Core Biopsy (General / NOS)

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Unless a core biopsy has other specific instructions per organ system, please use the following as general guidelines:


  • Submit ONE intact core per cassette, between sponges. Use multiple cassettes if needed.
  • If core is calcified and molecular testing is anticipated, isolate these fragments in a separate cassette(s), fix, and then decalcify in EDTA. Ask PAs for assistance. Be sure to state “after decalcification” in your cassette summary and add a Decal stain in CoPath.
  • Histology Protocols:
    • If biopsy is for molecular testing: make sure protocol is for 1 H&E Level ONLY.
    • In other cases, for ONE of the cassettes: make sure histology protocol is for a 10 Level FNB biopsy (i.e. Levels 1 and 10 should be H&E-stained slides, Levels 2 through 9 should be unstained slides). Ask the front desk to change the protocol if you need help. Ask an attending if you are unsure if FNB protocol is needed.
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