Welcome to the Prince lab, where we use cellular, molecular, genetic, genomic and comparative approaches to study developmental processes. Our research program primarily makes use of the zebrafish, Danio rerio, which provides rapidly developing, transparent embryos. These embryos are ideal for high resolution live imaging approaches, which are helping us to understand the dynamic cellular processes that build complex structures during embryonic development. Our imaging experiments are complemented by powerful molecular genetic and transgenic tools, such as CRISPR/Cas technology, which allow us to interrogate the molecular basis of developmental processes. In addition to zebrafish, Prince lab members use little skate and other species in comparative studies. Please take a look around our pages to learn more about our ongoing studies on the neural crest, the anterior lateral line, and the pronephros. 

Lab members standing in front of Culver Hall door

NEWS AND EVENTS

Ana Beiriger successfully defends her PhD thesis!

Ana Beiriger successfully defends her PhD thesis!


A huge congratulations to the Prince Lab’s newest PhD, Dr. Ana Beiriger. Her PhD thesis is titled “Origins and Migration of the Octavolateral Efferent and Facial Branchiomotor Neurons in Zebrafish”. Ana led the lab’s studies on resolving the developmental origins of the facial branchiomotor neurons and octavolateral Efferent neurons and their tangential migration through the zebrafish hindbrain. She also pioneered the use of high resolution lightsheet microscopy to rapidly image neuronal migration in the hindbrain, a technique that is now extensively used by most lab members. We’re very lucky to have Ana stay on in the lab after her defense to continue working on some research projects. For more on Ana’s research, check out the Research section and look out for her soon to be published paper in the Journal Of Comparative Neurology!

Prince lab paper makes cover of Developmental Dynamics!

Prince lab paper makes cover of Developmental Dynamics!

Developmental biology makes for beautiful ideas and beautiful images! A confocal microscopy image of a transgenic 18 hour post fertilization embryo showing migrating neural crest cells made the cover of the journal Developmental Dynamics for January 2020. The image is from the lab’s latest publication: Neural crest development: insights from the zebrafish by current lab members Manny Rocha, Anastasia Beiriger, Noor Singh, Vicky Prince, and former lab graduate student Kamil Ahsan. Check out the paper here: https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.122

Manny Rocha featured on NIH social media!

Manny Rocha featured on NIH social media!

Prince lab fifth year graduate student Manny Rocha was featured on the NIH’s instagram page. Manny, originally from Costa Rica, is a recipient of the prestigious F31 diversity training grant which provides for research work, attending conferences, and collaborations with other labs. Manny is currently working on the early development and patterning of neural crest cells along the head-trunk axis.

 

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Meet Manny Rocha, a graduate student in the lab of Dr. Victoria Prince at the University of Chicago. Manny’s research is supported by our F31 diversity training grant, which enables him to attend scientific conferences, form research collaborations, and even train in other labs. Manny, originally from Costa Rica, studies neural crest cells, a temporary cell that exists during embryonic development. Using zebrafish as a model, Manny investigates how neural crest cells develop into two distinct types that are responsible for forming the head and the trunk of the body. When problems arise in this early development, diseases called neurocristopathies can occur. These include cleft palate, Waardenburg syndrome, and Hirschsprung disease. Swipe to see more photos of Manny conducting research in the lab, including a microscopy image that made it onto the cover of Developmental Dynamics (credit: Prince Lab at the University of Chicago, http://bit.ly/2Tr2smz, http://bit.ly/35X0rAY). @ucprincelab @uchicago @uchicagobsd #NICHD #NIH #Biology #EmbryonicDevelopment #Research #Lab #Science #Researcher #BirthDefects

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Zebrafish (Danio rerio) at 18 hours post fertilization. PC Ana Beiriger

Culver Hall, home of the Prince Lab

Developmental Biology Cover Image Rocha et al.

10.1016/j.ydbio.2021.08.002