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Brian’s new paper: experimental evolution of ancestral proteins

Our new paper on experimental evolution of reconstructed ancestral proteins: Historical contingency is the dominant factor in evolution of protein sequence variation, even under strong selection. Out today in @eLife. 1/ https://t.co/AiPd4Jga9s — JoeThornton (@JoeThorntonLab) June 4, 2021

Congratulations to Santi: American Society of Naturalists Award!

Congratulations to Santiago Herrera Alvarez, who has received this year’s Student Research Award from ASN.  The award recognizes outstanding graduate students whose research advances “the conceptual unification of ecology, evolution, or behavior.”  How awesome that Santi’s work on protein evolution is… Continue Reading →

Georg’s paper on entrenchment of useless protein complexes

Our work on a simple mechanism -- an evolutionary biochemical ratchet -- that causes useless protein complexes to persist over very long timescales.

Our work on a simple mechanism — an evolutionary biochemical ratchet — that causes useless protein complexes to persist over very long timescales. Our new paper on the evolutionary persistence of useless molecular complexes, out today in @nature. 1/6 https://t.co/Z3OZDKzBDE… Continue Reading →

Arvind’s paper on hemoglobin evolution

Congratulations to Arvind for his incredible paper on the evolution of hemoglobin, published in Nature.  

Congratulations to Arvind for his incredible paper on the evolution of hemoglobin, published in Nature. Our new paper on the evolutionary origins of hemoglobin, out today in @nature. A heroic body of work by @ArvindSPillai1, with indispensable contributions by @KaHochberg,… Continue Reading →

Qinwen’s new paper using “ancestralized” transgenic flies for evo-devo

eLife published our paper, “Ancient mechanisms for the evolution of the bicoid homeodomain’s function in fly development.” The paper marks the first time that transgenic animals carrying reconstructed ancestral proteins have been used to study the evolution of development. This… Continue Reading →

Aarti’s paper on rampant errors in selection tests because of multinucleotide mutations

Nature Ecology and Evolution published our paper, “Multinucleotide mutations cause false inferences of lineage-specific positive selection.” The work was part of Aarti Venkat’s thesis, and it was especially fun to work with coauthor Matt Hahn, an expert in MNMs at… Continue Reading →

Congratulations Dr. Starr and Dr. Venkat!

In the last two months, Tyler and Aarti successfully defended the beautiful work in their dissertations. Dr. Tyler will soon start a postdoc with Jesse Bloom and Erick Matsen at the Fred Hutch in Seattle, and Dr. Aarti is a… Continue Reading →

New paper in PNAS on contingency and entrenchment

PNAS has just published our paper, “Pervasive contingency and entrenchment in a billion years of Hsp90 evolution.”  It’s the product of a great collaboration with Dan Bolon’s lab, and our graduate student Tyler Starr is a co-first author. Here are… Continue Reading →

Our new paper in Nature on alternative protein histories

Today Nature published graduate student Tyler Starr’s magnum opus*, Alternative evolutionary histories in the sequence space of an ancient protein.  The paper reports on the first application of deep mutational scanning to a reconstructed ancestral protein.  This approach allowed us to compare the… Continue Reading →

Testing adaptation using “ancestralized” transgenic animals

Nature Ecology and Evolution published our paper, “Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster.” Led by graduate student Mo Siddiq, the paper reports on the first experiments on transgenic animals carrying reconstructed ancestral genes.  Mo used this… Continue Reading →

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