Ortho-C–H Methoxylation of Aryl Halides Enabled by a Polarity Reversed N–O Reagent
Modular synthesis of 1,2-azaborines via ring-opening BN-isostere benzannulation
Rhodium-Catalyzed Diastereo- and Enantioselective Divergent Annulations between Cyclobutanones and 1,5-Enynes: Repaid Construction of Complex C(sp3)-Rich Scaffolds
Iridium-Catalyzed Intramolecular β-C–H Alkenylation of Ketones with Alkynes via a Hydride-Transfer Approach
Our research interests is to harness the power of transition-metal catalysts to address the challenges in the arena of chemoselectivity and multi-step synthesis. Our research philosophy is guided by three questions:
1) What would be the most efficient way to introduce functional groups into (small or large) organic molecules?
2) What would be the most efficient method to synthesize various molecular skeletons (bridged or fused rings) with high complexity?
3) What would be the most efficient strategy to access mutiple structurally complicated and biologically important natural products and their analogues in a rapid fashion?
Methyl ketones as alkyl halide surrogates: a deacylative halogenation approach for strategic functional group conversions developed by our group was highlighted on "Some Items of Interest to Process R&D Chemist and Engineers". For details, see: link