by hcrees | Sep 14, 2021 | Publication
The programmed −1 ribosomal frameshifting element (PFSE) of SARS-CoV-2 is a well-conserved structured RNA found in all coronaviruses’ genomes. By adopting a pseudoknot structure in the presence of the ribosome, the PFSE promotes a ribosomal frameshifting event near...
by hcrees | Aug 9, 2019 | News, Publication
https://www.nature.com/articles/s41467-019-11585-z Picornaviral IRES elements are essential for initiating the cap-independent viral translation. However, three-dimensional structures of these elements remain elusive. Here, we report a 2.84-Å resolution crystal...
by hcrees | Jul 25, 2019 | News
Our group is broadly interested in the chemistry and biochemistry of nucleic acids with particular emphasis on RNA and RNA catalysis. The laboratory integrates areas of organic chemistry, physical chemistry, enzymology and molecular biology to gain a fundamental...
