Sisodia's Lab publications

Lab Publications

* Minter MR, Hinterleitner R, Meisel M, Zhang C, Leone V, Zhang X, Oyler-Castrillo P, Zhang X, Musch MW, Shen X, Jabri B, Chang EB, Tanzi RE, Sisodia SS (2017). Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease. 2017 Sep 5;7(1):10411.

* Minter MR, Zhang C, Leone V, Ringus DL, Zhang X, Oyler-Castrillo P, Musch MW, Liao F, Ward JF, Holtzman DM, Chang EB, Tanzi RE, Sisodia SS (2016) Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease. Sci Rep. 6:30028

* Sisodia SS: ß-amyloid precursor protein cleavage by a membrane-bound protease. Proc. Natl. Acad. Sci. USA 89: 6075-6079, 1992.
* Sisodia SS, Koo EH, Hoffman PN, Perry G and Price DL: Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13: 3136-3142, 1993.
* Buxbaum JD, Thinakaran G, Koliatsos V, O’Callahan J, Slunt HH, Price DL and Sisodia SS: Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J. Neurosci. 18:9629-9637, 1998.
* Orly Lazarov, Michael Lee, Daniel A. Peterson and Sangram S. Sisodia (2002). Evidence that Synaptically Released A Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice. J. Neurosci, 15:9785-93

* Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada C-M, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, Copeland NG, Jenkins NA, Price DL, Younkin SG and Sisodia SS: Familial Alzheimer’s disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17: 1005-1013, 1996.
*  von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, Van der Ploeg LHT, Price DL and Sisodia SS: Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol. Aging 18: 661-669, 1997.
* Lazarov O, Pigino G, Morfini GA, Gadadhar A, Chen X, Robinson J, Ho H,Brady ST, Sisodia SS (2007) Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing FAD-Linked mutant PS1. J. Neuroscience, 27: 7011-7020.

* Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitski T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins N, Copeland N, Price DL and Sisodia SS: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17: 181-190, 1996.
* Wong PC, Zheng H, Chen H, Becher MW, Sirinathsinghji DJS, Trumbauer ME, Chen HY, Price DL, Van der Ploeg LHT and Sisodia SS: Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature 387: 288-292, 1997.
* Borchelt DR, Ratovitski T, Van Lare J, Lee MK, Gonzales VB, Jenkins NA, Copeland NG, Price DL and Sisodia SS: Accelerated amyloid deposition in the brains of transgenic mice co-expressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19: 939-945, 1997.
* Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li Y, Koide S and Sisodia SS (2012) Identification of a TPR-like domain in the Nicastrin subunit of -secretase using synthetic antibodies. Proc. Natl. Acad. Sci. USA, 109:8534-9

* Orly Lazarov, John Robinson, Ya-Ping Tang, Ilana S. Hairston, Zeljka Korade-Mirnics, Virginia M.-Y. Lee, Lou B. Hersh, Robert M. Sapolsky, Karoly Mirnics and Sangram S. Sisodia (2005) “Environmental Enrichment Reduces A Levels and Amyloid Deposition in Transgenic Mice” Cell, 120, 701-713
* Choi S, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM and Sisodia SS (2008) Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation. Neuron, 59, 568-580
* Veeraraghavalu K. and Sisodia SS (2013) Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells. Proc. Natl. Acad. Sci USA, 110:9148-53
* Veeraraghavalu K, Zhang C, Zhang X, Tanzi RE, and Sisodia SS (2014) Age-dependent, non-cell autonomous deposition of amyloid from synthesis of Aβ by cells other than excitatory neurons. J. Neuroscience, 34:3668-73

Complete List of Published Work