Computational imaging from medical to microscopy

We develop algorithms and algorithm-enabled imaging systems at scales from nanometers (x-ray microscopy) to meters (human computed tomography). Themes that span all scales and modalities include dose reduction, material identification, and orientation imaging.



August 25, 2018: Zebrafish x-ray histology paper posted on BiorXiv

Our paper introducing x-ray histology producing cellular resolution across an entire organism has been posted on BiorXiv.


May 23, 2018: Dr. Patrick La Riviere selected as 2018

Distinguished Investigator awardee

Dr. Patrick La Riviere who has been selected as a 2018 Distinguished Investigator awardee by the Academy for Radiology & Biomedical Imaging Research. This honor recognizes individuals for their accomplishments in the field of medical imaging. Recipients of the Distinguished Investigator Award have attained a level of accomplishment that ranks within the top 10% of all academic radiology faculty.

Dr. Patrick LaRiviere selected as 2018 Distinguished Investigator awardee


Jan 11, 2018: Shark, Shark!

The La Riviere lab contributed to this study of an ancient shark:

Study of ancient fossil complicates the shark family tree


November, 2017: They did it all with mirrors.

Mirror paper published in Nature Communications. 

In collaboration with Hari Shroff at NIH, Dr. La Riviere and Corey Smith helped double the speed and collection efficiency of the diSPIM dual-view light microscope. This is accomplished by placing the sample on a mirror, which reflects both the light sheet and the emitted fluorescence. The imaging model becomes much more complicated than a simple convolution, but working with Yicong Wu in Hari’s lab, we developed a model and algorithm to handle it.

Not an Illusion: Clever Use of Mirrors Boosts Performance of Light-Sheet Microscope

Mirror image: Researchers create higher-quality pictures of biospecimens | National Institute of Biomedical Imaging and Bioengineering 


September, 2017: High-speed polarized fluorescence microscope paper published in PNAS

Our collaborator Shalin Mehta published a lovely paper using high-speed fluorescence anisotropy studies to  create rapid movies of oriented molecules in a live cell. We contributed mainly some analytical tools  here but this study has drawn us into this fascinating problem of molecular orientation imaging. There will be more nice papers along these lines in coming years.

New Microscope Developed at MBL Reveals Nanoscale Structural Dynamics in Live Cells


August, 2016: Triple-view light sheet paper is published in Optica

In collaboration with Hari Shroff at NIH, Dr. La Riviere and Corey Smith developed the algorithmic framework for modeling a triple-view extension of the dual-view light-sheet microscope. The main computational challenge was to model the effective PSF of the high-NA bottom view, which involves a moving acquisition synchronized with the camera rolling shutter, which is what allows it to image a titled light sheet in focus. The work was published in Optica.

Every Photon is Valuable: New Microscope Captures “Lost” Fluorescence, Improving Resolution


June, 2016: Patrick La Riviere named a fellow of the MBL

Dr. La Riviere was named an inaugural fellow of the MBL, in recognition of his ongoing collaborations there in computational microscopy.

Marine Biological Laboratory Announces First MBL Fellows