Papers/Presentations

   Publications:

  • P. Brugarolas, R. Freifelder, S.-H. Cheng, O. de Jesus. Synthesis of 3-[18F]fluoro-4-aminopyridine from pyridine N-oxide precursors, Chem. Comm. 52 (2016) pp. 7150-7152.
  • P. Brugarolas, M.P.I. Bhuiyan, A. Kucharski, R. Freifelder. Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging De- myelinating Diseases, J. Vis.Exp. 123 (2017) e55537.
  • P. Brugarolas, J.E. Sánchez-Rodríguez, H.-M. Tsai, F. Basuli, S.-H. Cheng, X. Zhang, A.V. Caprariello, J.J. Lacroix, R. Freifelder, D. Murali, O. DeJesus, R.H. Miller, R.E. Swenson, C.-T. Chen, P. Herscovitch, D.S. Reich, F. Bezanilla, and B. Popko, B.  Development of a PET radioligand for potassium channels to image CNS demyelination. Scientific Reports, 8 (2018) 607.
  • J.W. Chang, M. Bhuiyan, H.-M. Tsai, H.J. Zhang, G. Li, S. Fathi, D.C. McCutcheon, L. Leoni, R. Freifelder, C.-T. Chen, and R.E. Moellering. In vivo imaging of the tumor-associated enzyme NCEH1 with a covalent PET probe, Angewandte Chemie International Edition, 59:15161–15165, (2020).
  • B.A. Broder, M.P. Bhuiyan, H.J. Zhang, R. Freifelder, H.-M. Tsai, A. Kucharski, L. Leoni, S. Mitchell, D. Bodero, C.-M. Kao, C.-T. Chen.  Improving the Synthesis of 48V labeled [VO(acac)2] and In-Vitro and In-Vivo Validation.   J. Nucl. Med. 61(2020) p. 1060.
  • S. Mitchell, H.J. Zhang, M.P. Bhuiyan, H.-M. Tsai, L. Leoni, R. Freifelder, B. Roman, C.-M. Kao, X. Zhuang, W. Green, J. Mukherjee, C.-T. Chen.  Gender Differences in Binding Kinetics of Nicotinic Acetylcholine Receptors Using microPET/CT with 2-[18F]FA-85380.  J. Nucl. Med.  61(2020) p. 82.
  • M. Bhuiyan, A. Kucharski, R. Freifelder, L. Won, R. Kraig, C.-T. Chen.  Semi-automatic radiolabeling of insulin-like growth factor-1 protein for the verification of its nose-to-brain delivery by positron emission tomography imaging.   J. Nucl. Med. 61(2020) p. 512.
  • H.J Zhang, S. Mitchell, Y.-H. Fang, H.-M. Tsai, L. Piao, A. Ousta, L. Leoni, C.-T. Chen W.W. Sharp, Assessment of brain glucose metabolism following cardiac arrest by [18F]FDG positron emission tomography, Neurocritical Care, 34:64–72, (2021).
  • H. Kim, B. Epel, S. Sundramoorthy, H.-M. Tsai, E. Barth, I. Gertsenshteyn, H. Halpern, Y. Hua, Q. Xie, C.-T. Chen, and C.-M. Kao.  Development of a PET/EPRI combined imaging system for assessing tumor hypoxia,  Journal of Instrumentation16(3): P03031, doi:10.1088/1748-0221/16/03/P03031, (2021).

  • M.C. Veronesi, B.D. Graner, S.-H. Cheng, M. Zamora, H. Zarrinmayeh, C.-T. Chen, S.K. Das, M.W. Vannier.  Aerosolized In Vivo 3D Localization of Nose-to-Brain Nanocarrier Delivery Using Multimodality Neuroimaging in a Rat Model—Protocol Development. Pharmaceutics, 13(3):391. doi: 10.3390/ pharmaceutics13030391, (2021).

  • I. Gertsenshteyn, B. Epel, E. Barth, L. Leoni, E. Markiewicz, X. Fan, M. Giurcanu, H-M. Tsai, M. Zamora, D. Bodero, S. Sundramoorthy, H-J. Kim, R. Freifelder, M. Bhuiyan, A. Kucharski, G. Karczmar, C-M. Kao, H. Halpern, and C-T. Chen. Improving Tumor Hypoxia Location in18F-Misonidazole PET with DCI-MRI Using Quantitation EPR pO2 Images.  Radiology: Imaging Cancer (2021), 3:2. https://pubs.rsna.org/doi/10.1148/rycan.2021200104, (2021).

  • B. Broder, M. Bhuiyan, R. Freifelder, H. Zhang, A. Kucharski, M. Makinen, D. Rotsch, C-T. Chen. Preliminary investigation of 48V-labeled VO(acac)2 for cancer imaging: An initial proof-of-concept study.  Applied Radiation and Isotopes, 186 (2022) 110270. j.apradiso.2022.110270

  • I. Gertsenshteyn, B. Epel, A. Ahluwalia, H-J. Kim, X. Fan, E. Barth, M. Zamora, E. Markiewicz, H-M. Tsai, L. Leoni, J. Lukens, M. Bhuiyan, R. Freifelder, A. Kucharski, M. Giurcanu, B. Roman, G. Karczmar, C-M. Kao, H. Halpern, C-T. Chen.  The optimal 18F-Fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth.  European Journal of Nuclear Medicine and Molecular Imaging (2022) https://doi.org/10.1007/s00259-022-05889-4.

  • H. Zhang, M. Zammit, C-M. Kao, A. Govind, S. Mitchell, N. Holderman, M. Bhuiyan, R. Freifelder, X. Zhuang, J. Mukherjee, C.-T. Chen, and W. Green. Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed by in vitro Cellular Studies and in vivo PET Imaging.  Journal of Neuroscience, 26 August 2022, JN-RM-2484-21; DOI: https://doi.org/10.1523/jneuosci.2484-21.2022.

  • M. Bhuiyan, W. Zeng, A. Kucharski, R. Freifelder, C.-T. Chen, L. Chen, Development of A Novel 18F-PET Imaging Probe for Pancreatic Cancer. Journal of Nuclear Medicine, 63 (supplement 2), 2357 (2022).

  • M. Bhuiyan, H. Zhang, J. Meier, N. Yamashita, P. Kankanamalage, T. Brossard, H.-M. Tsai, L. Leoni, A. Kucharski, R. Freifelder, J. Nolen, C.-M. Kao, D. Rotsch, R. Weichselbaum, D. Kufe, C.-T. Chen.  Targeting MUC1-C for Cancer Theranostics Using Humanized 47Sc-mAb 3D1. Journal of Nuclear Medicine, 63 (supplement 2), 2357 (2022).

  • B.A. Broder, R. Freifelder, A. Kucharski, and C.-T. Chen, Modeling cyclotron-based production of radioisotopes via TOPAS. 68, Phys. Med. Biol. (2023), 015017.

  • J. P. Meier, H. J. Zhang, R. Freifelder, M. Bhuiyan, P. Selman, M. Mendez, P.H.A. Kankanamalage, T. Brossard, A. Pusateri, H.-M. Tsai, L. Leoni, S. Penano, K. Ghosh, B. A. Broder, E. Markiewicz, A. Renne, W. Stadler, R. Weichselbaum, J. Nolen, C.-M. Kao, S.K. Chitneni, D.A. Rotsch, R.Z. Szmulewitz, C.-T. Chen, Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics, Molecules 2023, 28(16), 6041;  https://doi.org/10.3390/molecules28166041.

  • M. Zammit,  C.-M. Kao,  H. J. Zhang, H.-M. Tsai,  N. Holderman, S. Mitchell, E. Tanios,  M. Bhuiyan,  R. Freifelder, A. Kucharski,
    W.N. Green, J. Mukherjee and C.-T. Chen, Evaluation of an Image-Derived Input Function for Kinetic Modeling of Nicotinic Acetylcholine Receptor-Binding PET Ligands in Mice. Int. J. Mol. Sci. 24, 15510 (2023).                                https://doi.org/10.3990/ijms242115510
  • M. Bhuiyan, J. Souris, A. Kucharski, R. Freifelder, J. Mukherjee and C.-T. Chen, A simplified protocol for the automated production of 2-[18F]fluoro-3-[2-((S)-3-pyrrolinyl)methoxy]pyridine ([18F] nifene) on an IBA Synthera® module.  J. Label. Compd Radiopharm. 1 (2023) https://doi.org/10.1002/jlcr.4071

  • B.A. Broder, M. Bhuiyan, R. Freifelder, D.A. Rotsch, S.K. Chitneni, M.W. Makiene, and C.-T. Chen, Efficient Synthesis and HPLC-Based Characterization for Developing Vanadium-48-Labeled Vanadyl Acetylacetonate as a Novel Cancer Radiotracer for PET Imaging.  Molecules, 27, 799 (2024) https://doi.org/10.3390/molecules29040799 

Talks/Presentations (Invited):

  • InnMolecular imaging for intranasal drug development, L. Leoni, 2016 Midwest Preclinical Imaging Consortium University of Wisconsin – Madison, Madison, WI, May 15-17, 2016.
  • Molecular Imaging: At the Forefront of Medicine, But Firmly Rooted in Nuclear Physics, R. Freifelder, QCD Thermodynamics – Pressure and Passion, Schloss Waldthausen, Germany, Aug. 24-26, 2016.
  • Integrative Multi-Modality Molecular Imaging: Recent Progress at the UChicago, C.-T. Chen, Research Seminar, Gordon Center for Imaging Science, Massachusetts General Hospital/Harvard University Medical School, Boston MA, September 6, 2016.
  • Two Case Studies: Cyclotrons and cGMP Production Facilities for Two Universities, R, Freifelder, ISPE Annual Meeting, Atlanta, Sept. 18-21, 2016.
  • iSAIRR and Cyclotron Facilities. L. Leoni, 2017 Midwest Preclinical Consortium, Vanderbilt University, Nashville, TN, May 14-16, 2017.
  • Atoms for Peace in Medicine and Biology, C.-T. Chen, CP-1 Commemoration Event – The University of Chicago, Physics Colloquia, Chicago, IL Nov. 2, 2017.
  • Molecular Imaging & Theranostics with An Example of PRINT (Precision-RadioImmuno-NanoTheranostics), C.-T. Chen, Development Center for Biotechnology, Taipei, Taiwan, Dec. 12, 2017.
  • RadioTheranostic Strategies for Improving NSCLC Treatment Outcomes, C.-T. Chen, UChicago Comprehensive Cancer Center, Translational Seminar, Chicago, IL, Dec. 15, 2017.
  • Assessment of Photodynamic Therapy Efficacy of X-ray Activated Nanoscintillators Using 18F-FLT, H.-M. Tsai,  2018 Fourth Annual Invicro Software User Meeting, Boston MA, September 28, 2018.
  • Clinical Molecular Imaging – Firmly Rooted in Nuclear Physics, R. Freifelder, Physics Colloquium, George Washington University, Washington DC, February 28, 2019. 

  • The University of Chicago Cyclotron Facility and cGMP Radiotracer Production, R. Freifelder, 2019 Molecular Imaging Instrumentation Conference, Hong Kong, April 24-25, 2019.

  • 48V labeled VO(acac)2 for hybrid PET/MR imaging of cancer,  Brittany Broder, et.al., 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Preliminary Investigation of Hypoxia within Tumors Using EPRI, DCE‑MRI, and PET‑CT with 18F‑FMISO to Improve Radiotherapy, Inna Gertsenshteyn, et.al., 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Assessment of Photodynamic Therapy (PDT) Efficacy of X‑ray Activated Nanoscintillators Using 18F FLT in PET,  Lara Leoni et. al.,  2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Investigation of the binding kinetics of nicotinic acetylcholine receptors by PET/CT using fluorine‑18 labeled Nifene and 2‑Fluoro‑3‑(2(S)‑azetidinylmethoxy)pyridine,  Hannah J Zhang, Samuel Mitchell, et. al., 2019 Society of Nuclear Medicine and Molecular Imaging, Los Angeles, June 22-25, 2019.

  • Improving 18F-misonidazole hypoxia target map with EPR and DCE-MRI. Inna Gertsenshteyn, et. al. 2019 Radiological Society of North America, Chicago, December 1-5, 2019.
  • Semi-automatic radiolabeling of insulin-like growth factor-1 protein for the verification of its nose-to-brain delivery by positron emission tomography imaging.  Mohammed Bhuiyan, et.al.  2020 Society of Nuclear Medicine and Molecular Imaging Annual Conference.
  • Improving the Synthesis of 48V labeled [VO(acac)2] and In-Vitro and In-Vivo Validation, Brittany A. Broder, Mohammed P. Bhuiyan, Hannah J. Zhang, Richard Freifelder, Hsiu-Ming Tsai, Anna Kucharski, Lara Leoni, Samuel Mitchell, Darwin Bodero, Chien-Min Kao, Chin-Tu Chen.  2020 Society of Nuclear Medicine and Molecular Imaging Annual Conference.
  • Gender Differences in Binding Kinetics of Nicotinic Acetylcholine Receptors Using microPET/CT with 2-[18F]FA-85380.  Samuel Mitchell, Hannah J. Zhang, Mohammed P. Bhuiyan, Hsiu-Ming Tsai, Lara Leoni, Richard Freifelder, Brain Roman, Chien-Min Kao, Xiaoxi Zhuang, William Green, Jogeshwar Mukherjee, Chin-Tu Chen.   2020 Society of Nuclear Medicine and Molecular Imaging Annual Conference.
  • Topas Simulations for Estimating 48V Yields of Natural Titanium Foil Irradiation”, Brittany Broder, Richard Freifelder, Mohammed Bhuiyan, Anna Kucharski, Chin-Tu Chen.  Accepted for Presentation at the International Conference on Technology and Instrumentation in Particle Physics, 2021 (virtual).
  • Optimal 18F-Misonidazole PET threshold to locate SCC7 tumor hypoxia using EPR pO2as ground truth.  Inna Gertsenshetyn, Eugene Barth, Heejong Kim, Boris Epel, Lara Leoni, Hsiu-Ming Tsai, John Luken, Subramanian Sundramoorty, Mihai Giurcanu, Amandeep Ahluwalia, Xiaobing Fan, Erica Markiewicz, Marta Zamora, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Chien-Min Kao, Howard Halpern, Chin-Tu Chen.  2021 Society of Nuclear Medicine and Molecular Imaging Annual Conference (virtual).
  • Topaz Simulations for Estimating Cyclotron-Based Production Yield of Vanadium-48, Brittany Broder, Richard Freifelder, Anna Kucharski, Mohammed Bhuiyan, Amy Renne, Jerry Nolen, Chin-Tu Chen.  2021 Society of Nuclear Medicine and Molecular Imaging Annual Conference (virtual).
  • Positron emission tomography (PET) in vivo imaging of 2-[18F]-A85380 trapping in α4β2 receptor-containing acidic vesicles.  C.-M. Kao, H. Zhang, M. Zammit, N. Holderman, H.-M. Tsai, A. Govind, S.Mitchell, M. Bhuiyan, R. Freifelder, X. Zhuang, J. Mukherjee, C.-T. Chen, W. Green.   Neuroscience 2021, 11/13-16/2021, Chicago, IL.
  • Evaluation of gender differences in the uptake of PET probes 2-[18F]A85380 and [18F]nifene for nicotinic acetylcholine receptors in vivo.  Matthew D. Zammit, Chien-Min Kao, Hannah J. Zhang, Nathanial Holderman, Samuel Mitchell, Hsiu-Ming Tsai, Anitha P. Govind, Mohammed Bhuiyan, Richard Freifelder, Xiaoxi Zhuang, William N. Green, Jogeshwar Mukherjee, Chin-Tu Chen.  2021 World Molecular Imaging Congress, 10/6-9/21, Miami, FL
  • Development of A Novel 18F-PET Imaging Probe for Pancreatic Cancer.  Bhuiyan, M., Zeng, W., Kucharski, A., Freifelder, R., Chen, C-T., Chen, L. 2022 SNMMI Annual Meeting in Vancouver, British Columbia.
  • Current Cyclotron Facility Designs, regulatory Compliance, and Future Considerations.  Richard Freifelder, CE Session “Design and Implementation of Novel Cyclotron and Radiochemistry cGMP Facilities and Practices.” 2022 SNMMI Annual Meeting in Vancouver, British Columbia.
  • Targeting MUC1-C for Cancer Theranostics Using Humanized 47Sc-mAb 3D1. Bhuiyan, M., Zhang, H., Meier, J., Yamashita, N., Kankanamalage, P., Brossard, T., Tsai, H-M., Leoni, L., Kucharski, A., Freifelder, R., Nolen, J., Kao, C-M., Rotsch, D., Weichselbaum, R., Kufe, D., Chen, C-T. 2022 SNMMI Annual Meeting in Vancouver, British Columbia.
  • Addition of CEST-MR pH Imaging to a Multi-Modal Approach Using FMISO-PET, DCE-MRI, and EPR-pO2 to Improve Radiotherapy of Hypoxic Tumors.  L. Berens, I. Gertsenshteyn, E. Barth, X. Fan, B.B. Roman, H. Kim, B. Epel, L. Leoni, H.-M. Tsai, J. Lukens, R. Gambino,  D. Longo, S. Sundramoorthy, E. Markiewic, M, Bhuiyan, R. Freifelder, A. Kucharski, C.-M. Kao, H. Halpern, and C.-T. Chen.  Poster Presentation at the 2023 SNMMI Annal Meeting in Chicago, IL.

  • Analysis of Scandium-43 Production Using a Biomedical Cyclotron without a Dedicated Solid-Target System.  S. Penano, R. Freifelder, J. Meier, B. Broder, and C.-T. Chen. Oral presentation at the 2023 SNMMI Annal Meeting in Chicago, IL.

  • Novel Lipophilic-Cationic Molecular Probes for Enhanced Imaging of Mitochondria.  M. Bhuiyan, K. Ghosh, H. Zhang, J. Souris, B. Roman, Y. Pu, D. Applebaum, R. Freifelder and C.-T. Chen. Oral presentation at the 2023 SNMMI Annal Meeting in Chicago, IL.

  • Preclinical Study of a Novel Radiotheranostic Pair for Neuroendocrine Tumors: 43Sc/47Sc-DOTATATE.  A. J. Pusateri, H.J. Zhang, M. Bhuiyan, J.P. Meier, O. Lakiza, P. Kankanamalage, T. Brossard, H.-M. Tsai, L. Leoni, K. Ghosh, R Freifelder, C.-Y. Liao, Y. Pu, D. Appelbaum, R. Weichselbaum, J. Nolen, C.-M. Kao, D. Rotsch, X.M. Keutgen, C.-T. Chen. Poster presentation at the 2023 SNMMI Annal Meeting in Chicago, IL.

  • Development of 43Sc/47Sc-PSMA-617 as Theranostics for Prostate Cancer: Preliminary In-Vivo Molecular Imaging and Ex-Vivo Biodistribution in LNCaP Mouse Tumors.  J.P. Meier, M. Bhuiyan, H.J. Zhang, H.-M. Tsai, L. Leoni,  M. Mendez, P. Selman, P. Kankanamalage, T. Brossard, J. Nolen, R. Freifelder, W.M. Stadler, R. Weichselbaum, C.-M. Kao,  R.E. Moellering, K. Ghosh, A.J. Pusateri,  D.A. Rotsch, R. Szmulewitz, C.-T. Chen. Poster presentation at the 2023 SNMMI Annal Meeting in Chicago, IL.

Papers/Presentation (Submitted):