September 12, 2023
Giorgia Giordano and Kate Shimamoto presented their translational ALL research at the University of Chicago Committee on Cancer Biology Trainee Scientific Symposium.

August 15, 2023
We identified LCK and ACK1 signaling pathways as drivers of T-ALL resistance to BCL-2 and BCL-xL inhibition, respectively. This paper lays the foundation for our phase 1b/2 study investigating the combination of LP-118 plus ponatinib in relapsed T-ALL.

August 2, 2023
Our Pritzker School of Medicine Experience in Research (PSOMER) student, Zachary Chen, presented his work on menin inhibition in ALL. We enjoyed working with Zach during his eight week summer rotation in the lab.

July 5, 2023
Clonal hematopoiesis of indeterminate potential (CHIP) is a multi-system syndrome and increases the risk for blood cancers, cardiovascular diseases, autoimmune disease, chronic kidney and liver diseases. As the scientific community recognizes its impact across medical disciplines, Dr. Caner Saygin started a multidisciplinary CHIP Clinic at the University of Chicago Comprehensive Cancer Center. This clinic serves to understand the factors associated with progression of CHIP, and bring new therapies for individuals with high-risk CHIP.

July 1, 2023
Dr. Caner Saygin and Dr. Wendy Stock received a $944,000 Leukemia Lymphoma Society (LLS) Academic Clinical Trials Award to translate their laboratory discoveries into a phase 1b/2 study targeting apoptotic and signaling pathways in relapsed T-ALL. The trial will accrue patients at multiple cancer centers nationwide.

May 3, 2023
Jen Cooperrider received the 2023 American Society of Hematology Research Training Award for Fellows. Jen is co-mentored by Dr. Andrzej Jakubowiak, and her work focuses on clonal hematopoiesis as a risk factor for therapy-related leukemia after treatment for multiple myeloma. We are so proud of her as she receives this highly competitive grant.

May 3, 2023
Hannah Johnston received the prestigious 2023 ASH Hematology Opportunities for the Next Generation of Research Scientists (HONORS) Award. Co-mentored by Dr. Chris Daugherty, Hannah will investigate the psychosocial determinants of health for patients with acute leukemia.

March 28, 2023
Dr. Caner Saygin received 2023 Cancer Research Foundation Young Investigator Award. This Award will support our work on TP53-mutant clonal hematopoiesis and its progression to acute leukemia.

June 7, 2022
Dr. Caner Saygin received American Society of Clinical Oncology and Conquer Cancer Foundation Young Investigator Award in memory of Sally Gordon. This Award is in direct support of the translational research program for experimental therapeutics in T-ALL.