Memories of places and events associated with where drugs of abuse are consumed can trigger cravings and relapse even after years of abstinence. My research aims at understanding the neural mechanisms that are involved in forming these memories and how they are influenced by the actions of different neuromodulators. I study this using mouse models, innovative behavior paradigms and record from dendrites, axons and thousands of neurons in the hippocampus with two-photon microscopy to develop a network level understanding of why drug-related memories are so strong.