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Klawon, D.E.J., Gilmore, D.C., Leonard, J.D., Miller, C.H., Chao, J.L., Walker, M.T., Duncombe, R.K., Tung, K.S., Adams, E.J., and Savage, P.A. (2021). Altered selection on a single self-ligand promotes susceptibility to organ-specific T cell infiltration. https://doi.org/10.1084/jem.20200701
Miller, C.H., Klawon, D.E.J., Zeng, S., Lee, V., Socci, N.D., and Savage, P.A. (2020). Eomes identifies thymic precursors of memory-phenotype CD8+ T cells. Nature Immunology. https://doi.org/10.1038/s41590-020-0653-1 https://rdcu.be/b3xKt
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MacNabb, B.W., Kline, D.E., Albright, A.R., Chen, X., Leventhal, D.S., Savage, P.A., and Kline, J. (2019). Negligible role for deletion mediated by cDC1 in CD8+ T cell tolerance. Journal of Immunology, 202, 2628-2635.
Nalle, S.C., Zuo, L., Ong, M.L.D.M., Singh, G., Worthylake, A.M., Choi, W., Manresa, M.C., Southworth, A.P., Edelblum, K.L., Baker, G.J., Joseph, N.E., Savage, P.A., and Turner, J.R.* (2019). Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability. Journal of Clinical Investigation, 129, 902-914.
Chao, J.L. and Savage, P.A. (2018). Unlocking the complexities of tumor-associated regulatory T cells. Journal of Immunology, 200, 415-421.
Leonard, J.D., Gilmore, D.C., Dileepan, T., Nawrocka, W.I., Chao, J.L., Schoenbach, M.H., Jenkins, M.K., Adams, E.J., and Savage, P.A. (2017). Identification of natural regulatory T cell epitopes reveals convergence on a dominant autoantigen. Immunity, 47, 107-117, http//dx.doi.org/10.1016/j.immuni.2017.06.015.
Malchow, S., Leventhal, D.S., Lee, V., Nishi, S., Socci, N.D., and Savage, P.A. (2016). Aire enforces immune tolerance by directing autoreactive T cells into the regulatory T cell lineage. Immunity, 44, 1102-1113.
Leventhal, D.S., Gilmore, D.C., Berger, J., Nishi, S., Malchow, S., Kline, D.E., Kline, J., Vander Griend, D.J., Huang, H., Socci, N.D., and Savage, P.A. (2016). Dendritic cells coordinate the development and homeostasis of organ-specific regulatory T cells. Immunity 44, 847-859.
Lee, V., and Savage, P.A. (2015). Close encounters of the tertiary kind. Immunity 43, 418-420.
Kreymborg, K., Haak, S., Murali, R., Wei, J., Waitz, R., Gasteiger, G., Savage, P.A., van den Brink, M.R., and Allison, J.P. (2015). Ablation of B7-H3 but not B7-H4 results in highly increased tumor burden in a murine model of spontaneous prostate cancer. Cancer Immunology Research 3:849-854.
Chen, X., Fosco, D., Kline, D.E., Meng, L., Nishi, S., Savage, P.A., and Kline, J. (2014). PD-1 regulates extrathymic regulatory T-cell differentiation. European Journal of Immunology, 44: 2603–2616.
Nalle, S.C., Kwak, A., Edelblum, K.L., Joseph, N.E., Singh, G., Khramtsova, G.F., Mortenson, E.D., Savage, P.A.*, and Turner, J.R.* (2014). Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease. Science Translational Medicine, 6:243ra87. * Denotes co-corresponding authors.
Savage, P.A. (2014). Tumor antigenicity revealed. Trends in Immunology 35, 47-48.
Savage, P.A., Malchow, S., and Leventhal, D.S. (2013). Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors. OncoImmunology 2:e24898.
Malchow, S., Leventhal, D.S., Nishi, S., Fischer, B.I., Shen, L., Paner, G.P., Amit, A.S., Kang, C., Geddes, J.E., Allison, J.P., Socci, N.D., and Savage, P.A. (2013). Aire-dependent thymic development of tumor-associated regulatory T cells. Science, 339, 1219-1224.
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Savage, P.A., Malchow, S., Leventhal, D.S. (2013). Basic principles of tumor-associated regulatory T cells. Trends In Immunology, 34. 33-40.
Donkor, M.K., Sarkar, A., Savage, P.A., Franklin, R.A., Johnson, L.K., Jungbluth, A.A., Allison, J.P., and Li, M.O. (2011). Cell-autonomous TGF-b signaling suppresses T cell surveillance of tumor development. Immunity 35, 123-134.
Savage, P.A., Vosseller, K., Kang, C., Larimore, K., Riedel, E., Wojnoonski, K., Jungbluth, A.A., and Allison, J.P. (2008). Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes. Science 319, 215-220.
Savage, P.A. and Davis, M.M. (2001). A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity 14, 243-252.
Lee, P.P., Yee, C., Savage, P.A., Fong, L., Brockstedt, D., Weber, J.S., Johnson, D., Swetter, S., Thompson, J., Greenberg, P.D., Roederer, M., and Davis, M.M. (1999). Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nature Medicine 5, 677-685.
Savage, P.A., Boniface, J.J., and Davis, M.M. (1999). A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10, 485-492.
Yee, C., Savage, P.A., Lee, P.P., Davis, M.M., and Greenberg, P.D. (1999). Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. Journal of Immunology 162, 2227-2234.