Evaluation of the Potential to use Histotripsy for Sonochemical Reactions

Conversion of terephthalate acid (TA) to hydroxylxerephtalate acid (HTA) via ROS formation quantified with spectrofluorometric assay. Light emissions were recorded with a photomultiplier tube (PMT). Bubble cloud activity was assessed with passive cavitation imaging (PCI).

 

 

 

 

 

 

 

 

 

  • Production of ROS during Histotripsy Insonation
  • The total ROS production was an order of magnitude lower than previous studies4, but ROS production rate 25-fold greater
  • Future study of histotripsy-induced ROS include optimizing insonation parameters and combining histotripsy with sonosensitizers1
  • Utilizing histotripsy for cell lysis and the generation of toxic ROS levels is an innovative method to treat cancer.