Rebay Lab Publications: present – 2006
Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina. Development. 2024 15;151(6):dev201757. doi: 10.1242/dev.201757.
Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila. Development. 2023 Apr 15;150(8):dev201467. doi: 10.1242/dev.201467.
Wu C., Boisclair Lachance JF, Ludwig MZ, Rebay I. A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition. PLoS Genetics. 2020; 16(11):e1009216. doi: 10.1371/journal.pgen.1009216.
Hope CM, Webber JL, Tokamov SA, Rebay I. Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife. 2018;7:131. doi:10.7554/eLife.37545.
Webber JL, Zhang J, Massey A, Sanchez-Luege N, Rebay I. Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development. May 2018:dev.165985. doi:10.1242/dev.165985.
Boisclair Lachance J-F, Webber JL, Hong L, Dinner AR, Rebay I. Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev. 2018;32(5-6):389-401. doi:10.1101/gad.307132.117.
Davis TL, Rebay I. Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network. Fly (Austin). 2018;12(1):62-70. doi:10.1080/19336934.2017.1402994.
Davis TL, Rebay I. Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina. Development. 2017;144(14):2640-2651. doi:10.1242/dev.147231.
Davis TL, Rebay I. Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks. Dev Biol. 2017;421(2):93-107. doi:10.1016/j.ydbio.2016.12.005.
Hope CM, Rebay I, Reinitz J. DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan. Biophys J. 2017;112(1):180-192. doi:10.1016/j.bpj.2016.11.901.
Davis TL, Hoi CSL, Rebay I. Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila. Lewin AS, ed. PLoS ONE. 2017;12(11):e0187546. doi:10.1371/journal.pone.0187546.
Hoi CSL, Xiong W, Rebay I. Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Genetics. 2016;203(3):1283-1295. doi:10.1534/genetics.115.185918.
Rebay I. Multiple Functions of the Eya Phosphotyrosine Phosphatase. Mol Cell Biol. 2015;36(5):668-677. doi:10.1128/MCB.00976-15.
Peláez N, Gavalda-Miralles A, Wang B, et al. Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation. Elife. 2015;4:723. doi:10.7554/eLife.08924.
Zhou Q, Zhang T, Jemc JC, et al. Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. Dev Biol. 2014;386(1):152-164. doi:10.1016/j.ydbio.2013.11.012.
Boisclair Lachance J-F, Peláez N, Cassidy JJ, Webber JL, Rebay I, Carthew RW. A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Dev Biol. 2014;385(2):263-278. doi:10.1016/j.ydbio.2013.11.002.
Webber JL, Rebay I. Long-range integration of repressive and patterning inputs. Cell Cycle. 2014;13(11):1653-1654. doi:10.4161/cc.29146.
Webber JL, Zhang J, Mitchell-Dick A, Rebay I. 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus. Genes Dev. 2013;27(21):2293-2298. doi:10.1101/gad.225789.113.
Qi J, Wang B, Pelaez N, et al. Drosophila Eye Nuclei Segmentation Based on Graph Cut and Convex Shape Prior. Int Conf Signal Process Proc. September 2013:670-674. doi:10.1109/ICIP.2013.6738138.
Webber JL, Rebay I. Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise? Fly (Austin). 2013;7(2):92-98. doi:10.4161/fly.24162.
Webber JL, Zhang J, Cote L, et al. The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics. 2013;193(2):633-649. doi:10.1534/genetics.112.146647.
Xiong W, Morillo SA, Rebay I. The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors. Development. 2013;140(1):176-184. doi:10.1242/dev.088799.
Qi J, Wang B, Pelaez N, et al. Drosophila eye nuclei segmentation based on graph cut and convex shape prior. IEEE International Conference on Signal Processing. 2013;978-1-4799-2341-0/13.
Morillo SA, Braid LR, Verheyen EM, Rebay I. Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Dev Biol. 2012;365(1):267-276. doi:10.1016/j.ydbio.2012.02.030.
Vivekanand P, Rebay I. The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2. PLoS ONE. 2012;7(5):e37151. doi:10.1371/journal.pone.0037151.
Xiong W, Rebay I. Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. Dev Dyn. 2011;240(7):1745-1755. doi:10.1002/dvdy.22674.
Graham TGW, Tabei SMA, Dinner AR, Rebay I. Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives. Development. 2010;137(14):2265-2278. doi:10.1242/dev.044826.
Zhang J, Graham TG, Vivekanand P, Cote L, Cetera M, Rebay I. Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan. Mol Cell Biol. 2010;30(5):1158-1170. doi:10.1128/MCB.01225-09.
Xiong W, Dabbouseh NM, Rebay I. Interactions with the abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell. 2009;16(2):271-279. doi:10.1016/j.devcel.2008.12.005.
Jemc J, Rebay I. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol. 2007;310(2):416-429.
Doroquez DB, Orr-Weaver TL, Rebay I. Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev. 2007;124(9-10):792-806.
Jemc J, Rebay I. The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem. 2007;76:513-538.
Jemc J, Rebay I. Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development. Genetics. 2006;173(1):279-286.
Doroquez DB, Rebay I. Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol. 2006;41(6):339-385.
Vivekanand P, Rebay I. Intersection of signal transduction pathways and development. Annu Rev Genet. 2006;40:139-157.
Jemc J, Rebay I. Targeting Drosophila eye development. Genome Biol. 2006;7(7):226.
Rebay Lab Publications 2005 -1998
Badenhorst P, Xiao H, Cherbas L, et al. The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev. 2005;19(21):2540-2545.
Schober M, Rebay I, Perrimon N. Function of the ETS transcription factor Yan in border cell migration. Development. 2005;132(15):3493-3504.
Mutsuddi M, Chaffee B, Cassidy J, Silver SJ, Tootle TL, Rebay I. Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent. Genetics. 2005;170(2):687-695.
Tchernitchko D, Chiminqgi M, Galacteros F, et al. Unexpected high frequency of P46L TNFRSF1A allele in sub-Saharan West African populations. Eur J Hum Genet. 2005;13(4):513-515. doi:10.1038/sj.ejhg.5201344.
Mutsuddi M, Rebay I. Molecular genetics of spinocerebellar ataxia type 8 (SCA8). RNA Biol. 2005;2(2):49-52.
Rebay I, Silver SJ, Tootle TL. New vision from Eyes absent: transcription factors as enzymes. Trends Genet. 2005;21(3):163-171.
Tootle TL, Rebay I. Post-translational modifications influence transcription factor activity: A view from the ETS superfamily. Bioessays. 2005;27(3):285-298.
Silver S, Rebay I. Signaling circuitries in development: Insights from the Retinal Determination Gene Network. Development. 2005;132:3-13.
- Silver SJ, Chen F, Doyon L, Zink AW, Rebay I. New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function. Genesis. 2004;39(4):263-272.
Mutsuddi M, Marshall CM, Benzow KA, Koob MD, Rebay I. The Spinocerebellar Ataxia 8 Noncoding RNA Causes Neurodegeneration and Associates with Staufen in Drosophila. Current Biology. 2004;14:302-308.
Voas MG, Rebay I. Signal integration during development: insights from the Drosophila eye. Dev Dyn. 2004;229(1):162-175. doi:10.1002/dvdy.10449.
Qiao F, Song H, Kim CA, et al. Derepression by Depolymerization: Structural Insights into the Regulation of Yan by Mae. Cell. 2004;118:163-173.
Vivekanand P, Tootle TL, Rebay I. MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Mech Dev. 2004;121(12):1469-1479.
Tootle TL, Lee PS, Rebay I. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Development. 2003;130:845-857.
Lin HV, Doroquez DB, Cho S, Chen F, Rebay I, Cadigan KM. Splits ends is a tissue/promoter specific regulator of Wingless signaling. Development. 2003;130:3125-3135.
Silver SJ, Davies EL, Doyon L, Rebay I. A functional dissection of Eyes absent reveals new modes of regulation within the retinal determination gene network. Molecular and Cellular Biology. 2003;23(17):5989-5999.
Tootle TL, Silver SJ, Davies EL, et al. The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature. 2003;426:299-302.
Voas MG, Rebay I. The Novel Plant Homeodomain Protein Rhinoceros Antagonizes Ras Signaling in the Drosophila Eye. Genetics. 2003;165:1993-2006.
Rebay I. Keeping the Receptor Tyrosine Kinase Signaling Pathway in Check: Lessons from Drosophila. Dev Biol. 2002;251(1):1-17.
Badenhorst P, Voas M, Rebay I, Wu C. Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 2002;16(24):3186–98.
Hsiao FC, Williams A, Davies EL, Rebay I. Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway. Dev Cell. 2001;1(1):51–61.
Rebay I, Fehon RG. Generating Antibodies against Drosophila Proteins. Drosophila Protocols. 2000;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York:389-411.
Chen F, Rebay I. split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells. Curr Biol. 2000;10(15):943-946.
Rebay I, Chen F, Hsiao F, et al. A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics. 2000;154(2):695-712.
Fox GL, Rebay I, Hynes RO. Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc Natl Acad Sci USA. 1999;96(26):14978-14983.
Rebay Publications 1997 – 1990
Rubin GM, Chang HC, Karim F, et al. Signal transduction downstream from Ras in Drosophila. Cold Spring Harb Symp Quant Biol. 1997;62:347-352.
Rebay I, Rubin GM. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell. 1995;81(6):857-866.
O’Neill EM, Rebay I, Tjian R, Rubin GM. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell. 1994;78(1):137-147.
Chang HC, Karim FD, O’Neill EM, et al. Ras signal transduction pathway in Drosophila eye development. Cold Spring Harb Symp Quant Biol. 1994;59:147-153.
Rebay I, Fortini ME, Artavanis-Tsakonas S. Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor inDrosophiladevelopment. C R Acad Sci III. 1993;316(9):1111-1123.
Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 1993;365(6446):p555-p557.
Rebay I, Fehon RG, Artavanis-Tsakonas S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell. 1993;74(2):319-329.
Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell. 1991;67(4):687-699.
Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development ofDrosophila: implications for notch function. J Cell Biol. 1991;113(3):657-669.
Artavanis-Tsakonas S, Delidakis C, Fehon R, et al. Notch and the molecular genetics of neuroblast segregation in Drosophila. Mol Reprod Dev. 1990;27(1):23-27. doi:10.1002/mrd.1080270107.
Fehon RG, Kooh PJ, Rebay I, et al. Molecular interactions between the protein products of the neurogenic lociNotchandDelta, two EGF-homologous genes in Drosophila. Cell. 1990;61(3):523-534.
Xu T, Rebay I, Fleming RJ, Scottgale TN, Artavanis-Tsakonas S. TheNotchlocus and the genetic circuitry involved in earlyDrosophilaneurogenesis. Genes Dev. 1990;4(3):464-475.