By The University of Chicago Department of Pathology
Core Biopsy (General / NOS)
Auto Text: “Insert Core Biopsy”
Unless a core biopsy has other specific instructions per organ system, please use the following as general guidelines:
Submit ONE intact core per cassette, between sponges. Use multiple cassettes if needed.
If core is calcified and molecular testing is anticipated, isolate these fragments in a separate cassette(s), fix, and then decalcify in EDTA. Ask PAs for assistance. Be sure to state “after decalcification” in your cassette summary and add a Decal stain in CoPath.
If biopsy is for molecular testing: make sure protocol is for 1 H&E Level ONLY.
In other cases, for ONE of the cassettes: make sure histology protocol is for a 10 Level FNB biopsy (i.e. Levels 1 and 10 should be H&E-stained slides, Levels 2 through 9 should be unstained slides). Ask the front desk to change the protocol if you need help. Ask an attending if you are unsure if FNB protocol is needed.