Autism spectrum disorders (ASDs) are a genetically and phenotypically diverse set of neuropsychiatric disorders that are characterized by social deficits, repetitive behaviors, and challenges with communication. With the recent explosion of next generation sequencing, outstanding advances have been made in understanding the types of genes that can lead to ASDs.

Our work is focused on a novel expression system we identified in several calcium channel genes that are linked to autism as well as numerous other neuropsychiatric disorders. This novel expression system gives rise to previously uncharacterized proteins that we believe can contribute to the diverse phenotypes observed in ASDs. Specifically, we are focused on understanding how these proteins are made, how they affect widespread gene expression in neurons, and how their localization within neurons is regulated. Together, these insights could provide a new pathway that can help better explain how single mutations in critical risk genes can lead to widespread genetic dysregulation as seen in many ASDs.

Here’s a list of the innovative projects and researchers that were part of our 2020 Chicago Symposium on Translational Neuroscience.

>Translational Neuroscience of Autism<

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