Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Bugno J, Wang L, Yu X, Cao X, Wang J, Huang X, Yang K, Piffko A, Chen K, Luo SY, Naccasha E, Hou Y, Fu S, He C, Fu YX, Liang HL, Weichselbaum RR. Clin Cancer Res. 2024 May 1. doi: 10.1158/1078-0432.CCR-23-3616. Epub ahead of print. PMID: 38691100.
Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites. Hou Y, Yang K, Wang L, Wang J, Huang X, Piffko A, Luo SZ, Yu X, Rao E, Martinez C, Bugno J, Mack M, Vokes EE, Pitroda SP, Chmura SJ, Weichselbaum RR, Liang HL. Clin Cancer Res. 2024 Mar 1. doi: 10.1158/1078-0432.CCR-23-3206. PMID: 38427437.
Epitranscriptional regulation of TGF-β pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. Wang L, Si W, Yu X, Piffko A, Dou X, Ding X, Bugno J, Yang K, Wen C, Zhang L, Chen D, Huang X, Wang J, Arina A, Pitroda S, Chmura SJ, He C, Liang HL, Weichselbaum R. J Clin Invest. 2023 Dec 15;133(24):e172919. doi: 10.1172/JCI172919. PMID: 38099498; PMCID: PMC10721150.
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy. Wang L, Dou X, Chen S, Yu X, Huang X, Zhang L, Chen Y, Wang J, Yang K, Bugno J, Pitroda SP, Ding X, Piffko A, Si W, Chen C, Jiang H, Zhou B, Chmura SJ, Luo C, Liang HL, He C, Weichselbaum RR. Cancer Cell. 2023 May 25. doi: 10.1016/j.ccell.2023.04.019
Oligometastases: Characterizing the Role of Epigenetic Regulation of Epithelial-Mesenchymal Transition. Katipally RR, Pitroda SP, Weichselbaum RR, Hellman S. Clin Cancer Res. 2023 Apr 28:CCR-23-0376. doi: 10.1158/1078-0432.CCR-23-0376. PMID: 37115507.
Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration. Nat Nanotechnol. 2022 Oct 27. doi: 10.1038/s41565-022-01225-x. PMID: 36302963
The oligometastatic spectrum in the era of improved detection and modern systemic therapy.
All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages. Rao E, Hou Y, Huang X, Wang L, Wang J, Zheng W, Yang H, Yu X, Yang K, Bugno J, Ding X, Vokes EE, Fu YX, Weichselbaum RR, Liang HL. Science Immunology. 11 Jun 2021:Vol. 6, Issue 60, eaba8426; doi: 10.1126/sciimmunol.aba8426
Radiotherapy and Immunotherapy Combinations in the Treatment of Patients with Metastatic Disease: Current Status and Future Focus. Turchan WT, Pitroda SP, Weichselbaum RR. Clin Cancer Res. 2021 Jun 17. doi: 10.1158/1078-0432.CCR-21-0145. Online ahead of print.PMID: 34140404 Review.
The AIM2 and NLRP3 inflammasomes trigger IL-1-mediated antitumor effects during radiation. Han C, Godfrey V, Liu Z, Han Y, Liu L, Peng H, Weichselbaum RR, Zaki H, Fu YX. Sci Immunol. 2021 May 7;6(59):eabc6998. doi: 10.1126/sciimmunol.abc6998.PMID: 33963060
Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade.Si W, Liang H, Bugno J, Xu Q, Ding X, Yang K, Fu Y, Weichselbaum RR, Zhao X, Wang L. Gut. 2021 Mar 8;gutjnl-2020-323426. doi: 10.1136/gutjnl-2020-323426.PMID: 33685966
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity. Hou Y, Liang HL, Yu X, Liu Z, Cao X, Rao E, Huang X, Wang L, Li L, Bugno J, Fu Y, Chmura SJ, Wu W, Luo SZ, Zheng W, Arina A, Jutzy J, McCall AR, Vokes EE, Pitroda SP, Fu YX, Weichselbaum RR. Sci Transl Med. 2021 Feb 24;13(582):eabb0130. doi: 10.1126/scitranslmed.abb0130.PMID: 33627484
Suppression of local type I interferon by gut microbiota-derived butyrate impairs antitumor effects of ionizing radiation. Yang K, Hou Y, Zhang Y, Liang H, Sharma A, Zheng W, Wang L, Torres R, Tatebe K, Chmura SJ, Pitroda SP, Gilbert JA, Fu YX, Weichselbaum RR. J Exp Med. 2021 Mar 1;218(3):e20201915. doi: 10.1084/jem.20201915.PMID: 33496784
RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy. Zheng W, Ranoa DRE, Huang X, Hou Y, Yang K, Poli EC, Beckett MA, Fu YX, Weichselbaum RR. Cancer Res. 2020 Dec 15;80(24):5633-5641. doi: 10.1158/0008-5472.CAN-20-2324. Epub 2020 Oct 21.PMID: 33087322
Oligometastasis: Past, Present, Future. Gutiontov SI, Pitroda SP, Weichselbaum RR. Int J Radiat Oncol Biol Phys. 2020 Nov 1;108(3):530-538. doi: 10.1016/j.ijrobp.2020.02.019.PMID: 32976785 Review
Nanoscale metal-organic frameworks for x-ray activated in situ cancer vaccination. Ni K, Lan G, Guo N, Culbert A, Luo T, Wu T, Weichselbaum RR, Lin W. Sci Adv. 2020 Oct 2;6(40):eabb5223. doi: 10.1126/sciadv.abb5223. Print 2020 Oct. PMID: 33008911 Free PMC article.
4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis. Bryan DS, Stack M, Krysztofiak K, Cichon U, Thomas DG, Surcel A, Schiffhauer ES, Beckett MA, Khodarev NN, Xue L, Poli EC, Pearson AT, Posner MC, Robinson DN, Rock RS, Weichselbaum RR. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22423-22429. doi: 10.1073/pnas.2014639117.
Radiotherapy and Immunotherapy for Cancer: From “Systemic” to “Multisite”. Arina A, Gutiontov SI, Weichselbaum RR. Clin Cancer Res. 2020 Jun 15;26(12):2777-2782. doi: 10.1158/1078-0432.CCR-19-2034. Epub 2020 Feb 11.PMID: 32047000 Review.
Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling. Shi Y, Zheng W, Yang K, Harris KG, Ni K, Xue L, Lin W, Chang EB, Weichselbaum RR, Fu YX. J Exp Med. 2020 May 4;217(5):e20192282. doi: 10.1084/jem.20192282.PMID: 32142585
Integrated molecular and clinical staging defines the spectrum of metastatic cancer. Pitroda SP, Weichselbaum RR. Nat Rev Clin Oncol. 2019 Sep;16(9):581-588. doi: 10.1038/s41571-019-0220-6.PMID: 31092903 Review.
Tumor-reprogrammed resident T cells resist radiation to control tumors. Arina A, Beckett M, Fernandez C, Zheng W, Pitroda S, Chmura SJ, Luke JJ, Forde M, Hou Y, Burnette B, Mauceri H, Lowy I, Sims T, Khodarev N, Fu YX, Weichselbaum RR. Nat Commun. 2019 Sep 2;10(1):3959. doi: 10.1038/s41467-019-11906-2.PMID: 31477729
Integration of radiotherapy and immunotherapy for treatment of oligometastases. Pitroda SP, Chmura SJ, Weichselbaum RR. Lancet Oncol. 2019 Aug;20(8):e434-e442. doi: 10.1016/S1470-2045(19)30157-3. Epub 2019 Jul 29.PMID: 31364595 Review.
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C. Nature. 2019 Feb;566(7743):270-274. doi: 10.1038/s41586-019-0916-x. Epub 2019 Feb 6.PMID: 30728504
The 46th David A. Karnofsky Memorial Award Lecture: Oligometastasis-From Conception to Treatment. Weichselbaum RR. J Clin Oncol. 2018 Nov 10;36(32):3240-3250.
Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Hou Y, Liang H, Rao E, Zheng W, Huang X, Deng L, Zhang Y, Yu X, Xu M, Mauceri H, Arina A, Weichselbaum RR, Fu YX. Immunity. 2018 Sep 18;49(3):490-503.e4. doi: 10.1016/j.immuni.2018.07.008. Epub 2018 Aug 28.PMID: 30170810
Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Ni K, Lan G, Chan C, Quigley B, Lu K, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nat Commun. 2018 Jun 15;9(1):2351. doi: 10.1038/s41467-018-04703-w.
Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Nat Commun. 2018 May 4;9(1):1793. doi: 10.1038/s41467-018-04278-6.PMID: 29728604
Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy. Lu K, He C, Guo N, Chan C, Ni K, Lan G, Tang H, Pelizzari C, Fu YX, Spiotto MT, Weichselbaum RR, Lin W. Nat Biomed Eng. 2018 Aug;2(8):600-610. doi: 10.1038/s41551-018-0203-4. Epub 2018 Mar 26.PMID: 31015630
BCL3 expression promotes resistance to alkylating chemotherapy in gliomas. Wu L, Bernal GM, Cahill KE, Pytel P, Fitzpatrick CA, Mashek H, Weichselbaum RR, Yamini B. Sci Transl Med. 2018 Jul 4;10(448):eaar2238. doi: 10.1126/scitranslmed.aar2238.PMID: 29973405
Host STING-dependent MDSC mobilization drives extrinsic radiation resistance. Liang H, Deng L, Hou Y, Meng X, Huang X, Rao E, Zheng W, Mauceri H, Mack M, Xu M, Fu YX, Weichselbaum RR. Nat Commun. 2017 Nov 23;8(1):1736. doi: 10.1038/s41467-017-01566-5.PMID: 29170400
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, Chen X, Li XD, Deng L, Chen ZJ, Weichselbaum RR, Fu YX. Immunity. 2017 Aug 15;47(2):363-373.e5. doi: 10.1016/j.immuni.2017.07.016. Epub 2017 Aug 8.PMID: 28801234
Tumour ischaemia by interferon-g resembles physiological blood vessel regression. Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T. Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.PMID: 28445461
Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy. Xu M, Pu Y, Weichselbaum RR, Fu YX. Oncogene. 2017 Feb 2;36(5):585-592. doi: 10.1038/onc.2016.231. Epub 2016 Jul 18.PMID: 27425593 Free PMC article. Review.
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR. Immunity. 2014 Nov 20;41(5):843-52. doi: 10.1016/j.immuni.2014.10.019. Epub 2014 Nov 6.PMID: 25517616
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX. J Clin Invest. 2014 Feb;124(2):687-95. doi: 10.1172/JCI67313. Epub 2014 Jan 2.PMID: 24382348
Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing. Liang H, Deng L, Chmura S, Burnette B, Liadis N, Darga T, Beckett MA, Lingen MW, Witt M, Weichselbaum RR, Fu YX. J Immunol. 2013 Jun 1;190(11):5874-81. doi: 10.4049/jimmunol.1202612. Epub 2013 Apr 29.PMID: 23630355