In William James’ radical empiricism, he employs “experience” as a relational notion as an attempt to overcome the subject-object dualism, which in many ways differ from the mainstream use of the term. This cause difficulty in understanding James’ radical empiricism. On the other hand, a distinctive characteristic of early Chinese thinking is its understanding of existence as based on interaction, and understanding determination of things as emergent in such interaction. This relational thinking structure may help us better understand James’ notion of the “context of experience.” Through this comparison we might be able to better understand the continuity and complexity of the content of the human experience, and to also celebrate the capacity of human beings to optimize the creative possibilities of this experience to live significant lives.