Screening Reagents
RNA Libraries
The CSC owns the Dharmacon siGENOME genome-wide human siRNA library. This library is subdivided into subsets of the human genome, human druggable, protein kinase, and GPCR which are available to be screened seperately.
Small Molecule Libraries
Life Chemicals Diversity Set (PS4)
It was purchased January 2019 and it is Life Chemicals’ newest, most novel (clean IP space) and best compounds available. There are 50,240 compounds and all compounds in the sets are drug-like and passed through over 50 medicinal chemistry filters on top of 5 standard filters covered by Lipinsky Rule of 5. [More info]
Life Chemicals Biologically Active Compound Library
It was purchased January 2019. This set contains 8,000 compounds which have been tested in functional, binding and other biological assays and have confirmed bioactivity in vitro and/or in vivo against various biological targets of pharmaceutical interest. The library has been designed on the base of ChEMBL database version 21. [More info]
Chem Bridge EXPRESS-Pick Collection
Contains 80,000 compounds from the MicroFormat library. The compounds were selected using novelty, diversity, drug-like property, and chemical structure analyses from both drug-like and lead-like compounds. [More info]
SelleckChem FDA-approved Drug Library
It was purchased in January 2019. This library contains 1953 small molecules. All drugs are from approved institutions such as FDA, EMA, HMA, CFDA, PMDA, or pharmacopoeia such as USP, BP, EP, JP, Ph.Int, etc. These small molecules are structurally diverse, medicinally active, and cell permeable, bioactivity and safety are confirmed by clinical trials. They are related to oncology, cardiology, anti-inflammatory, immunology, neuropsychiatry, analgesia etc. [More info]
Prestwick Chemical Library
This library contains 1,280 small molecules, 100% approved drugs (FDA, EMEA and other agencies) selected by medicinal chemists and pharmacists, thus it presents the greatest possible degree of drug-likeliness. The active compounds were selected for their high chemical and pharmacological diversity as well as for their known bioavailability and safety in humans. The Prestwick Chemical Library was designed to reduce the risk of “low quality” hits, reduce the cost of the initial screening, and accelerate lead discovery. [More info]
NCI Cancer Compounds (Approved Oncology Drug Set VII)
129 compounds that are FDA approved for cancer treatment. [More info]
NCI Diversity Set V
1593 compounds were derived from almost 140,000 compounds available for the distribution from the Developmental Therapeutic Program repository and selected based on the structural diversity. [More info]
NCI Mechanistic Set III
Made up of 813 compounds that were chosen to represent a broad range of growth inhibition pattern in the NCI60 cell line screen, based on the GI50 activity of the compound. [More info]
Analyticon NATx Synthetic Compound Library
Contains 5,000 synthetic compounds derived from natural products. It has made use of highly evolved natural products and parallel chemistry to complement and enhance other compound libraries. The design of this library uses Lipinski and Veber rules for simpler follow-up chemistry and hit to lead optimization. [More info]
Microsource Spectrum Library
Comprised of 2000 compounds that are 50% drugs approved by worldwide approval agencies, 30% pure natural products, and 20% other bioactive components which includes non-drug enzyme inhibitors, receptor blockers, membrane active compounds, and cellular toxins. [More info]
NCI Natural Products Set IV
Contains 419 compounds that were selected from the DTP Open Repository collection. [More info]