molecular Biology. 2014;21(2):160-166. http://doi.org/10.1038/nsmb.2747 

11. Uysal, S., Cuello, LG., Cortes, DM., Koide, S., Kossiakoff, A., and Perozo, E. Mechanism of Activation Gating in the Full-Length KcsA K+ Channel. Proc. Natl. Acad. Sci. USA. 2011; 108(29):11896-11899. http://doi.org/10.1073/pnas.1105112108 

12. Cuello, LG, Cordero-Morales, J., Jogini, V., Perozo, E. Structural basis for the coupling between activation and inactivation gates in K+ channels. Nature. 2010; 466:272-275. http://doi.org/10.1038/nature09136 

13. Cuello, LG, Jogini, V., Cortes, DM, Perozo, E. Structural mechanism of C-type inactivation in K+ channels. Nature. 2010; 466:203-208. http://doi.org/10.1038/nature09153 

14. Vásquez, V., Sotomayor, M., Cordero-Morales, J., Schulten, K., and Perozo E. (2008) A Structural Mechanism for MscS Gating in Lipid Bilayers. Science, 321:1210-4. http://doi.org/10.1126/science.1159674 

15. Cordero-Morales, JF., Jogini, V., Lewis, A., Vásquez, V., Cortes, D.M., Roux, B., and Perozo, E. Molecular Driving Forces Determining Potassium Channel Slow Inactivation. Nature Structural & Molecular Biology, 2007;14:1062-1069. http://doi.org/10.1038/nsmb1309 

16. Cuello, L.G. Cortes DM and Perozo, E. Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science. 2004;306:491-495. http://doi.org/10.1126/science.1101373 

17. Perozo, E., Cortes, DM, Sompornpisut,P., Kloda, A., and Martinac, B. Structure of MscL in the open state and the molecular mechanism of gating in mechanosensitive channels. Nature 2002;418 (6901):942-8. http://doi.org/10.1038/nature00992 

18. Perozo, E., Kloda, A., Cortes, DM, and Martinac, B. Nature. 2002; Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Structural Biology 9:696-703. https://doi.org/10.1038/nsb827  

19. Perozo, E., Cortes, D.M., and Cuello, L.G. Structural Rearrangements Underlying K+ Channel Activation Gating.  Science. 1999; 285(5424): 73-78. http://doi.org/10.1126/science.285.5424.73 

20. Perozo, E., Cortes, D.M., and Cuello, L.G. Three-Dimensional Architecture of a K+ Channel: Implications for the mechanism of ion channel gating. Nature Structural Biology. 1998; 5(6):457-467. http://doi.org/10.1038/nsb0698-459