by dankrochmal | Jun 30, 2022 | News, Publication
Structural Basis for Fluorescence Activation by Pepper RNA Pepper is a fluorogenic RNA aptamer tag that binds to a variety of benzylidene-cyanophenyl (HBC) derivatives with tight affinity and activates their fluorescence. To investigate how Pepper RNA folds to create...
by dankrochmal | Feb 11, 2022 | News, Publication
In January 2022 our group published a new paper in Nature Chemical Biology, where we describe a first crystal structure of a self-alkylating ribozyme along with some insights on the mechanism of reaction. Structural basis for substrate binding and catalysis by a...
by hcrees | Sep 14, 2021 | Publication
The programmed −1 ribosomal frameshifting element (PFSE) of SARS-CoV-2 is a well-conserved structured RNA found in all coronaviruses’ genomes. By adopting a pseudoknot structure in the presence of the ribosome, the PFSE promotes a ribosomal frameshifting event near...
by hcrees | Aug 9, 2019 | News, Publication
https://www.nature.com/articles/s41467-019-11585-z Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crystal...
