The long-term goal of my laboratory is to decipher the etiology and pathogenesis of multiple sclerosis (MS) – a CNS demyelinating and neurodegenerative disease that cripples the young and bright. With the firm belief that in order to decrypt the breakdown of myelin in MS, we have to understand how it is formed, we began by developing an in vitro model to study the biology of oligodendrocytes (OLGs) – the cells that assemble the CNS myelin sheath.

• Long-term Oligodendrocyte Cultures: an In Vitro Model to Study their Biology
• Importance of the Nature of Substratum: Discovery of GRASP
• The Non-myelinating Phenotype of Oligodendrocytes
• Synthesis of Myelin Membranes and Assembly of the Myelin Sheath
• The Modular Architecture of the Myelinated Axon
• Actively Ongoing Research
• Selected References
• List of publications in Pubmed