Clark Lab- University of Chicago

Marcus Clark

Principle Investigator

Margaret Veselits

Margaret Veselits

Lab Manager

Margaret has been involved in studying the signaling and trafficking of the B cell receptor.  She is currently working on identifying the different populations of immune cells present in biopsies of kidneys from Lupus Nephritis patients.  Outside of the lab, she enjoys spending time with family & friends, trying her hand and new recipes, traveling and doing agility with her dog.

Malay Mandal

Malay Mandal

Research Associate Professor

Malay has a number of scientific interests, including understanding the mechanism of Immunoglobulin gene reaarngement, how bone marrow extracellular cues coordinate with intracellular signaling during early B lymphopoiesis, and how molecular effectors in shaping B cell mediated humoral immune response. Additionally, Malay is interested in understanding the molecular pathways of CD4 vs CD8 lineage commitment during T lymphopoiesis.

Junting (Lily) Ai

Junting (Lily) Ai

Technologist

Ph.D.- University of Kentucky
B.S.- Southern Medical University, China

Lily is interested in studying the in situ inflammation of various tissue in inflammatory diseases by immunostaining and imaging, especially interested in immune cell interaction in situ. Outside of the lab, she enjoys cooking, yoga and playing piano.

Rebecca Abraham

Rebecca Abraham

Graduate Student- M.D./Ph.D. in Immunology

B.S.- University of Florida

Rebecca’s project is focused on identifying interactions between antigen presenting cells and CD4 T cells in lupus. She uses microscopy and machine learning techniques to characterize how tissue-infiltrating immune populations form organized networks. When she’s not squinting at pictures of tumors, she likes to dance!

Nathaniel Wright

Nathaniel Wright

Graduate Student- M.D./Ph.D. in Immunology

B.S.- Wheaton College, 2017

Nathaniel is interested in the humoral immune response, specifically the molecular regulation of germinal centers, T-B cell interactions, and vaccine responses. Outside of lab, he enjoys soccer, singing, and hiking.

ORCID

Gabriel Casella

Gabriel Casella

Graduate Student- M.D./Ph.D. in Genetics, Genomics, and Systems Biology

B.S.- Johns Hopkins University, 2017

Gabriel is interested in leveraging machine learning and data science to understand how the spatial organization of immune cells in tissue affects disease, particularly in lupus nephritis. Outside of the lab, he enjoys biking, cooking, gardening, and playing with his cat. 

 

Jenna Guthmiller

Postdoctoral Fellow

Ph.D. University of Oklahoma Health Sciences Center, 2017
B.S.- South Dakota State University, 2013

Jenna is studying the development and regulation of broadly neutralizing antibody responses against influenza viruses. With a K99 from NIAID, she is continuing her studies to understand how epitope specificity shapes B cell development and function. In her free time, she enjoys listening to podcasts, binging the hottest new TV show, and hanging out with her human and feline friends. She is moving to the University of Colorado Anschutz Medical Campus in 2022 to start her own lab.

Former Lab Members

Domenick Kennedy

Domenick Kennedy

Postdoctoral Fellow

Ph.D.- Loyola University Chicago
B.S.- University of Illinois Urbana-Champaign

Domenick’s research focuses on the molecular regulation and dynamics of humoral immune responses. By integrating information at the epigenetic, transcriptional, and protein levels he is building a comprehensive model that highlights the complexity underlying peripheral B cell responses. He is also working to discover therapeutic targets to boost immune responses to vaccination and intervene in scenarios of dysregulation that result in immunodeficiency, autoimmunity, and cancer.

Domenick was awarded a F32 postdoctoral fellowship F32 AI143120-01 entitled BRWD1 and the molecular regulation of humoral immunity.

ORCID

Kaitlin McLean

Kaitlin McLean

Graduate Student- MD./Ph.D. in Developmental, Regenerative, and Stem Cell Biology

B.S.- Yale University, 2013

Kaitlin studies the epigenetics of B cell development, focusing on how an epigenetic reader, Brwd1, regulates Igk recombination. She is especially interested in how accessibility and transcription in the Igk locus affects repertoire choice and diversity, and leverages CRISPR-Cas 9 and next-generation sequencing techniques to investigate these questions. Outside of the lab, she enjoys dancing, baking, and playing with her cat.

ORCID

Michael K Okoreeh

Michael K Okoreeh

Graduate Student- MD/Ph.D . in Immunology

B.S.- University of California, Riverside, 2014

Michael is interested in autoimmunity and understanding the molecular mechanisms of tolerance during B cell development. He uses genetic models and bioinformatic techniques to address these questions. Outside of lab, Michael mentors minority high school students to pursue STEM related majors in college as a part of the nonprofit Target H.O.P.E. He also enjoys cooking, attending live concerts and sports. 

ORCID

Yuta Asano

Yuta Asano

Post-Doctoral Scholar

Ph.D.- University of Chicago, 2020
B.S.- University of Tokyo, 2013

Yuta is interested in how B cells activated in local tissues promote inflammation. He investigates this in human renal transplant rejection using transcriptomics and molecular biology tools. In his free time, he enjoys climbing and chilling with cats.