Research Articles
Hartmann S, Radochonski L, Ye C, Sobrido-Martinez L, Chen J. SARS-CoV-2 ORF3a drives dynamic dense body formation for optimal viral infectivity. Preprint (In Review). 2024 May.
In this study we discovered and characterized a novel type of membrane structures assembled during SARS-CoV-2 infection, which we named the 3a dense bodies (3DBs).
Chen J and Chen ZJ. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation. Nature. 2018 Dec. PMID: 30487600
- Research Highlight in Nature Reviews Immunology.
- Research Highlight in Cell Research.
- Recommendations on Faculty of 1000.
Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJ. Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation. Cell. 2014 Mar. PMID: 24630723
Liu S*, Chen J*, Cai X, Wu J, Chen X, Wu YT, Sun L, Chen ZJ. MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. eLife. 2013 Aug. PMID: 23951545 (*co-first authors)
Skaug B, Chen J, Du F, He J, Ma A, Chen ZJ. Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell. 2011 Nov. PMID: 22099304
Reviews
Mullins B and Chen J. NLRP9 in Innate Immunity and Inflammation. Immunology. 2020 Dec 6. PMID: 33283292
Tan X, Sun L, Chen J, Chen ZJ. Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids. Annu Rev Microbiol. 2018 Sep. PMID: 30200854
Chen J and Chen ZJ. Regulation of NF-κB by ubiquitination. Curr Opin Immunol. 2013 Feb. PMID: 23312890