Projects/Grants

Projects (Internal/non-NIH Funding):

  • Proliferation and Nano-particle sensitizing agents. Chin-Tu Chen, Ph.D., PI. (18F-FLT) 
  • Total bone marrow irradiation in addition to fludarabine/melphalan conditioning. Hongtau Liu, M.D., PI. (18F-FLT, human use under a UC held IND).
  • Image-Guided Precision Radiotherapy of Hypoxic Tumors. Howard Halpern, M.D. & Chin-Tu Chen, Ph.D., co-PIs. (18F-Miso)
  • Pin 1 Marker for Pancreatic Cancer (with UIC).
  • Development of 18F – NaBF4 (with UIC).
  • Multiple Sclerosis Imaging Marker. Pedro Brugarolas, Ph.D., PI. (18F-3F4AP)
  • Development of 11C-PIB for clinical research use, Richard Freifelder, Ph.D., PI (11C-PIB)
  • Investigation of 48V labeled VO(acac)2 for Cancer Imaging, Chin-Tu Chen, Ph.D., PI (48VO(acac)2).
  • Nose to Brain Delivery of Insulin Growth Factor 1, Richard Kraig, Ph.D., PI.
  • Development of a novel glucocorticoid radiotracer as a predictive and pharmacodynamic biomarker for glucocorticoid receptor expressing (GR-positive) malignancies, Russell Szmulewitz, M.D PI.
  • Development of FEPPA, a translator protein radiotracer for glial activation, neuroinflammation, traumatic brain injury.  Joint University of Chicago, Northwestern University project, Richard Freifelder, Ph.D. (UC) and Steven Schwulst, M.D. (NW), PIs.
  • Direct labeling of compounds using11C-CO2, Mark Levin, Ph.D., PI.
  • Univ. Chicago Comprehensive Cancer Center UCHAP Team Science Research Award (Chen/Stadler).  Novel RadioTheranostics for High-Risk and Advanced Prostate Cancer.  04/16/2021 – 04/15/2023.
  • Department of Radiology Pilot Grant Seed Funds. Novel Lipophilic-Cationic Molecular Probes for Enhanced Imaging of Mitochondria, Mohammed Bhuiyan, Ph.D., PI.  10/01/2022 – 09/30/2023.

Grants (External Funding):

  • R01/S1 NS093908 (Carroll/Christoforidis). Development of Novel MR Imaging for Ischemia Stroke Evaluation.
  • R01 DA044760 (Green/Chen/Mukherjee). PET Imaging of α4β2 Nicotinic Receptor Upregulation and Smoking Cessation.  07/01/2017 – 04/30/2022.
  • R01 DA044760-02S1 (Green/Chen/Mukherjee).  Supplemental grant for adding an Alzheimer’s imaging agent to the R01 grant above.
  • DP2 GM128199 (Moellering). Targeting Transcription with Synthetic Biologicals. 09/30/2017 – 05/31/2022.
  • R01 CA098575 (Halpern). Radiation Biology of EPR Oxygen Images.  06/01/2003 – 03/31/2023.
  • R01 CA236385-2S1 (Chen/Halpern/Karczmar). Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, & MR Imaging.  04/15/2021 – 12/31/2024.
  • R01 GM130662 (Schwulst, Northwestern University).  The Role of Monocyte and Microglia Interaction in the Evolution of Traumatic Brain Injury-Induced Neurodegeneration.  09/01/2019- 07/31/2024.
  • R01 CA236385 (Chen/Halpern).  Improved Radiation Therapy of Hypoxic Tumor Regions by Integrating PET, EPR, and MR Imaging.  01/01/2020 – 12/31/2024
  • R01 EB29948 (Kao/Epel). A preclinical Integrated PET/EPR Imaging System.  06/01/2020 – 05/3/20.
  • P30 CA14599 (LeBeau).  UCCRC Cancer Center Support Grant: Program-Specific Pilot Grant – NanoTheranostics for Non-Invasive Treatment and Monitoring of Metastatic Colorectal Cancer. 06/01/2020 – 03/31/2022.
  • University of Chicago Office of Research and National Laboratories, UChicago (Chen/Rotsch). Novel Scandium-Based RadioTheranostics for Improved Diagnosis and Treatment of Prostate Cancer.
  • Young Investigator Award, Cancer Research Foundation (Levin). Next Generation PET Tracer Synthesis for Cancer Imaging. 09/01/2020 – 08/31/2021
  • R21 NS116638 (Schwulst, Northwestern University).  Blast-Induced TBI in the Ferret: Small Brains, Big Opportunities. 9/1/2020 – 8/31/2022.
  • Joint Task Force Initiative, Office of Research and National Laboratories, UChicago (Chen/Rotsch).  Argonne/UChicago Joint Radioisotope Initiatives.  10/01/2020 – 09/30/2021.

  • F31 CA254223 (Gertsernshteyn). Correcting 18F-Misonidasole PET with MRI and EPR to Improve Hypoxia-Guided Radiation Therapy. 04/01/2021 – 03/31/2024.