Publications
Independent Career @ UChicago
8. Yan H, Tan E, Zou S, Sun Y, Ke A*, Tang W*, Assessing and engineering the IscB-ωRNA system for programmed genome editing. Nat. Chem. Biol. 2024, https://doi.org/10.1038/s41589-024-01669-3.
![IscB_TOC](https://voices.uchicago.edu/tanglab/files/2024/08/IscB_TOC-scaled.jpg)
7. Yan H, Tang W*, Programmed RNA Editing with an Evolved Bacterial Adenosine Deaminase. Nat. Chem. Biol. 2024, https://doi.org/10.1038/s41589-024-01661-x.
![TOC_final_DECOR](https://voices.uchicago.edu/tanglab/files/2024/07/TOC_final_DECOR-scaled.jpg)
6. Ge R, He ME, Tang W*, N6-Methyladenosine in Mammalian Messenger RNA: Function, Location, and Quantitation. Isr. J. Chem. 2024, https://doi.org/10.1002/ijch.202300181.
![m6A review abstract](https://voices.uchicago.edu/tanglab/files/2024/04/m6A-review-abstract-0d89ca52adab82f1-e1713216317526.jpg)
5. Xiao Y#, Chen Y-M#, Zou Z, Ye C, Dou X, Wu J, Liu C, Liu S, Yan H, Wang P, Zeng T-B, Liu Q, Fei J, Tang W, He C*, Profiling of RNA-Binding Protein Binding Sites by In Situ Reverse Transcription-Based Sequencing. Nat. Methods. 2024, https://doi.org/10.1038/s41592-023-02146-w.
4. Xiao YL, Wu Y, Tang W*, An Adenine Base Editor Variant Expands Context Compatibility. Nat. Biotechnol. 2024, https://doi.org/10.1038/s41587-023-01994-3.
Addgene link for E. coli and mammalian expression plasmids: https://www.addgene.org/browse/article/28238713/
Research Highlight: Tang L, More Deaminases Towards Precise Editing. Nat. Methods. 2024, https://doi.org/10.1038/s41592-024-02193-x.
![toc of ABE8r paper (1)](https://voices.uchicago.edu/tanglab/files/2023/09/toc-of-ABE8r-paper-1.png)
3. Wu T#, Liu C#, Zou S#, Lyu R, Yang B, Yan H, Zhao M*, Tang W*, An Engineered Hypercompact CRISPR-Cas12f System with Boosted Gene-Editing Activity. Nat. Chem. Biol. 2023, https://doi.org/10.1038/s41589-023-01380-9.
Addgene link for E. coli and mammalian expression plasmids: https://www.addgene.org/browse/article/28238262/
![Cas12f_GA_v3](https://voices.uchicago.edu/tanglab/files/2023/06/Cas12f_GA_v3.jpg)
2. Huang AT, Tang W*, Smoking-Related DNA Alkylation Events Are Mapped at Single-Nucleotide Resolution. News & Views. ACS Cent. Sci. 2023, 9, 346-348, https://doi.org/10.1021/acscentsci.3c00246.
![TOC](https://voices.uchicago.edu/tanglab/files/2023/03/TOC.jpg)
1. Xiao YL#, Liu S#, Ge R#, Wu Y, He C,* Chen M,* Tang W,* Transcriptome-wide Profiling and Quantification of N6-methyladenosine by Enzyme-Assisted Adenosine Deamination, Nat. Biotechnol. 2023, https://doi.org/10.1038/s41587-022-01587-6.
Addgene link for E. coli expression plasmid of TadA 8.20: https://www.addgene.org/194702/
![a](https://voices.uchicago.edu/tanglab/files/2023/01/m6a.jpg)
Post-doc Research @ Broad Institute
- Tang W, Liu DR*. Rewritable multi-event analog recording in bacterial and mammalian cells. Science 2018, 360, eaap8992
- Hu JH, Miller SM, Geurts MH, Tang W, Chen L, Sun N, Zeina C, Gao X, Rees HA, Lin Z, Liu DR*. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity. Nature 2018, 556, 57–63
- Tang W, Hu JH, Liu DR*. Aptazyme-embedded guide RNAs enable ligand-responsive genome engineering. Nat. Commun. 2017, 8, 15939
Ph.D. Research @ Illinois
- Rahman IR, Sanchez A, Tang W, van der Donk WA*. Structure-activity relationships of the Enterococcal cytolysin. ACS Infect. Dis. 2021, 7, 2445-2454.
- Bobeica SC, Zhu L, Acedo JZ, Tang W, van der Donk WA*. Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways. Chem. Sci. 2020, 11, 12854-12870.
- Tang W, Bobeica SC, Wang L, van der Donk WA*. CylA is a sequence-specific protease involved in toxin biosynthesis. J. Ind. Microbiol. Biotechnol. 2019, 46, 537-549
- Tang W, Thibodeaux GN, van der Donk WA*. The enterococcal cytolysin synthetase coevolves with substrate for stereoselective lanthionine synthesis. ACS Chem. Biol. 2016, 11, 2438-2446
- Dong SH#, Tang W#, Lukk T, Nair SK*, van der Donk WA*. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. eLife 2015, 4, 07607 (# equal contribution)
- Tang W, Jiménez-Osés G, Houk KN*, van der Donk WA*. Substrate control in stereoselective lanthionine biosynthesis. Nat. Chem. 2015, 7, 57-64
- Tang W#, Dong SH#, Repka LM, He C, Nair SK*, van der Donk WA*. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chem. Sci. 2015, 6, 6270-6279 (# equal contribution)
- Tang W, van der Donk WA*. The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry. Nat. Chem. Biol. 2013, 9, 157-159
- Tang W, van der Donk WA*. Structural characterization of four prochlorosins: a novel class of lantipeptides produced by planktonic marine cyanobacteria. Biochemistry 2012, 51, 4271-4279