The University of Chicago

Immunology

The ability of the immune system to mount a strong protective response depends on the receptor diversity of naive T-cells (TCR). Loss of thymic function and TCR diversity is thought to contribute to weaker immunosurveillance of the elderly, including increasing instances of diseases such as cancers, autoimmunity, and opportunistic infections.

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Computational Methods & Tools Developed in the Kleinstein Lab

pRESTO (REpertoire Sequencing TOolkit) is an integrated collection of platform-independent Python modules for processing raw reads from high-throughput (next-generation) sequencing of lymphocyte repertoires. pRESTO processes raw sequences to produce error-corrected,...

More precise diagnostics for improved cancer outcomes

More precise diagnostics for improved cancer outcomes

Credit: Kai Tian, Karl Decker, Aleksei Aksimentiev, and Li-Qun Gu, University of Missouri, University of Illinois at Urbana-Champaign An important factor in fighting cancer is the speed at which the disease can be identified, diagnosed and treated. The current...

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