The Fehon Lab

Cellular organization and function of the Hippo Pathway in tissue growth control


Tokamov, S.A., Buiter, S., Ullyot, A., Scepanovic, G., Williams, A.M., Fernandez-Gonzalez, R. Horne-Badovinac, S. Fehon, R.G. (2024). Cortical tension regulates Hippo signaling via Par-1-mediated Kibra degradation. Mol Biol Cell, 35(1):ar2.

Tokamov, S.A., Nouri, N., Rich, A., Buiter, S., Glotzer, M. Fehon, R.G. (2023) Apical polarity and actomyosin dynamics control Kibra subcellular localization and function in Drosophila Hippo signaling. Dev Cell 58(19):1864-1879. doi:10.1016/j.devcel.2023.08.029.

Tokamov, S.A., Su, T., Ullyot, A., Fehon, R.G. (2021) Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription. eLife. 10. PMC7895526

Rich, A., Fehon, R.G., Glotzer, M. (2020) Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos. eLife. 9. PMC7717907

Yee, W.B., Delaney, P.M., Vanderzalm, P.J., Ramachandran, S., Fehon, R.G. (2019) The CAF-1 Complex Couples Hippo Pathway Target Gene Expression and DNA Replication. Mol Biol Cell. 30, 2929-2942. PMC6822585

Xu, J., Su T., Tokamov, S.A., and Fehon, R.G. (2019). Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs. Methods Mol Biol. 1893, 53-59.

Xu, J., Vanderzalm, P.J., Ludwig, M., Su, T., Tokamov, S.A., and Fehon, R.G. (2018). Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Dev. Cell. 46, 271-284. PMC6086586

Matakatsu H., Blair S.S., and Fehon R.G. (2017). Size does matter! Cell Cycle 16, 1-2.

Su, T., Ludwig, M. Xu, J., and Fehon, R.G. (2017). Kibra and Merlin activate the Hippo pathway spatially distinct from and independent of Expanded. Dev. Cell. 40, 478-490.PMC5414729

Matakatsu, H., Blair, S. S., and Fehon, R. G. (2017). The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat. JCB216, 265-277. PMC5223609

Zhang, Y., Wang, X., Matakatsu, H., Fehon, R. and Blair, S. S. (2016). The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs. eLife5,e16624.PMC5047748

Sherrard KM, Fehon RG. (2015). The transmembrane protein Crumbs displays complex dynamics during follicular morphogenesis and is regulated competitively by Moesin and aPKC. Development, 142, 1869-78. PMC4440922

Gavilan, H.S., Kulikauskas, R.M., Gutmann, D.H., and Fehon, R.G. (2014). In vivo functional analysis of the human NF2tumor suppressor gene in Drosophila. PLoS ONE 9,e90853. PMC3942481

Hall, S., Bone, C., Oshima, K., Zhang, L., McGraw, M., Lucas, B., Fehon, R.G., and Ward, R.E. (2014). Macroglobulin complement-related encodes a protein required for septate junction organization and paracellular barrier function in Drosophila. Development, 141, 889-898. PMC3912832

Neisch, A.L., Formstecher, E., and Fehon, R.G. (2013).Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Mol. Biol. Cell 24,1420–1433. PMC3639053 (A Highlights from MBoC selection).

Boggiano, J.C., and Fehon, R.G. (2012). Growth control by committee: intercellular junctions, cell polarity, and the cytoskeleton regulate hippo signaling. Dev Cell 22, 695–702. PMC3376383

Fehon, R. (2012). An MBoC Favorite: Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site. Mol Biol Cell23,1607.

Boggiano, J.C, Vanderzalm, P.J. and Fehon, R.G. (2011). Tao-1 Phosphorylates Hippo/MST kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway. Dev. Cell. 21, 888-895. PMC3217187 (‘Featured Article’)

Oshima, K. and Fehon, R.G. (2011) Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs Large. J. Cell Sci. 124, 2861-71. PMC3148133

Neisch, A.L. and Fehon, R.G. (2011). Ezrin, Radixin and Moesin: Key regulators of membrane-cortex interactions and signaling. Curr. Opin. Cell Biol. 23, 377-82. PMC3148288

Nilton, A., Oshima, K., Zare, F., Byri, S., Nannmark, U., Nyberg, K.G., Fehon, R.G., and Uv, A.E. (2010) Crooked, Coiled and Crimpled are three Ly6-like proteins required for proper localization of septate junction components. Development, 137, 2427-2437. PMC2889608.

Benseñor LB, Barlan K, Rice SE, Fehon RG, Gelfand VI. (2010). Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. Proc Natl Acad Sci U S A. 107, 7311-6. PMC2867680.

Neisch, A.L., Speck, O., Stronach, B., and Fehon, R.G. (2010). Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J. Cell Biol. 189, 311-23. PMC2856900

Hughes, SC, Formstecher, E., and Fehon RG. (2010). Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate moesin activity. J. Cell Sci. 123, 1099-107. PMC2844318.

Fehon, RG, McClatchey, AI, and Bretscher, A. (2010). Organizing the Cell Cortex: The role of ERM proteins. Nat. Rev. Mol. Cell Biol. 11, 276-287. PMC2871950.

McClatchey, A.I. and Fehon, R.G. (2009). Merlin and the ERM proteins – regulators of receptor distribution and signaling at the cell cortex. Trends Cell Biol. 19, 198-206. PMC2796113.

Neisch, A. and Fehon, R.G. (2008). FERMing up the plasma membrane. Dev. Cell 14, 154-156.

Hughes SC, Fehon RG. (2007). Understanding ERM proteins–the awesome power of genetics finally brought to bear. Curr. Opin. Cell Biol. 19, 51-6. PMC2064571.

Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, and Tesmer J. (2007). Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. J. Mol. Biol. 365, 1446-59. PMC1796844.

Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD. (2006). Delineation of a Fat tumor suppressor pathway. Nat Genet. 38, 1142-50

Hughes, S. and Fehon, R.G. (2007). Phosphorylation and activity of the tumor-suppressor Merlin and the ERM protein Moesin are co-ordinately regulated by the SLIK kinase. J. Cell Biol. 175, 305-313. PMC2064571.

Fehon, R.G. (2006). Polarity bites. Nature 442, 519-520.

Maitra, S., Kulikauskas, R., Gavilan, H., and Fehon, R.G. (2006). The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr. Biol. 16, 702-709.

Formstecher, E., et al. (2005). Protein interaction mapping: A Drosophila case study. Genome Res. 15, 376-384.

Genova, J. and Fehon, R.G. (2003). Neuroglian, Gliotactin, and the Na+/K+ATPase are essential for septate junction function in Drosophila. J. Cell Biol.161, 979-989.

Speck, O., Hughes, S.C., Noren, N.K., Kulikauskas, R.M., and Fehon, R.G. (2003). Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature 421, 83-87.

Bretscher, A., Edwards, K, and Fehon, R.G. (2002). ERM proteins and Merlin: Integrators at the cell cortex. Nature Rev. Mol. Cell Biol., 3, 586-599.

Tepass, U., Tanentzapf, G., Ward, R., and Fehon, R. (2001). Epithelial cell polarity and cell junctions in Drosophila. Ann. Rev. Genet., 35, 747-784.

Ward, R. E. I., Schweizer, L., Lamb, R.S., and Fehon, R.G. (2001). The FERM domain of DrosophilaCoracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation. Genetics 159, 219-228.

LaJeunesse, D. R., McCartney, B. M., and Fehon, R.G. (2001). A systematic screen for dominant second-site modifiers of Merlin/NF2phenotypes reveals an interaction with blistered/DSRFand scribbler. Genetics 158, 667-679.

Lim, D. J., Rubenstein, A. E., Evans, D. G., Jacks, T., Seizinger, B. G., Baser, M. E., Beebe, D., Brackmann, D. E., Chiocca, E. A., Fehon, R. G., Giovannini, M., Glazer, R., Gusella, J. F., Gutmann, D. H., Korf, B., Lieberman, F., Martuza, R., McClatchey, A. I., Parry, D. M., Pulst, S. M., Ramesh, V., Ramsey, W. J., Ratner, N., Rutkowski, J. L., Ruttledge, M., Weinstein, D. E. (2000). “Advances in Neurofibromatosis 2 (NF2): A Workshop Report.” J. Neurogenet. 14, 63-106.

Rebay, I. and Fehon, R.G. (2000) Antibodies against Drosophila proteins. In “Drosophila Protocols”. W. Sullivan, M. Ashburner, and S. Hawley, eds. 728 pp.

Genova, J., Jong, S., Camp, J.T., and Fehon, R.G. (2000). Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophiladevelopment. Dev. Biol. 221, 181-194.

McCartney, B.M, Kulikauskas, R., LaJeunesse, D.L., and Fehon, R.G. (2000). The Neurofibromatosis-2homologue, Merlin, and the Drosophila tumor suppressor expandedfunction together to regulate cell proliferation and differentiation. Development 127, 1315-1324.

Lamb, R.S., Ward, R.E., Schweizer, L., and Fehon, R.G. (1998) Drosophilacoracle, a member of the Protein 4.1 superfamily, has essential structural functions in the septate junction and developmental functions in embryonic and adult epithelial cells. Mol. Biol. Cell, 9, 3505-3519.

Chishti, A.H. et al. (1998) The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. TIBS 23, 281-282.

LaJeunesse, D., McCartney, B.M., and Fehon, R.G. (1998) Structural analysis of DrosophilaMerlin reveals functional domains important for growth control and subcellular localization. J. Cell Biol. 141, 1589-1599.

Ward, R.E., Lamb, R.S., and Fehon, R.G. (1998) A conserved functional domain of DrosophilaCoracle is required for localization at the septate junction and has membrane organizing activity. J. Cell Biol., 140, 1463-1473.

Fehon, R.G., Oren, T., LaJeunesse, D.R., Melby, T., and McCartney, B.M. (1997) Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis-2and yeast CDC42genes using a simple and efficient reverse-genetic method. Genetics 146, 245-252.

McCartney, B.M. and Fehon, R.G. (1996). Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the NF2 tumor-suppressor merlin. J. Cell Biol., 133, 843-852.

Fehon, R.G., Dawson, I., and Artavanis-Tsakonas, S. (1994). A Drosophilahomologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development, 120, 545-557.