Evaluation of the Potential to use Histotripsy for Sonochemical Reactions

Sonodynamic therapy (SDT) utilizes light emissions generated by inertial cavitation activity to generate reactive oxygen species. Bubble activity generated by histotripsy is highly inertial, and may be used for in situ activate of SDT particles. We have performed preliminary analysis of the capabilities of histotripsy bubble activity to generate reactive oxygen species:

• Generation of reactive oxygen species due to histotripsy insonation alone
• Histotripsy activation of SDT particles