The Biomolecular NMR Core supports biochemical, biophysical, metabolomics research in the Biological Sciences Division at the University of Chicago. The facility houses a Bruker AVANCE IIIHD 600 and a Bruker AVANCE III 500 NMR spectrometer. These are equipped with high sensitivity inverse and broadband probes, single axis gradients, pulse shaping capabilities, variable temperature control(-50˚C to 150 ˚C), and automatic tuning and matching. The Bruker AVANCE IIIHD 600 is also equipped with a robotic sample changer (Bruker SamplExpress) allowing automated acquisition of up to 60 samples. Sample preparation can also be automated with our Gilson sample preparation robot.

In addition to our state-of-the-art NMR spectrometers, we also provide expert assistance and training in solution state NMR spectroscopy. We can help you chose the experiments you need to run, teach you how to set up and optimize them, and assist with data processing and interpretation. We have an array of advanced processing software and computation facilities to assist with spectra interpretation. Our facility can help you solve the structure of large biological molecules, perform drug binding studies, identify protein-protein interaction sites, monitor biochemically important motions, or identify metabolites in a complex biofluid. Please feel free to contact us regarding your research.