2024

BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function. bioRxiv [Preprint]. Wright NE, Kennedy DE, Ai J, Veselits ML, Attaway M, Yoon YM, Durkee MS, Veselits J, Maienschein-Cline M, Mandal M, Clark MR. B. 2024 Apr 28:2024.04.25.591154. PMID: 38712068.

Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes. Wright NE, Mandal M, Clark MR. Trends Immunol. 2023 Aug 10:S1471-4906(23)00134-5. Online ahead of print. PMID: 37573227

Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies. Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI. medRxiv. 2023 May 11:2023.05.08.23289640. PMID: 37214861

STAT3 signaling in B cells controls germinal center zone organization and recycling. Fike AJ, Chodisetti SB, Wright NE, Bricker KN, Domeier PP, Maienschein-Cline M, Rosenfeld AM, Luckenbill SA, Weber JL, Choi NM, Luning Prak ET, Mandal M, Clark MR, Rahman ZSM. Cell Rep. 2023 May 30;42(5):112512. PMID: 37200190

The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state. Lee V, Rodriguez DM, Ganci NK, Zeng S, Ai J, Chao JL, Walker MT, Miller CH, Klawon DEJ, Schoenbach MH, Kennedy DE, Maienschein-Cline M, Socci ND, Clark MR, Savage PA. Nat Immunol. 2023 Mar;24(3):487-500. PMID: 36759711

The ion transporter Na⁺-K⁺-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen PM, Chandra N, Cantley L, Veselits M, Clark MR, Craft J. Sci Adv. 2023 Feb 3;9(5):eadf8156. PMID: 36724234

2022

IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses. Camacho DF, Velez TE, Hollinger MK, Wang E, Howard CL, Darnell EP, Kennedy DE, Krishack PA, Hrusch CL, Clark MR, Moon JJ, Sperling AI. JCI Insight. 2022 Nov 8;7(21):e140384. PMID: 36194494

Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing. Okoreeh MK, Kennedy DE, Emmanuel AO, Veselits M, Moshin A, Ladd RH, Erickson S, McLean KC, Madrigal B, Nemazee D, Maienschein-Cline M, Mandal M, Clark MR. Sci Immunol. 2022 Aug 5;7(74):eabm1664. PMID: 35930652

Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis. Abraham R, Durkee MS, Ai J, Veselits M, Casella G, Asano Y, Chang A, Ko K, Oshinsky C, Peninger E, Giger ML, Clark MR. J Clin Invest. 2022 Jul 1;132(13):e155350. PMID: 35608910

Positive and negative selection shape the human naive B cell repertoire. Chen JW, Schickel JN, Tsakiris N, Sng J, Arbogast F, Bouis D, Parisi D, Gera R, Boeckers JM, Delmotte FR, Veselits M, Schuetz C, Jacobsen EM, Posovszky C, Schulz AS, Schwarz K, Clark MR, Menard L, Meffre E. J Clin Invest. 2022 Jan 18;132(2):e150985. PMID: 34813502

2021

Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Asano Y, Daccache J, Jain D, Ko K, Kinloch A, Veselits M, Wolfgeher D, Chang A, Josephson M, Cunningham P, Tambur A, Khan AA, Pillai S, Chong AS, Clark MR. Nat Commun. 2021 Jul 16;12(1):4372. PMID: 34272370

Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images. Durkee MS, Abraham R, Clark MR, Giger ML. Am J Pathol. 2021 Oct;191(10):1693-1701. PMID: 34129842

Compartments and Connections Within the Germinal Center. Kennedy DE, Clark MR. Front Immunol. 2021 Mar 31;12:659151. PMID: 33868306

Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis. Durkee MS, Abraham R, Ai J, Veselits M, Clark MR, Giger ML. J Biomed Opt. 2021 Jan;26(2):022910. PMID: 33420765

Cellular aspects of the pathogenesis of lupus nephritis. Chang A, Clark MR, Ko K. Curr Opin Rheumatol. 2021 Mar 1;33(2):197-204. PMID: 33394604

2020

Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation. Kinloch AJ, Asano Y, Mohsin A, Henry C, Abraham R, Chang A, Labno C, Wilson PC, Clark MR. Front Immunol. 2020 Nov 27;11:593177. PMID: 33329582

Control of Early B Cell Development by the RNA N⁶-Methyladenosine Methylation. Zheng Z, Zhang L, Cui XL, Yu X, Hsu PJ, Lyu R, Tan H, Mandal M, Zhang M, Sun HL, Sanchez Castillo A, Peng J, Clark MR, He C, Huang H. Cell Rep. 2020 Jun 30;31(13):107819. PMID: 32610122

Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IA. J Autoimmun. 2020 Sep;113:102469. PMID: 32362501

Novel specialized cell state and spatial compartments within the germinal center. Kennedy DE, Okoreeh MK, Maienschein-Cline M, Ai J, Veselits, M, McLean KC, Dhugana, Y, Wang, H, Peng, J, Chi, H, Mandal, M, Clark MR. Nat Immunol. 2020. Jun;21(6):660-670. PMID: 32341509

Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Sci Transl Med. 2020 Apr 8;12(538):eaay1620. PMID: 32269165

Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis. Kinloch AJ, Cascino MD, Dai J, Bermea RS, Ko K, Vesselits M, Dragone LL, Mor Vaknin N, Legendre M, Markovitz DM, Okoreeh MK, Townsend MJ, Clark MR. Lupus. 2020;29(6):569-577. PMID: 32216516

2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage. Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA. Nat Commun. 2019 Oct 18;10(1):4768. PMID: 31628339

CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR. Nat Immunol. 2019 Oct;20(10):1393-1403. PMID: 31477919

Transcription factories in Igκ allelic choice and diversity. Karki S, Banerjee S, Mclean K, Dinner A, Clark MR. Adv Immunol. 2019;141:33-49. PMID: 30904132

Quantifying in situ adaptive immune cell cognate interactions in humans. Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Nat Immunol. 2019 Apr;20(4):503-513. PMID: 30778242

2018

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Mandal M, Maienschein-Cline M, Maffucci P, Veselits M, Kennedy DE, McLean KC, Okoreeh MK, Karki S, Cunningham-Rundles C, Clark MR. Nat Commun. 2018 Sep 24;9(1):3888. PMID: 30250168

Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories. Karki S, Kennedy DE, Mclean K, Grzybowski AT, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, Clark MR. Cell Rep. 2018 Aug 28;24(9):2443-2456. PMID: 30157436

PI3Kδ: Too much of a good thing. Kennedy DE, Clark MR. Nat Immunol. 2018 Sep;19(9):910-911. PMID: 30127436

In Situ Humoral Immunity to Vimentin in HLA-DRB1*03⁺ Patients With Pulmonary Sarcoidosis. Kinloch AJ, Kaiser Y, Wolfgeher D, Ai J, Eklund A, Clark MR, Grunewald J. Front Immunol. 2018 Jul 9;9:1516. PMID: 30038611

2017

Igβ ubiquitination activates PI3K signals required for endosomal sorting. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O’Neill SK, Wilson P, Sciammas R, Clark MR. J Exp Med. 2017 Dec 4;214(12):3775-3790. PMID: 29141870

EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. Immunol. 2017 Jun 15;198(12):4682-4691. PMID: 28490575

2016

Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation. Ko K, Wang J, Perper S, Jiang Y, Yanez D, Kaverina N, Ai J, Liarski VM, Chang A, Peng Y, Lan L, Westmoreland S, Olson L, Giger ML, Chun Wang L, Clark MR. Arthritis Rheumatol. 2016 Nov;68(11):2740-2751. PMID: 27159593

Overview of pathophysiology and treatment of human lupus nephritis. Trotter K, Clark MR, Liarski VM. Curr Opin Rheumatol. 2016 Sep;28(5):460-7. PMID: 27341623

Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA.Nat Immunol. 2016 Feb;17(2):196-203. PMID: 26692173

2015

The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis. Clark MR, Trotter K, Chang A. Semin Nephrol. 2015 Sep;35(5):455-64. PMID: 26573548

Histone reader BRWD1 targets and restricts recombination to the Igk locus. Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR. Nat Immunol. 2015 Oct;16(10):1094-103. PMID: 26301565

RAG Represents a Widespread Threat to the Lymphocyte Genome. Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Mandal M, Ji Y, Meffre E, Clark MR, Cowell LG, Casellas R, Schatz DG. Cell. 2015 Aug 13;162(4):751-65. PMID: 26234156

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2024

BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function. bioRxiv [Preprint]. Wright NE, Kennedy DE, Ai J, Veselits ML, Attaway M, Yoon YM, Durkee MS, Veselits J, Maienschein-Cline M, Mandal M, Clark MR. B. 2024 Apr 28:2024.04.25.591154. PMID: 38712068.

Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS. Hu Y, Salgado Figueroa D, Zhang Z, Veselits M, Bhattacharyya S, Kashiwagi M, Clark MR, Morgan BA, Ay F, Georgopoulos K. Cell. 2023 Nov 22;186(24):5269-5289.e22. PMID: 37995656

BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin. Mandal M, Maienschein-Cline M, Hu Y, Mohsin A, Veselits ML, Wright NE, Okoreeh MK, Yoon YM, Veselits J, Georgopoulos K, Clark MR. Nat Immunol. 2023 Nov 20. doi: 10.1038/s41590-023-01666-z. PMID: 37985858

Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes. Wright NE, Mandal M, Clark MR. Trends Immunol. 2023 Aug 10:S1471-4906(23)00134-5. Online ahead of print. PMID: 37573227

Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies. Yoon YM, Velez TE, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DC, Clark MR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Anderson M, DeRisi JL, Shum AK, Sperling AI. medRxiv. 2023 May 11:2023.05.08.23289640. PMID: 37214861

STAT3 signaling in B cells controls germinal center zone organization and recycling. Fike AJ, Chodisetti SB, Wright NE, Bricker KN, Domeier PP, Maienschein-Cline M, Rosenfeld AM, Luckenbill SA, Weber JL, Choi NM, Luning Prak ET, Mandal M, Clark MR, Rahman ZSM. Cell Rep. 2023 May 30;42(5):112512. PMID: 37200190

The endogenous repertoire harbors self-reactive CD4⁺ T cell clones that adopt a follicular helper T cell-like phenotype at steady state. Lee V, Rodriguez DM, Ganci NK, Zeng S, Ai J, Chao JL, Walker MT, Miller CH, Klawon DEJ, Schoenbach MH, Kennedy DE, Maienschein-Cline M, Socci ND, Clark MR, Savage PA. Nat Immunol. 2023 Mar;24(3):487-500. PMID: 36759711

The ion transporter Na⁺-K⁺-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Chernova I, Song W, Steach H, Hafez O, Al Souz J, Chen PM, Chandra N, Cantley L, Veselits M, Clark MR, Craft J. Sci Adv. 2023 Feb 3;9(5):eadf8156. PMID: 36724234

2022

IRF4 expression by lung dendritic cells drives acute but not Trm cell-dependent memory Th2 responses. Camacho DF, Velez TE, Hollinger MK, Wang E, Howard CL, Darnell EP, Kennedy DE, Krishack PA, Hrusch CL, Clark MR, Moon JJ, Sperling AI. JCI Insight. 2022 Nov 8;7(21):e140384. PMID: 36194494

Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing. Okoreeh MK, Kennedy DE, Emmanuel AO, Veselits M, Moshin A, Ladd RH, Erickson S, McLean KC, Madrigal B, Nemazee D, Maienschein-Cline M, Mandal M, Clark MR. Sci Immunol. 2022 Aug 5;7(74):eabm1664. PMID: 35930652

Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis. Abraham R, Durkee MS, Ai J, Veselits M, Casella G, Asano Y, Chang A, Ko K, Oshinsky C, Peninger E, Giger ML, Clark MR. J Clin Invest. 2022 Jul 1;132(13):e155350. PMID: 35608910

Positive and negative selection shape the human naive B cell repertoire. Chen JW, Schickel JN, Tsakiris N, Sng J, Arbogast F, Bouis D, Parisi D, Gera R, Boeckers JM, Delmotte FR, Veselits M, Schuetz C, Jacobsen EM, Posovszky C, Schulz AS, Schwarz K, Clark MR, Menard L, Meffre E. J Clin Invest. 2022 Jan 18;132(2):e150985. PMID: 34813502

2021

Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Asano Y, Daccache J, Jain D, Ko K, Kinloch A, Veselits M, Wolfgeher D, Chang A, Josephson M, Cunningham P, Tambur A, Khan AA, Pillai S, Chong AS, Clark MR. Nat Commun. 2021 Jul 16;12(1):4372. PMID: 34272370

Artificial Intelligence and Cellular Segmentation in Tissue Microscopy Images. Durkee MS, Abraham R, Clark MR, Giger ML. Am J Pathol. 2021 Oct;191(10):1693-1701. PMID: 34129842

Compartments and Connections Within the Germinal Center. Kennedy DE, Clark MR. Front Immunol. 2021 Mar 31;12:659151. PMID: 33868306

Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis. Durkee MS, Abraham R, Ai J, Veselits M, Clark MR, Giger ML. J Biomed Opt. 2021 Jan;26(2):022910. PMID: 33420765

Cellular aspects of the pathogenesis of lupus nephritis. Chang A, Clark MR, Ko K. Curr Opin Rheumatol. 2021 Mar 1;33(2):197-204. PMID: 33394604

2020

Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation. Kinloch AJ, Asano Y, Mohsin A, Henry C, Abraham R, Chang A, Labno C, Wilson PC, Clark MR. Front Immunol. 2020 Nov 27;11:593177. PMID: 33329582

Control of Early B Cell Development by the RNA N⁶-Methyladenosine Methylation. Zheng Z, Zhang L, Cui XL, Yu X, Hsu PJ, Lyu R, Tan H, Mandal M, Zhang M, Sun HL, Sanchez Castillo A, Peng J, Clark MR, He C, Huang H. Cell Rep. 2020 Jun 30;31(13):107819. PMID: 32610122

Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu. Zhang D, Kinloch AJ, Srinath A, Shenkar R, Girard R, Lightle R, Moore T, Koskimäki J, Mohsin A, Carrión-Penagos J, Romanos S, Shen L, Clark MR, Shi C, Awad IA. J Autoimmun. 2020 Sep;113:102469. PMID: 32362501

Novel specialized cell state and spatial compartments within the germinal center. Kennedy DE, Okoreeh MK, Maienschein-Cline M, Ai J, Veselits, M, McLean KC, Dhugana, Y, Wang, H, Peng, J, Chi, H, Mandal, M, Clark MR. Nat Immunol. 2020. Jun;21(6):660-670. PMID: 32341509

Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis. Chen PM, Wilson PC, Shyer JA, Veselits M, Steach HR, Cui C, Moeckel G, Clark MR, Craft J. Sci Transl Med. 2020 Apr 8;12(538):eaay1620. PMID: 32269165

Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis. Kinloch AJ, Cascino MD, Dai J, Bermea RS, Ko K, Vesselits M, Dragone LL, Mor Vaknin N, Legendre M, Markovitz DM, Okoreeh MK, Townsend MJ, Clark MR. Lupus. 2020;29(6):569-577. PMID: 32216516

2019

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage. Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA. Nat Commun. 2019 Oct 18;10(1):4768. PMID: 31628339

CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR. Nat Immunol. 2019 Oct;20(10):1393-1403. PMID: 31477919

Transcription factories in Igκ allelic choice and diversity. Karki S, Banerjee S, Mclean K, Dinner A, Clark MR. Adv Immunol. 2019;141:33-49. PMID: 30904132

Quantifying in situ adaptive immune cell cognate interactions in humans. Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR. Nat Immunol. 2019 Apr;20(4):503-513. PMID: 30778242

2018

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Mandal M, Maienschein-Cline M, Maffucci P, Veselits M, Kennedy DE, McLean KC, Okoreeh MK, Karki S, Cunningham-Rundles C, Clark MR. Nat Commun. 2018 Sep 24;9(1):3888. PMID: 30250168

Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories. Karki S, Kennedy DE, Mclean K, Grzybowski AT, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, Clark MR. Cell Rep. 2018 Aug 28;24(9):2443-2456. PMID: 30157436

PI3Kδ: Too much of a good thing. Kennedy DE, Clark MR. Nat Immunol. 2018 Sep;19(9):910-911. PMID: 30127436

In Situ Humoral Immunity to Vimentin in HLA-DRB1*03⁺ Patients With Pulmonary Sarcoidosis. Kinloch AJ, Kaiser Y, Wolfgeher D, Ai J, Eklund A, Clark MR, Grunewald J. Front Immunol. 2018 Jul 9;9:1516. PMID: 30038611

2017

Igβ ubiquitination activates PI3K signals required for endosomal sorting. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O’Neill SK, Wilson P, Sciammas R, Clark MR. J Exp Med. 2017 Dec 4;214(12):3775-3790. PMID: 29141870

EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. Immunol. 2017 Jun 15;198(12):4682-4691. PMID: 28490575

2016

Bcl-2 as a Therapeutic Target in Human Tubulointerstitial Inflammation. Ko K, Wang J, Perper S, Jiang Y, Yanez D, Kaverina N, Ai J, Liarski VM, Chang A, Peng Y, Lan L, Westmoreland S, Olson L, Giger ML, Chun Wang L, Clark MR. Arthritis Rheumatol. 2016 Nov;68(11):2740-2751. PMID: 27159593

Overview of pathophysiology and treatment of human lupus nephritis. Trotter K, Clark MR, Liarski VM. Curr Opin Rheumatol. 2016 Sep;28(5):460-7. PMID: 27341623

Self-reactive IgE exacerbates interferon responses associated with autoimmunity. Henault J, Riggs JM, Karnell JL, Liarski VM, Li J, Shirinian L, Xu L, Casey KA, Smith MA, Khatry DB, Izhak L, Clarke L, Herbst R, Ettinger R, Petri M, Clark MR, Mustelin T, Kolbeck R, Sanjuan MA.Nat Immunol. 2016 Feb;17(2):196-203. PMID: 26692173

2015

The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis. Clark MR, Trotter K, Chang A. Semin Nephrol. 2015 Sep;35(5):455-64. PMID: 26573548

Histone reader BRWD1 targets and restricts recombination to the Igk locus. Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR. Nat Immunol. 2015 Oct;16(10):1094-103. PMID: 26301565

RAG Represents a Widespread Threat to the Lymphocyte Genome. Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Mandal M, Ji Y, Meffre E, Clark MR, Cowell LG, Casellas R, Schatz DG. Cell. 2015 Aug 13;162(4):751-65. PMID: 26234156

See more