mirmiralab

The Mirmira Lab

Understanding the β cell in Diabetes

 

 

 

Diabetes is reaching epidemic proportions in the USA. A recent analysis revealed that the prevalence of pre-diabetes and diabetes in the US is in excess of 50%. Both major forms of diabetes, type 2 (T2D) and type 1 (T1D), are increasing in incidence in the USA. Similarly, it is becoming increasingly apparent that both forms of diabetes share cellular pathogeneses, where dysfunction and/or death of islet β cells is a common denominator. To that end, the Mirmira Lab is focused on understanding the specific role of the β cell during the pathogenesis of diabetes. Our laboratory has been focused on diabetes research for the past 20 years. Our lab has been host to high school students, undergraduates, graduate students, and postdoctoral scholars over these years, and more 50 people have trained in our lab and have gone on to careers as scientists, physicians, and educators. You can learn about our research and the members of our laboratory on this website. If you want to learn more about our lab and the research, contact us.

Mirmira Lab Alum Abhishek Kulkarni, PhD, Awarded 2022 HIRN Trainee Scholarship

He will present at the upcoming HIRN Annual Investigator Meeting.

Mirmira Lab Awarded Funding by the Human Islet Research Network (HIRN)

The project uses artificial intelligence to find new biomarkers for type 1 diabetes.

Postdoc Charanya Muralidharan, PhD, Awarded Grant from the Diabetes Research Connection

She will investigate the role of the integrated stress response in driving autoimmunity in type 1 diabetes.

Undergraduate Ebru Ermis Awarded Summer Fellowship by UChicago BSCD

Ebru will investigate the role of the receptor BLT2 in promoting macrophage migration during type 1 diabetes.

Undergraduate Emma Montgomery Received a Summer Research Fellowship from The College at UChicago

Emma is designing a humanized zebrafish model to test the function of insulin mutants.
Learn about our latest research

Research Areas

Lipoxygenase Pathway

12/15-lipoxygenase catalyzes the oxygenation of fatty acids to produce lipid pro-inflammatory mediators, the primary being 12-HETE. One of our initial studies showed that the deletion of 12/15-lipoxygenase in the pancreas is sufficient to protect against obesity-induced glucose intolerance, via a mechanism involving Nrf2-mediated activation of antioxidant genes (Tersey et al. MCB 2014).

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Polyamine Pathway

Pancreatic β cell proliferation is significantly reduced in adults. Interestingly, during the early phases of diabetes, the proliferative capacity of the β cells is increased, possibly for adapting to the increased insulin demand. Our lab has previously shown that the translation factor eIF5A acts as a sensor that catalyses the translation of mRNAs involved in cellular replication.

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Biomarkers

Type 1 diabetes (T1D) is a complex and heterogenous disease.  Insulin-producing β cells are the target of destruction by the immune system, and those who display autoantibodies against β cell antigens are at highest risk for developing the disease.  Development of autoantibodies is a relatively late event in the pathogenesis of the disease, and recent studies using immune-suppressive agents in these individuals delays the onset of diabetes, but does not prevent it

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Interested in Donating?

Your gift to the Mirmira Lab will support its groundbreaking research into beta cells, which produce insulin, and ways to protect them, strengthen them, and even re-grow them. With your help, we will advance in our shared goals of preventing diabetes, treating it more effectively, and ultimately curing it.

Our Publications

For a list of Mirmira Lab publications make sure to

Flat Stanley visits The Mirmira Lab

The Flat Stanley Project has become a global phenomenon thanks to Flat Stanley books by Jeff Brown.

The Mirmira Lab hosted a Flat Stanley from Ms. Melody Gayle’s second grade class at Waldron Elementary School in Shelby County, Indiana.

We hope that our Stanley was able to see that Science is F-U-N and we hope that his adventures with us inspires other young, curious minds to explore what a future career in STEM could look like!

 

 Our Lab is on Twitter!

We aim to be active in the broader scientific research community by sharing relevant information on our lab’s research via Twitter. See a few of our latest tweets, and give us a follow to stay in touch.

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