The Rice Lab

How do mobile genetic elements jump? How does DNA get rearranged?   What are the biological consequences?  How can we make recombinases even more useful? We use biochemistry, structural biology, and microbiology to get mechanistic answers.

SCCmec: the mysterious mobile element behind the MRSA epidemic

Serine recombinases large and small: molecular swivels that are useful in synthetic biology and genome engineering

Mu transpsosome: the paradigmatic jumping gene machine