Welcome to the Advanced Electron Microscopy Facility
The Advanced Electron Microscopy Facility occupies over 2000 ft2 in the Gordon Center for Integrative Sciences (GCIS) and an additional 3000 ft2 of new space in the Franklin McLean Institute. The mission of the facility is to develop techniques for preserving cellular structure with the highest degree of reliability. These techniques involve different methods for rapidly freezing our samples in order to halt structural and biochemical activity in a very short time-frame, thus preserving structure in the “live” state. Once the sample is preserved in the “live” state, it is then possible to study the ultrastructure of these samples using not only basic Electron Microscopy imaging techniques, but also state-of the-art techniques such as: 1) 3-D electron tomography (cryo and plastic), 2) Single Particle Analysis (SPA), and 3) CLEM.
For Publications
We track publications in which the Advanced Electron Microscopy Core helped in the collection of data or images. Help us by acknowledging us in your work and sending us your publication to be featured on our site.
Acknowledging the facility and listing the core equipment used helps demonstrate how our core contributes to the university community and track the impact of each piece of equipment on research infrastructure.
The Core can be cited as follows:
The Advanced Electron Microscopy Core may be identified in publications as The University of Chicago Advanced Electron Microscopy Core Facility (RRID:SCR_019198).
Our Boilerplate Text is also available.
Equipment Status
The Advanced EM works hard to ensure all our equipment is up and running for user’s needs.
In the event that the equipment you need is unavailable or has ongoing issues, we will update the equipment status page to keep you updated.
Krios Loading Submission Form
If you have an upcoming Krios screening, please remember
to fill out the Krios Loading Submission Form and email it to:
tlavoie@uchicago.edu fullerj@uchicago.edu and joe.austin.em@gmail.com
Submit a sample for the Krios!
Internal users: Fill out the Internal Submission Form and email it to:
tlavoie@uchicago.edu and fullerj@uchicago.edu.
Updated: March 1, 2021
External users: Contact core staff for guidelines.
Interview with Bobby Kasthuri
Bobby Kasthuri’s group uses the core facility to image using our volumescope.
Understanding the effects of drugs on the brain: A look at the damage and potential for treatment