Resource: The Integrated Small Animal Imaging Research Resource
What is the iSAIRR?
The Integrated Small Animal Imaging Research Resource (iSAIRR) is a synergistically integrated infrastructure that offers a broad spectrum of imaging modalities, techniques, and services for in vivo imaging of small animals and ex vivo imaging of tissue/organ specimens. Its goal is to provide University of Chicago investigators and external users with state of the art, quantitative multi-modality imaging technologies to advance in-vivo molecular and physiological research of a broad range of disease and cancer models, and to accelerate pre-clinical development of novel therapeutics and diagnostic tools. Currently, iSAIRR sub-cores feature magnetic resonance imaging and spectroscopy (MRIS); optical imaging (bioluminescence and fluorescence) (OICF); positron emission tomography, single photon emission computed tomography, and computed tomography (PET/SPECT/CT); and veterinary technology (IVT). iSAIRR comprehensive services include (1) assistance with experimental design, (2)assisted and/or independent image acquisition, (3) veterinary support for all imaging modalities, and (4) assistance with data processing and interpretation.
Website
Click here to visit the iSAIRR’s website.
Bioluminescence optical imaging of a mouse.
Chord-based ROI CT unit.
Fusion imaging of a mouse (CT and SPECT) demonstrating thyroid activity.
High-sensitivity table-top prototype PET system.
Super resolution SPECT microscope image of a mouse.
The microPET/SPECT/CT system operated by the iSAIRR.
MR image of a mouse demonstrating non-invasive intraductal cancer.
The pre-clinical in vivo optical imaging system operated by the OICF.
Leadership
Chin-Tu Chen, Ph.D. Faculty Co-Director, iSAIRR
Brian Roman, Ph.D. Faculty Co-Director, iSAIRR
Greg Karczmar, Ph.D. Faculty Director, MRIS
Patrick LaRiviere, Ph.D. Faculty Director, OICF
Chien-Min Kao, Ph.D. Faculty Director, microPET/SPECT/CT
George Langen, DVM Faculty Director, IVT
Lara Leoni, Ph.D. Technical Director, iSAIRR
Xiaobing Fan, Ph.D. Technical Director, MRIS
Jeffrey Souris, Ph.D. Technical Director, OICF
Hsiu-Ming Tsai, Ph.D. Technical Director, microPET/SPECT/CT
Marta Zamora, B.A./A.A.S. Technical Director, IVT