Publications

For an up to date bibliography of the Mendoza group, follow the link to:
NCBI: https://www.ncbi.nlm.nih.gov/myncbi/1VIKilybX2jQz/bibliography/public/
Google Scholar: https://scholar.google.com/citations?user=mvw5excAAAAJ&hl=en
LinkedIn: https://www.linkedin.com/in/juan-l-mendoza-phd/
Twitter: https://twitter.com/DrJuanLMendoza

Featured Publications

  1. Grubbe, W.S., Bylehn, F., Alvarado, W., de Pablo, J.J., and Mendoza, J. L.. “Molecular analysis of the type III interferon complex and its applications in protein engineering.” Biophysical Journal (2023). [DOI]
  2. Aung, T., Horvath, C.M., and Mendoza, J. L.. “Enhanced Complex Stability and Optimal JAK Geometry are Pivotal for a Potent Type III Interferon Response.” bioRxiv (2022). [bioRxiv]
  3. Mansurov, A., Hosseinchi, P., Chang, K.,…, Mendoza, J. L., Ishihara, J., and Hubbell, J.A.. “Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.” Nat Biomed Eng (2022). [PubMed]
  4. Onabajo, O.O., Banday, A.R., Yan, W., Obajemu, A., Stanifer, M.L., Santer, D.M., Florez-Vargas, O., Piontkivska, H., Vargas, J., Kee, C., Tyrrell, D.L.J., Mendoza, J.L., Boulant, S., and Prokunina-Olsson, L.. “Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2.” Nature Genetics (2020). [PubMed]
  5. Mendoza, J.L., *Escalante, N.K., *Jude, K.M., *Sotolongo Bellon, J., Su, L., Horton, T.M., Tsutsumi, N., Berardinelli, S.J., Haltiwanger, R.S., Piehler, J., Engleman, E.G., and Garcia, K.C. “Structure of the IFNγ receptor complex guides design of biased agonists.” Nature (2019). * Denotes an equal contribution. [Nature]
    Featured In: Faculty of 1000
  6. Mendoza, J.L., Fischer, S., Gee, M.H., Brackenridge, S., Powrie, F.M., Birnbaum, M., McMichael, A.J., Garcia, K.C, and Gillespie, G.M.. “Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity.” eLife (2020). [eLife]
  7. Mendoza, J.L., *Escalante, N.K., *Jude, K.M., *Sotolongo Bellon, J., Su, L., Horton, T.M., Tsutsumi, N., Berardinelli, S.J., Haltiwanger, R.S., Piehler, J., Engleman, E.G., and Garcia, K.C. “Structure of the IFNγ receptor complex guides design of biased agonists.” Nature (2019). * Denotes an equal contribution. [Nature]
    Featured In: Faculty of 1000
  8. Gee, M.H., Han, A., Lofgren, S.M., Beausang, J.F., Mendoza, J.L., Birnbaum, M.E., Bethune, M.T., Fischer, S., Yang, X., Gomez-Eerland, R., Bingham, D.B., Sibener, L.V., Fernandes, R.A., Velasco, A., Baltimore, D., Schumacher, T.N., Khatri, P., Quake, S.R., Davis, M.M., and Garcia, K.C. “Antigen identification for orphan T cell receptors expressed on tumor-infiltrating lymphocytes.” Cell 172 (2018), 549-563. [PubMed]
  9. *Moraga, I.M., *Spangler, J.B., *Mendoza, J.L., J.B., Gakovic, M., Wehrman, T.S., Krutzik, P., Garcia, K.C. “Synthethic cytokines dimerizing novel cytokine receptor pairs elicit new signaling programs and immune activities.” eLife 6 (2017), e22882. * Denotes an equal contribution. [PubMed]
  10. Mendoza, J.L., Schneider, W., Hans-Heinrich, H., Vercauteren, K., Jude, K.M., Xiong, A., Moraga, I., Horton, T., Glenn, J.S., de Jong, Y., Rice, C.M., Garcia, K.C. “The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.” Immunity 46 (2017), 379-392. [PubMed] 
    Featured on the Cover 
  11. Birnbaum, M.E., Mendoza, J.L., Sethi, D.K., Dong, S., Glanville, J., Dobbins, J., Ozkan, E., Davis, M.M., Wucherpfennig, K.W., and Garcia, K.C. “Deconstructing the peptide-MHC specificity of T cell recognition.” Cell 157 (2014), 1073–1087. [PubMed]
  12. Mendoza, J.L., Schmidt, A., Li, Q., Caspa, E., Barrett, T., Brautigam, C.A., Bridges, R.J., Feranchak, A.P., and Thomas, P.J. “Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences.” Cell 148 (2012), 164-174. [PubMed]